Natural products targeting AMPK signaling pathway therapy, diabetes mellitus and its complications

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 3, 2025

Diabetes mellitus (DM) ranks among the most prevalent chronic metabolic diseases, characterized primarily by a persistent elevation in blood glucose levels. This condition typically stems from either insufficient insulin secretion or functional defect itself. Clinically, diabetes is classified into type 1 (T1DM) and 2 (T2DM), with T2DM comprising nearly 90% of all diagnosed cases. Notably, global incidence has surged dramatically over recent decades. The adenylate-activated protein kinase (AMPK) signaling pathway crucial regulating cellular energy metabolism, marking it as significant therapeutic target for related complications. Natural products, their diverse origins, multifaceted bioactivities, relative safety, hold considerable promise modulating AMPK pathway. review article explores advances research on natural products that pathway, aiming to inform development innovative antidiabetic therapies.

Language: Английский

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Water extract of earthworms mitigates kidney injury triggered by oxidative stress via activating intrarenal Sirt1/Nrf2 cascade and ameliorating mitochondrial damage

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 335, P. 118648 - 118648

Published: July 31, 2024

Language: Английский

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Ethanol Extract of Rosa rugosa Ameliorates Acetaminophen-Induced Liver Injury via Upregulating Sirt1 and Subsequent Potentiation of LKB1/AMPK/Nrf2 Cascade in Hepatocytes

Molecules, Journal Year: 2023, Volume and Issue: 28(21), P. 7307 - 7307

Published: Oct. 28, 2023

Acetaminophen (APAP)-induced liver injury is a common hepatic disease resulting from drug abuse. Few targeted treatments are available clinically nowadays. The flower bud of Rosa rugosa has wide range biological activities. However, it unclear whether alleviates caused by APAP. Here, we prepared an ethanol extract (ERS) and analyzed its chemical profile. Furthermore, revealed that ERS significantly ameliorated APAP-induced apoptosis ferroptosis in AML-12 hepatocytes dampened APAP-mediated cytotoxicity. In cells, elevated Sirt1 expression, boosted the LKB1/AMPK/Nrf2 axis, thereby crippled intracellular oxidative stress. Both EX527 NAM, which chemically unrelated inhibitors Sirt1, blocked ERS-induced activation signaling. protection against APAP-triggered toxicity cells was subsequently abolished. As expression LKB1 knocked down, still upregulated but failed to activate AMPK/Nrf2 cascade or suppress cytotoxicity provoked Results vivo experiments showed attenuated APAP-caused hepatocyte improved inflammation. Consistently, increased phosphorylations AMPK, promoted Nrf2 nuclear translocation livers APAP-intoxicated mice. Hepatic transcriptions HO-1 GCLC, downstream antioxidant genes Nrf2, were also response ERS. Our results collectively indicated effectively attenuates activating cascade. Upregulated plays crucial role ERS-mediated LKB1.

Language: Английский

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Water extract of earthworms mitigates mouse liver fibrosis by potentiating hepatic LKB1/Nrf2 axis to inhibit HSC activation and hepatocyte death

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 321, P. 117495 - 117495

Published: Nov. 26, 2023

Language: Английский

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Comparative studies on the antioxidant, anticancer and anti-inflammatory activities of green tea, orthodox black tea and CTC black tea

Journal of Food Science and Technology, Journal Year: 2023, Volume and Issue: 61(7), P. 1315 - 1325

Published: Dec. 19, 2023

Language: Английский

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Signaling pathways that activate hepatic stellate cells during liver fibrosis

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 18, 2024

Liver fibrosis is a complex process driven by various factors and key feature of chronic liver diseases. Its essence tissue remodeling caused excessive accumulation collagen other extracellular matrix. Activation hepatic stellate cells (HSCs), which are responsible for production, plays crucial role in promoting the progression fibrosis. Abnormal expression signaling pathways, such as TGF-β/Smads pathway, contributes to HSCs activation. Recent studies have shed light on these providing valuable insights into development Here, we will review six pathways that been studied more recent years.

Language: Английский

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Ergothioneine suppresses hepatic stellate cell activation via promoting Foxa3-dependent potentiation of the Hint1/Smad7 cascade and improves CCl₄-induced liver fibrosis in mice

Food & Function, Journal Year: 2023, Volume and Issue: 14(23), P. 10591 - 10604

Published: Jan. 1, 2023

EGT is a bioactive compound derived from certain edible mushrooms. Here, we showed that inhibits HSC activation and improves CCl 4 -induced mouse liver fibrosis by promoting nuclear translocation of Foxa3 in HSCs to potentiate the Hint1/Smad7 axis.

Language: Английский

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Discovery of the Natural Bibenzyl Compound Erianin in Dendrobium Inhibiting the Growth and EMT of Gastric Cancer through Downregulating the LKB1-SIK2/3-PARD3 Pathway

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7973 - 7973

Published: July 21, 2024

Erianin, a bibenzyl compound found in dendrobium extract, has demonstrated broad anticancer activity. However, its mechanism of action gastric cancer (GC) remains poorly understood.

Language: Английский

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