Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 140 - 140

Published: Jan. 17, 2025

Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic and is closely associated with metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), syndrome. However, effective treatment strategies for NAFLD are still lacking. In recent years, progress been made in understanding pathogenesis of NAFLD, identifying multiple therapeutic targets providing new directions drug development. This review summarizes advances focusing on mechanisms action natural products, small-synthetic-molecule drugs, combination therapy strategies. aims to provide insights treating NAFLD.

Language: Английский

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BSS-4, a diosgenin analogue, reduces carrageenan-induced paw inflammation in rat

Steroids, Journal Year: 2025, Volume and Issue: unknown, P. 109602 - 109602

Published: March 1, 2025

Language: Английский

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Liver Disorders and Phytotherapy

Toxicology Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102047 - 102047

Published: May 1, 2025

Language: Английский

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Protective Effects of a Standardized Water Extract from the Stem of Ipomoea batatas L. Against High-Fat Diet-Induced Obesity

Nutrients, Journal Year: 2025, Volume and Issue: 17(10), P. 1643 - 1643

Published: May 12, 2025

Background/Objectives: Obesity is a major health concern that can lead to various chronic diseases. Little known about the anti-obesity effect of standardized hot water extract from stems Ipomoea batatas (WIB). This study aimed evaluate therapeutic potential WIB as natural alternative conventional treatments by assessing its effects on body weight, fat accumulation, and key metabolic biomarkers in high-fat diet-induced obesity model. Methods: A diet (HFD) induced C57BL/6 mice. The mice were then treated orally with either orlistat (positive control) or WIB. Changes food intake, weight measured, along blood lipid profiles adipokines. Western blot analyses conducted determine protein levels each tissue. H&E staining white adipose tissue liver, gut microbiota composition analyzed. Results: treatment significantly reduced mass compared HFD group demonstrated comparable orlistat. improved adipokine levels. revealed accumulation liver. Also those tissues, restored expression sterol regulatory element-binding protein-1 (SREBP-1) CCAAT/enhancer-binding α (C/EBPα) increased AMP-activated kinase (AMPK) phosphorylation. In brown tissue, enhanced AMPK phosphorylation upregulated thermogenic-related proteins, including peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α), receptor (PPARα), sirtuin 1 (SIRT1), uncoupling (UCP-1), cytochrome C oxidase subunit 4 (COX-IV). Analysis normalized β-diversity reversed HFD-induced phyla imbalances (notably Bacteroidetes, Firmicutes, Proteobacteria). Conclusions: By reducing adiposity under conditions tested murine model, improving markers, favorably modulating microbiota, demonstrates mitigating obesity-related risks. These findings suggest may serve promising substance for management obesity. Further studies are warranted confirm efficacy explore underlying mechanisms overweight obese humans supplement help manage prevent

Language: Английский

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Celastrus orbiculatus Thunb. extracts and celastrol alleviate NAFLD by preserving mitochondrial function through activating the FGF21/AMPK/PGC-1α pathway

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 5, 2024

Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic globally, characterized by the accumulation of lipids, oxidative stress, and mitochondrial dysfunction in liver.

Language: Английский

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