Review on application of silk fibroin hydrogels in the management of wound healing

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 298, P. 140082 - 140082

Published: Jan. 18, 2025

Language: Английский

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Failure or future? Exploring alternative antibacterials: a comparative analysis of antibiotics and naturally derived biopolymers

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 3, 2025

The global crisis of antimicrobial resistance (AMR) is escalating due to the misuse and overuse antibiotics, slow development new therapies, rise multidrug-resistant (MDR) infections. Traditional antibiotic treatments face limitations, including resistance, disruption microbiota, adverse side effects, environmental impact, emphasizing urgent need for innovative alternative antibacterial strategies. This review critically examines naturally derived biopolymers with intrinsic (essential feature) properties as a sustainable, next-generation traditional antibiotics. These may address bacterial uniquely by disrupting membranes rather than cellular functions, potentially reducing microbiota interference. Through comparative analysis mechanisms applications antibiotics biopolymers, this highlights potential such AMR while supporting human health.

Language: Английский

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Nanobubbles create hierarchical pores of cryogels based on chitosan and regenerated silk fibroin: Accelerating oil absorption in constructing foam-templated oleogels

Food Hydrocolloids, Journal Year: 2025, Volume and Issue: 166, P. 111312 - 111312

Published: March 1, 2025

Language: Английский

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Synergistic anticancer activity of gossypetin loaded silk fibroin nanoparticles against colorectal cancer

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Gossypetin, a flavonoid present in variety of fruits, vegetables and herbs, exhibits wide range pharmacological effects. Nevertheless, its application cancer therapy is limited due to low bioavailability at the tumor site because poor solubility water slow dissolution rate. To improve therapeutic efficacy GTIN, emergent research looking into using nanocarriers. Silk fibroin, from Bombyx mori silkworm, biocompatible biodegradable polymer with excellent mechanical properties an amphiphilic chemistry that make it promising candidate as controlled release drug system. The study aimed synthesize gossypetin-loaded silk fibroin nanoparticles by desolvation method. GTIN-SFNPs were characterized dynamic light scattering, Fourier transform infrared spectroscopy thermo-gravimetric analysis. also exhibited antioxidant, antibacterial antibiofilm activity. Furthermore, GTIN-loaded have shown anticancer activity against HCT-116 colorectal cells concentration 8μg/mL. In addition, fluorescence-based staining methods was confirmed inquest pattern cell death, inferring late apoptotic bodies, live/dead detection trypan blue exclusion assay. Western blotting analysis used confirm down regulation Bcl-2 gene nanoparticles.

Language: Английский

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The Promoting Effect of Animal Bioactive Proteins and Peptide Components on Wound Healing: A Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12561 - 12561

Published: Nov. 22, 2024

The skin is the first line of defense to protect host from external environmental damage. When damaged, wound provides convenience for invasion substances. prolonged nonhealing wounds can also lead numerous subsequent complications, seriously affecting quality life patients. To solve this problem, proteins and peptide components that promote healing have been discovered in animals, which act on key pathways involved healing, such as PI3K/AKT, TGF-β, NF-κ B, JAK/STAT pathways. So far, some formulations topical drug delivery developed, including hydrogels, microneedles, electrospinning nanofibers. In addition, high-performance dressings utilized, great potential healing. Here, research progress promotion by animal-derived summarized, future directions are discussed.

Language: Английский

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Bioconjugation of Serratiopeptidase with Titanium Oxide Nanoparticles: Improving Stability and Antibacterial Properties

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(10), P. 300 - 300

Published: Oct. 7, 2024

Antimicrobial resistance (AMR) poses a significant global health threat, necessitating the development of novel antibacterial strategies. Serratiopeptidase (SP), metalloprotease produced by bacteria such as

Language: Английский

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A dialdehyde pullulan cross-linking strategy for immobilizing protamine onto silk fiber surfaces to achieve durable antibacterial function

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136301 - 136301

Published: Oct. 5, 2024

Language: Английский

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Protective effect of water-soluble nervonic acid micro-powder coated with chitosan oligosaccharide and silk fibroin on hippocampal neuronal HT22 cells

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136967 - 136967

Published: Oct. 1, 2024

Language: Английский

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Novel biomimetic sandwich-structured electrospun cardiac patches with moderate adhesiveness and excellent electrical conductivity

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2024, Volume and Issue: 163, P. 106828 - 106828

Published: Nov. 20, 2024

Language: Английский

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