Frontiers in Molecular Biosciences,
Год журнала:
2024,
Номер
11
Опубликована: Дек. 9, 2024
This
review
provides
an
in-depth
summary
of
the
development
anti-cancer
drugs
for
tumor-associated
macrophages
(TAMs),
with
a
particular
focus
on
and
tissue
specialization
macrophages,
factors
influencing
polarization
M1
M2
mechanistic
insights
underlying
targeting
therapeutic
approaches.
TAMs,
pivotal
in
tumor
microenvironment,
exhibit
notable
plasticity
diverse
functional
roles.
Influenced
by
complex
milieu,
TAMs
polarize
into
M1-type,
which
suppresses
tumors,
M2-type,
promotes
metastasis.
Notably,
M2-TAMs
is
promising
strategy
therapy.
By
emphasizing
importance
as
target
drugs,
this
aims
to
provide
valuable
research
directions
clinicians
researchers.
Molecular Pharmaceutics,
Год журнала:
2023,
Номер
20(11), С. 5921 - 5936
Опубликована: Окт. 24, 2023
Prostate
cancer
(PCa)
is
the
most
prevalent
cause
of
deaths
in
men.
Conventional
strategies,
such
as
surgery,
radiation,
or
chemotherapy,
face
challenges
including
poor
prognosis
and
resistance.
Therefore,
development
new
improved
strategies
vital
to
enhance
patient
outcomes.
Recently,
immunotherapy
has
shown
potential
treatment
a
range
cancers,
PCa.
Tumor-associated
macrophages
(TAMs)
play
an
important
role
tumor
microenvironment
(TME)
reprogramming
TAMs
associated
with
remodeling
TME.
The
colony-stimulating
factor-1/colony
stimulating
factor-1
receptor
(CSF-1/CSF-1R)
signaling
pathway
closely
related
polarization
TAMs.
downregulation
CSF-1R,
using
small
interfering
RNA
(siRNA),
been
achieve
TAMs,
from
immunosuppressive
M2
phenotype
immunostimulatory
M1
one.
To
maximize
specific
cellular
delivery
macrophage-targeting
peptide,
M2pep,
was
formulated
amphiphilic
cationic
β-Cyclodextrin
(CD)
incorporating
CSF-1R
siRNA.
resulting
nanoparticles
(NPs)
increased
macrophage
targeting
both
vitro
vivo,
promoting
release
factors
simultaneously
downregulating
levels
through
TAM
reprogramming.
subsequent
TME
resulted
reduction
growth
subcutaneous
PCa
mouse
model
mainly
mediated
recruitment
cytotoxic
T
cells.
In
summary,
this
M2pep-targeted
CD-based
system
demonstrated
significant
antitumor
efficacy,
thus
presenting
alternative
immunotherapeutic
strategy
for
treatment.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 27, 2024
Gastrointestinal
tumors
are
the
main
causes
of
death
among
patients.
These
mainly
diagnosed
in
advanced
stages
and
their
response
to
therapy
is
unfavorable.
In
spite
development
conventional
therapeutics
including
surgery,
chemotherapy,
radiotherapy
immunotherapy,
treatment
these
still
challenging.
As
a
result,
new
based
on
(nano)biotechnology
have
been
introduced.
Hydrogels
polymeric
3D
networks
capable
absorbing
water
swell
with
favorable
biocompatibility.
application
hydrogels
different
human
diseases,
wide
cancer
has
improved
because
potential
drug
gene
delivery,
boosting
chemotherapy
immunotherapy
as
well
vaccines.
The
current
review
focuses
role
gastrointestinal
tumors.
provide
delivery
drugs
(both
natural
or
synthetic
compounds
co-delivery)
along
delivery.
Along
stimulate
phototherapy
(photothermal
photodynamic
therapy)
suppression
Besides,
ability
for
induction
immune-related
cells
such
dendritic
can
boost
immunotherapy.
For
more
specific
therapy,
stimuli-responsive
types
thermo-
pH-sensitive
self-healing
site
Moreover,
promising
diagnosis,
circulating
tumor
cell
isolation
detection
biomarkers
tumors,
highlighting
importance
clinic.
Hence,
diagnostic
therapeutic
tools
gastrointestimal
Molecules,
Год журнала:
2023,
Номер
28(14), С. 5610 - 5610
Опубликована: Июль 24, 2023
Tumor
immunotherapy,
compared
with
other
treatment
strategies,
has
the
notable
advantage
of
a
long-term
therapeutic
effect
for
preventing
metastasis
and
recurrence
tumors,
thus
holding
great
potential
future
advanced
tumor
therapy.
However,
due
to
poor
water
solubility
immune
modulators
escape
properties
cells,
efficiency
immunotherapy
is
usually
significantly
reduced.
Cyclodextrin
(CD)
been
repeatedly
highlighted
be
probably
one
most
investigated
building
units
cancer
therapy
its
elegant
integration
an
internal
hydrophobic
hollow
cavity
external
hydrophilic
outer
surface.
The
application
CD
provides
new
opportunities
overcoming
aforementioned
obstacles.
there
are
few
published
reviews,
our
knowledge,
summarizing
use
immunotherapy.
For
this
purpose,
paper
comprehensive
summary
on
emphasis
role,
function,
reported
strategies
in
mediating
This
review
summarizes
research
progress
made
using
which
will
facilitate
generation
various
CD-based
immunotherapeutic
delivery
systems
superior
anticancer
efficacy.
