Targeting TRIM40 signaling reduces esophagus cancer development: A mechanism involving in protection of oroxylin A

International Immunopharmacology, Год журнала: 2024, Номер 137, С. 112362 - 112362

Опубликована: Июнь 19, 2024

Язык: Английский

Exploring Bioactive Constituents and Pharmacological Effects of Scutellaria baicalensis Georgi: A Review

Natural Product Communications, Год журнала: 2024, Номер 19(8)

Опубликована: Авг. 1, 2024

Scutellaria baicalensis, commonly known as Chinese Skullcap, is a traditional herb with long history of cultural use in medicines. This review focuses on comprehensive summary the morphological description, bioactive compounds, drug-herb interactions, and pharmacological activities well its therapeutic applications. A wide-ranging search using databases such PubMed, Scopus, Google Scholar, advanced Web was conducted for data collection from prior studies. The plant root contains major active constituents including flavonoids flavo-glycosides wogonin, baicalein, baicalin, oroxylin A, scutellarein, norwogonin. These compounds have demonstrated variety activities, combating inflammation, oxidative stress, cancer, neuronal disorders, liver disorders. Skullcap represents promising avenue potential pharmacotherapeutic formulation advancement, emphasizing need further scientific exploration clinical trials.

Язык: Английский

Efficacy of Oroxylin A in ameliorating renal fibrosis with emphasis on Sirt1 activation and TGF-β/Smad3 pathway modulation

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Дек. 2, 2024

Renal fibrosis poses a serious threat to human health. At present, there are few types of traditional Chinese medicine used treat this disease, and Oroxylin A (OA), as natural product with multiple biological activities, is expected be for the treatment renal fibrosis.

Язык: Английский