Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown
Published: June 28, 2024
Language: Английский
Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)
Published: Feb. 17, 2025
Vitexin (VI) is a naturally occurring flavonoid derived from the leaves and seeds of Vitex, recognized for its strong antioxidant properties. This study aims to explore effects on renal ischemia-reperfusion injury (IRI) investigate underlying mechanisms. We utilized hypoxia-reoxygenation (H/R) models with HK-2 cell lines (I/R) in mice, applying vitexin preconditioning assess influence IRI. Our findings reveal that mitigated oxidative stress, decreased apoptosis, reduced expression damage indicators such as kidney molecule-1 (KIM-1) neutrophil gelatinase-associated lipocalin (NGAL), along an overall improvement function. To further mechanism, we used network pharmacology molecular docking techniques predict potential targets Results Western blotting immunofluorescence assays indicate may promote mitophagy by suppressing phosphorylation pivotal p38 protein p38/MAPK signaling pathway, offering protection against The could potentially be therapeutic agent alleviate
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 151, P. 114341 - 114341
Published: March 1, 2025
Language: Английский
Citations
0
The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 106730 - 106730
Published: March 1, 2025
Language: Английский
Citations
0
Cell Biochemistry and Function, Journal Year: 2025, Volume and Issue: 43(4)
Published: April 1, 2025
ABSTRACT Diabetic kidney disease (DKD) is a major diabetic microvascular complication that still lacks effective therapeutic drugs. Ferroptosis recently identified form of programmed cell death triggered by iron overload. It characterized unrestricted lipid peroxidation and subsequent membrane damage found in various diseases. Accumulating evidence has highlighted the crucial roles overload ferroptosis DKD. Here, we review metabolism biology ferroptosis. The role aberrant inducing diverse renal intrinsic death, oxidative stress, fibrosis DKD summarized, elaborate on critical regulatory factors related to Finally, focused significance treatment highlight recent data regarding novel activities some drugs as inhibitors DKD, aiming provide new research targets strategies
Language: Английский
Citations
0
Journal of Asian Natural Products Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 29
Published: April 25, 2025
Flavonoids, abundant in the human diet, have been extensively studied for their therapeutic bioactivities. Recent research has made significantly advances our understanding of biological activities flavonoids, demonstrating effects various chronic diseases. However, generally low bioavailability flavonoids limits effectiveness. Therefore, it is essential to explore pharmacokinetics paying particular attention roles transporters and metabolizing enzymes. This paper reviews recent studies on bioactivity highlighting importance metabolic enzymes pharmacokinetics.
Language: Английский
Citations
0
Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)
Published: May 6, 2025
Ferroptosis is a regulated, iron-dependent form of cell death driven by lipid peroxidation and distinct from apoptosis, necroptosis, pyroptosis. Recent studies implicate ferroptosis as central contributor to the pathogenesis renal fibrosis, hallmark chronic kidney disease associated with high morbidity progression end-stage failure. This review synthesizes current evidence linking ferroptotic signaling fibrotic remodeling in kidney, focusing on iron metabolism dysregulation, glutathione peroxidase 4 (GPX4) inactivation, peroxide accumulation, ferroptosis-regulatory pathways such FSP1-CoQ10-NAD(P)H GCH1-BH4. We detail how tubular epithelial cells modulates pro-fibrotic cytokine release, macrophage recruitment, TGF-β1-driven extracellular matrix deposition. Moreover, we explore therapeutic vulnerability highlighting promising agents including chelators, GPX4 activators, anti-lipid peroxidants, exosome-based gene delivery systems. By consolidating emerging preclinical data, this provides comprehensive mechanistic framework identifies translational opportunities for targeting disease.
Language: Английский
Citations
0
Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119981 - 119981
Published: May 1, 2025
Language: Английский
Citations
0
Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155499 - 155499
Published: March 3, 2024
Language: Английский
Citations
3
International Immunopharmacology, Journal Year: 2023, Volume and Issue: 124, P. 110906 - 110906
Published: Sept. 9, 2023
Treatment of steroid-induced osteonecrosis the femoral head (SIONFH) is challenging. Due to limited understanding its molecular mechanisms, investigating potential mechanisms ferroptosis will shed light on SIONFH and provide directions for treating this disease.The GSE123568 dataset was utilized apply various bioinformatics methodologies identify ferroptosis-related hub genes (FRHGs). Subsequently, importance these reliability results were confirmed using protein data-independent acquisition (DIA) cell experiments. Finally, we assessed correlation between FRHG expression immune infiltration.Thirty-one identified validated by constructing a protein-protein interaction network subsequent screening experimentally determined interactions. These 31 enriched in immunity, AMPK signaling pathway, Toll-like receptor pathway. Next, diagnostic marker comprising two genes, NCF2 SLC2A1. The differential healthy necrotic regions DIA analysis. Cell experiments verified link FRHGs preliminarily explored mechanism antioxidant vitexin promoting osteogenic differentiation cells. efficiency markers receiver operating characteristic curve (ROC) curves, yielding an area under 1.0. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) indicated enrichment superoxide anion HIF-1 pathways. A significant observed populations.NCF2 SLC2A1 are promising biomarkers SIONFH. Concurrently, embarked preliminary investigation elucidate underlying promotion vitexin. Moreover, associated with distinct populations.
Language: Английский
Citations
7
Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12
Published: March 6, 2024
Objective Exploring the mechanism of ferroptosis as a potential avenue for investigating pathogenesis and therapeutic outlook diabetes mellitus its complications has emerged focal point within recent years. Herein, we employ bibliometric approach to delineate current landscape research in context mellitus. Our objective is furnish insights scholarly references conducive advancement comprehensive investigations innovations related domains. Methods We included studies on diabetes, obtained from Web Science Core Collection. All publications were transported plaintext full-record format analyzed by CiteSpace 6.2.R4 analysis. Results Four hundred forty-eight records that met criteria included. The released during initial 3 years relatively small, while there was sudden surge published 2022 2023. Representing 41 countries 173 institutions, China Wuhan University led diabetes. author with highest number papers Zhongming Wu, Dixon SJ most frequently cited author. journal co-citations Cell . common keywords include oxidative stress, cell death, lipid peroxidation, metabolism. Extracted predominantly focus NLRP3 inflammatory, diabetic kidney disease, mitochondria, iron overload, cardiomyopathy. Conclusion escalating recognition target deciphering intricate mechanisms underlying underscored noteworthy relevant publications. This catapulted into spotlight burgeoning vibrant field.
Language: Английский
Citations
2