Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Год журнала:
2024,
Номер
163, С. 106828 - 106828
Frontiers in Microbiology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 3, 2025
The
global
crisis
of
antimicrobial
resistance
(AMR)
is
escalating
due
to
the
misuse
and
overuse
antibiotics,
slow
development
new
therapies,
rise
multidrug-resistant
(MDR)
infections.
Traditional
antibiotic
treatments
face
limitations,
including
resistance,
disruption
microbiota,
adverse
side
effects,
environmental
impact,
emphasizing
urgent
need
for
innovative
alternative
antibacterial
strategies.
This
review
critically
examines
naturally
derived
biopolymers
with
intrinsic
(essential
feature)
properties
as
a
sustainable,
next-generation
traditional
antibiotics.
These
may
address
bacterial
uniquely
by
disrupting
membranes
rather
than
cellular
functions,
potentially
reducing
microbiota
interference.
Through
comparative
analysis
mechanisms
applications
antibiotics
biopolymers,
this
highlights
potential
such
AMR
while
supporting
human
health.
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 18, 2025
Abstract
Gossypetin,
a
flavonoid
present
in
variety
of
fruits,
vegetables
and
herbs,
exhibits
wide
range
pharmacological
effects.
Nevertheless,
its
application
cancer
therapy
is
limited
due
to
low
bioavailability
at
the
tumor
site
because
poor
solubility
water
slow
dissolution
rate.
To
improve
therapeutic
efficacy
GTIN,
emergent
research
looking
into
using
nanocarriers.
Silk
fibroin,
from
Bombyx
mori
silkworm,
biocompatible
biodegradable
polymer
with
excellent
mechanical
properties
an
amphiphilic
chemistry
that
make
it
promising
candidate
as
controlled
release
drug
system.
The
study
aimed
synthesize
gossypetin-loaded
silk
fibroin
nanoparticles
by
desolvation
method.
GTIN-SFNPs
were
characterized
dynamic
light
scattering,
Fourier
transform
infrared
spectroscopy
thermo-gravimetric
analysis.
also
exhibited
antioxidant,
antibacterial
antibiofilm
activity.
Furthermore,
GTIN-loaded
have
shown
anticancer
activity
against
HCT-116
colorectal
cells
concentration
8μg/mL.
In
addition,
fluorescence-based
staining
methods
was
confirmed
inquest
pattern
cell
death,
inferring
late
apoptotic
bodies,
live/dead
detection
trypan
blue
exclusion
assay.
Western
blotting
analysis
used
confirm
down
regulation
Bcl-2
gene
nanoparticles.
Wound
infections
result
in
delayed
healing,
morbidity,
and
increased
risks
of
sepsis.
Early
detection
wound
can
facilitate
treatment
reduce
the
need
for
excessive
use
antibiotics.
Proteases
are
normally
active
during
healing
process
but
overexpressed
infection
as
part
inflammatory
response.
also
produced
by
bacteria
infecting
wounds,
making
proteases
a
highly
relevant
biomarker
monitoring.
Here,
we
show
fluorescence
turn-on
sensor
real-time
monitoring
protease
activity
advanced
nanocellulose
dressings
rapid
pathogens.
Colloidal
gold
nanoparticles
(AuNPs)
were
adsorbed
on
bacterial
cellulose
(BC)
nanofibrils
using
carefully
optimized
self-assembly
process.
The
AuNPs
could
either
be
homogeneously
incorporated
BC
or
3D
printed
wood-derived
nanofiber
(CNF)
BC-AuNP
ink.
BC-adsorbed
subsequently
functionalized
with
fluorophore-labeled
substrates.
Cleavage
substrates
pathogens
Staphylococcus
aureus
Pseudomonas
aeruginosa
resulted
significant
increase
that
correlated
growth
phase
bacteria.
dressing
integrated
sensors
proteolytic
enable
sensitive
infections,
allowing
optimization
reducing
complications.
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(10), С. 300 - 300
Опубликована: Окт. 7, 2024
Antimicrobial
resistance
(AMR)
poses
a
significant
global
health
threat,
necessitating
the
development
of
novel
antibacterial
strategies.
Serratiopeptidase
(SP),
metalloprotease
produced
by
bacteria
such
as
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12561 - 12561
Опубликована: Ноя. 22, 2024
The
skin
is
the
first
line
of
defense
to
protect
host
from
external
environmental
damage.
When
damaged,
wound
provides
convenience
for
invasion
substances.
prolonged
nonhealing
wounds
can
also
lead
numerous
subsequent
complications,
seriously
affecting
quality
life
patients.
To
solve
this
problem,
proteins
and
peptide
components
that
promote
healing
have
been
discovered
in
animals,
which
act
on
key
pathways
involved
healing,
such
as
PI3K/AKT,
TGF-β,
NF-κ
B,
JAK/STAT
pathways.
So
far,
some
formulations
topical
drug
delivery
developed,
including
hydrogels,
microneedles,
electrospinning
nanofibers.
In
addition,
high-performance
dressings
utilized,
great
potential
healing.
Here,
research
progress
promotion
by
animal-derived
summarized,
future
directions
are
discussed.
