Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Авг. 5, 2024
Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic globally, characterized by the accumulation of lipids, oxidative stress, and mitochondrial dysfunction in liver.
Язык: Английский
Biomolecules, Год журнала: 2025, Номер 15(1), С. 140 - 140
Опубликована: Янв. 17, 2025
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic and is closely associated with metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), syndrome. However, effective treatment strategies for NAFLD are still lacking. In recent years, progress been made in understanding pathogenesis of NAFLD, identifying multiple therapeutic targets providing new directions drug development. This review summarizes advances focusing on mechanisms action natural products, small-synthetic-molecule drugs, combination therapy strategies. aims to provide insights treating NAFLD.
Язык: Английский
Процитировано
2
Steroids, Год журнала: 2025, Номер unknown, С. 109602 - 109602
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Toxicology Reports, Год журнала: 2025, Номер unknown, С. 102047 - 102047
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2025, Номер 17(10), С. 1643 - 1643
Опубликована: Май 12, 2025
Background/Objectives: Obesity is a major health concern that can lead to various chronic diseases. Little known about the anti-obesity effect of standardized hot water extract from stems Ipomoea batatas (WIB). This study aimed evaluate therapeutic potential WIB as natural alternative conventional treatments by assessing its effects on body weight, fat accumulation, and key metabolic biomarkers in high-fat diet-induced obesity model. Methods: A diet (HFD) induced C57BL/6 mice. The mice were then treated orally with either orlistat (positive control) or WIB. Changes food intake, weight measured, along blood lipid profiles adipokines. Western blot analyses conducted determine protein levels each tissue. H&E staining white adipose tissue liver, gut microbiota composition analyzed. Results: treatment significantly reduced mass compared HFD group demonstrated comparable orlistat. improved adipokine levels. revealed accumulation liver. Also those tissues, restored expression sterol regulatory element-binding protein-1 (SREBP-1) CCAAT/enhancer-binding α (C/EBPα) increased AMP-activated kinase (AMPK) phosphorylation. In brown tissue, enhanced AMPK phosphorylation upregulated thermogenic-related proteins, including peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α), receptor (PPARα), sirtuin 1 (SIRT1), uncoupling (UCP-1), cytochrome C oxidase subunit 4 (COX-IV). Analysis normalized β-diversity reversed HFD-induced phyla imbalances (notably Bacteroidetes, Firmicutes, Proteobacteria). Conclusions: By reducing adiposity under conditions tested murine model, improving markers, favorably modulating microbiota, demonstrates mitigating obesity-related risks. These findings suggest may serve promising substance for management obesity. Further studies are warranted confirm efficacy explore underlying mechanisms overweight obese humans supplement help manage prevent
Язык: Английский
Процитировано
0
Free Radical Biology and Medicine, Год журнала: 2025, Номер 236, С. 98 - 115
Опубликована: Май 20, 2025
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Авг. 5, 2024
Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic globally, characterized by the accumulation of lipids, oxidative stress, and mitochondrial dysfunction in liver.
Язык: Английский
Процитировано
1