Ergothioneine suppresses hepatic stellate cell activation via promoting Foxa3-dependent potentiation of the Hint1/Smad7 cascade and improves CCl4-induced liver fibrosis in mice DOI
Guangwen Shu, Lei Xiao,

Guangqiong Li

и другие.

Food & Function, Год журнала: 2023, Номер 14(23), С. 10591 - 10604

Опубликована: Янв. 1, 2023

EGT is a bioactive compound derived from certain edible mushrooms. Here, we showed that inhibits HSC activation and improves CCl 4 -induced mouse liver fibrosis by promoting nuclear translocation of Foxa3 in HSCs to potentiate the Hint1/Smad7 axis.

Язык: Английский

Water extract of earthworms mitigates kidney injury triggered by oxidative stress via activating intrarenal Sirt1/Nrf2 cascade and ameliorating mitochondrial damage DOI
Guangwen Shu,

Chuo Wang,

Anning Song

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер 335, С. 118648 - 118648

Опубликована: Июль 31, 2024

Язык: Английский

Процитировано

9

Natural products targeting AMPK signaling pathway therapy, diabetes mellitus and its complications DOI Creative Commons
Min Li,

Lu Ding,

L. Cao

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 3, 2025

Diabetes mellitus (DM) ranks among the most prevalent chronic metabolic diseases, characterized primarily by a persistent elevation in blood glucose levels. This condition typically stems from either insufficient insulin secretion or functional defect itself. Clinically, diabetes is classified into type 1 (T1DM) and 2 (T2DM), with T2DM comprising nearly 90% of all diagnosed cases. Notably, global incidence has surged dramatically over recent decades. The adenylate-activated protein kinase (AMPK) signaling pathway crucial regulating cellular energy metabolism, marking it as significant therapeutic target for related complications. Natural products, their diverse origins, multifaceted bioactivities, relative safety, hold considerable promise modulating AMPK pathway. review article explores advances research on natural products that pathway, aiming to inform development innovative antidiabetic therapies.

Язык: Английский

Процитировано

1

Ethanol Extract of Rosa rugosa Ameliorates Acetaminophen-Induced Liver Injury via Upregulating Sirt1 and Subsequent Potentiation of LKB1/AMPK/Nrf2 Cascade in Hepatocytes DOI Creative Commons

Yecheng Lei,

Lei Xiao, Anqi Zhu

и другие.

Molecules, Год журнала: 2023, Номер 28(21), С. 7307 - 7307

Опубликована: Окт. 28, 2023

Acetaminophen (APAP)-induced liver injury is a common hepatic disease resulting from drug abuse. Few targeted treatments are available clinically nowadays. The flower bud of Rosa rugosa has wide range biological activities. However, it unclear whether alleviates caused by APAP. Here, we prepared an ethanol extract (ERS) and analyzed its chemical profile. Furthermore, revealed that ERS significantly ameliorated APAP-induced apoptosis ferroptosis in AML-12 hepatocytes dampened APAP-mediated cytotoxicity. In cells, elevated Sirt1 expression, boosted the LKB1/AMPK/Nrf2 axis, thereby crippled intracellular oxidative stress. Both EX527 NAM, which chemically unrelated inhibitors Sirt1, blocked ERS-induced activation signaling. protection against APAP-triggered toxicity cells was subsequently abolished. As expression LKB1 knocked down, still upregulated but failed to activate AMPK/Nrf2 cascade or suppress cytotoxicity provoked Results vivo experiments showed attenuated APAP-caused hepatocyte improved inflammation. Consistently, increased phosphorylations AMPK, promoted Nrf2 nuclear translocation livers APAP-intoxicated mice. Hepatic transcriptions HO-1 GCLC, downstream antioxidant genes Nrf2, were also response ERS. Our results collectively indicated effectively attenuates activating cascade. Upregulated plays crucial role ERS-mediated LKB1.

Язык: Английский

Процитировано

8

Water extract of earthworms mitigates mouse liver fibrosis by potentiating hepatic LKB1/Nrf2 axis to inhibit HSC activation and hepatocyte death DOI
Tiantian Zhang,

Chuo Wang,

Anning Song

и другие.

Journal of Ethnopharmacology, Год журнала: 2023, Номер 321, С. 117495 - 117495

Опубликована: Ноя. 26, 2023

Язык: Английский

Процитировано

6

Comparative studies on the antioxidant, anticancer and anti-inflammatory activities of green tea, orthodox black tea and CTC black tea DOI

Arpan Singha Deo,

P. J. Asheela Devi,

Kunnathully Sudhan Sijisha

и другие.

Journal of Food Science and Technology, Год журнала: 2023, Номер 61(7), С. 1315 - 1325

Опубликована: Дек. 19, 2023

Язык: Английский

Процитировано

6

Discovery of the Natural Bibenzyl Compound Erianin in Dendrobium Inhibiting the Growth and EMT of Gastric Cancer through Downregulating the LKB1-SIK2/3-PARD3 Pathway DOI Open Access
Xin Wei,

Qunshan Liu,

Liu Liu

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(14), С. 7973 - 7973

Опубликована: Июль 21, 2024

Erianin, a bibenzyl compound found in dendrobium extract, has demonstrated broad anticancer activity. However, its mechanism of action gastric cancer (GC) remains poorly understood.

Язык: Английский

Процитировано

1

Signaling pathways that activate hepatic stellate cells during liver fibrosis DOI Creative Commons

Youtian Zhang,

Long Ren,

Yinting Tian

и другие.

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Сен. 18, 2024

Liver fibrosis is a complex process driven by various factors and key feature of chronic liver diseases. Its essence tissue remodeling caused excessive accumulation collagen other extracellular matrix. Activation hepatic stellate cells (HSCs), which are responsible for production, plays crucial role in promoting the progression fibrosis. Abnormal expression signaling pathways, such as TGF-β/Smads pathway, contributes to HSCs activation. Recent studies have shed light on these providing valuable insights into development Here, we will review six pathways that been studied more recent years.

Язык: Английский

Процитировано

1

Ergothioneine suppresses hepatic stellate cell activation via promoting Foxa3-dependent potentiation of the Hint1/Smad7 cascade and improves CCl4-induced liver fibrosis in mice DOI
Guangwen Shu, Lei Xiao,

Guangqiong Li

и другие.

Food & Function, Год журнала: 2023, Номер 14(23), С. 10591 - 10604

Опубликована: Янв. 1, 2023

EGT is a bioactive compound derived from certain edible mushrooms. Here, we showed that inhibits HSC activation and improves CCl 4 -induced mouse liver fibrosis by promoting nuclear translocation of Foxa3 in HSCs to potentiate the Hint1/Smad7 axis.

Язык: Английский

Процитировано

3