Annual Review of Biomedical Engineering,
Год журнала:
2024,
Номер
26(1), С. 307 - 330
Опубликована: Март 1, 2024
There
is
nothing
like
a
global
pandemic
to
motivate
the
need
for
improved
respiratory
treatments
and
mucosal
vaccines.
Stimulated
by
COVID-19
pandemic,
pulmonary
aerosol
drug
delivery
has
seen
flourish
of
activity,
building
on
prior
decades
innovation
in
particle
engineering,
inhaler
device
technologies,
clinical
understanding.
As
such,
field
expanded
into
new
directions
working
toward
efficient
increasingly
complex
cargos
address
wider
range
diseases.
This
review
seeks
highlight
recent
innovations
approaches
personalize
inhalation
delivery,
deliver
cargos,
diversify
targets
treated
prevented
through
delivery.
We
aim
inform
readers
emerging
efforts
within
predict
where
future
breakthroughs
are
expected
impact
treatment
Journal of Surgical Oncology,
Год журнала:
2024,
Номер
129(7), С. 1390 - 1400
Опубликована: Март 27, 2024
Abstract
Organoids
faithfully
replicate
the
morphological
structure,
physiological
functions,
stable
phenotype
of
source
tissue.
Recent
research
indicates
that
bacteria
can
significantly
influence
initiation,
advancement,
and
treatment
tumors.
This
article
provides
a
comprehensive
review
applications
organoid
technology
in
tumor
research,
relationship
between
genesis
development
tumors,
exploration
impact
on
tumors
their
research.
Brain Research,
Год журнала:
2024,
Номер
1840, С. 149108 - 149108
Опубликована: Июль 2, 2024
One
of
the
most
common
entry
gates
for
systemic
infection
is
lung.
In
humans,
pulmonary
infections
can
lead
to
significant
neurological
impairment,
ranging
from
acute
sickness
behavior
long-term
disorders.
Surfactant
proteins
(SP),
essential
parts
innate
immune
defense,
have
been
detected
in
brain
rats
and
humans.
Recent
evidence
suggests
that
SP-A,
major
protein
component
surfactant,
also
plays
a
functional
role
modulating
neuroinflammation.
This
study
aimed
determine
whether
SP-A
deficiency
affects
inflammatory
response
adult
mice
during
infection.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 12, 2024
Current
needle-based
vaccination
for
respiratory
viruses
is
ineffective
at
producing
sufficient,
long-lasting
local
immunity
in
the
elderly.
Direct
pulmonary
delivery
to
resident
immune
cells
can
create
long-term
mucosal
responses.
However,
criteria
drug
vehicle
design
rules
that
overcome
age-specific
changes
cell
functions
have
yet
be
established.
