Biomaterials Research,
Год журнала:
2023,
Номер
27(1)
Опубликована: Фев. 9, 2023
Good
osseointegration
is
the
key
to
long-term
stability
of
bone
implants.
Thermoplastic
polyetheretherketone
(PEEK)
has
been
widely
used
in
orthopedics;
however,
its
inherent
biological
inertia
causes
fibrous
tissue
wrap
surface,
which
leads
poor
and
thus
greatly
limits
clinical
applications.Herein,
we
developed
a
facile
yet
effective
surface
modification
strategy.
A
commonly
sulfonation
coupled
with
"cold
pressing"
treatment
presence
porogenic
agent
formed
three-dimensional
hierarchical
porous
structure
on
PEEK
surface.
Subsequently,
effects
vitro
adhesion,
proliferation
differentiation
rat
marrow-derived
mesenchymal
stem
cells
(BMSCs)
were
evaluated.
Finally,
osteoinduction
surface-porous
implant
examined
distal
femoral
defect
model.In
results
showed
that
did
not
significantly
affect
mechanical
performance
cytocompatibility
substance,
modified
substrate
provided
space
for
cellular
ingrowth
enhanced
osteogenic
mineralization
BMSCs.
In
vivo
tests
demonstrated
could
effectively
promote
new
formation
had
higher
bone-implant
contact
rate,
thereby
achieving
good
integration
surrounding
host
bone.
addition,
this
technique
was
also
successfully
medical
interbody
fusion
cage.The
present
study
indicates
topological
morphology
plays
pivotal
role
determining
strategy
by
us
expected
achieve
practical
applications
quickly.
Regenerative Biomaterials,
Год журнала:
2022,
Номер
9
Опубликована: Янв. 1, 2022
Nowadays,
biomaterials
have
evolved
from
the
inert
supports
or
functional
substitutes
to
bioactive
materials
able
trigger
promote
regenerative
potential
of
tissues.
The
interdisciplinary
progress
has
broadened
definition
'biomaterials',
and
a
typical
new
insight
is
concept
tissue
induction
biomaterials.
term
'regenerative
biomaterials'
thus
contents
this
article
are
relevant
yet
beyond
This
review
summarizes
recent
medical
including
metals,
ceramics,
hydrogels,
other
polymers
bio-derived
materials.
As
application
aspects
concerned,
introduces
for
bone
cartilage
regeneration,
cardiovascular
repair,
3D
bioprinting,
wound
healing
cosmetology.
Cell-biomaterial
interactions
highlighted.
Since
global
pandemic
coronavirus
disease
2019,
particularly
mentions
public
health
emergency.
In
last
section,
perspectives
suggested:
(i)
creation
source
innovation;
(ii)
modification
existing
an
effective
strategy
performance
improvement;
(iii)
biomaterial
degradation
regeneration
required
be
harmonious
with
each
other;
(iv)
host
responses
can
significantly
influence
clinical
outcomes;
(v)
long-term
outcomes
should
paid
more
attention
to;
(vi)
noninvasive
approaches
monitoring
Abstract
Tissue
engineering
has
emerged
as
an
interesting
field
nowadays;
it
focuses
on
accelerating
the
auto-healing
mechanism
of
tissues
rather
than
organ
transplantation.
It
involves
implanting
In
Vitro
cultured
initiative
tissue
or
a
scaffold
loaded
with
regenerating
ingredients
at
damaged
area.
Both
techniques
are
based
use
biodegradable
,
biocompatible
polymers
scaffolding
materials
which
either
derived
from
natural
(e.g.
alginates,
celluloses,
and
zein)
synthetic
sources
PLGA,
PCL,
PLA).
This
review
discusses
in
detail
recent
applications
different
biomaterials
highlighting
targeted
besides
vitro
vivo
key
findings.
As
well,
smart
chitosan)
fascinating
candidates
they
capable
elucidating
chemical
physical
transformation
response
to
external
stimuli
temperature,
pH,
magnetic
electric
fields).
Recent
trends
summarized
this
stem
cells,
3D
printing
techniques,
most
4D
approach
relies
produce
dynamic
resembling
tissue.
Furthermore,
application
advanced
provides
hope
for
researchers
recognize
COVID-19/host
interaction,
also,
presents
promising
solution
rejuvenate
destroyed
lung
tissues.
Graphical
abstract
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(43)
Опубликована: Июль 2, 2023
Abstract
Osteochondral
regeneration
remains
a
great
challenge
due
to
the
limited
self‐healing
ability
and
complexity
of
its
hierarchical
structure
composition.
Mg
2+
hypoxia
are
two
effective
modulators
in
boosting
chondrogenesis.
To
this
end,
double‐layered
scaffold
(D)
consisting
hydrogel
layer
on
porous
cryogel
is
fabricated
mimic
osteochondral
tissue.
An
gradient
incorporated
into
with
hypoxia‐mimicking
deferoxamine
(DFO)
embedded
(D‐Mg‐DFO),
which
remarkably
augments
dual‐lineage
both
cartilage
subchondral
bone.
The
higher
supplementation
from
upper
hydrogel,
associated
situation
small
pore
size,
exhibits
promotive
effects
chondrogenic
differentiation.
lower
bottom
cryogel,
interconnected
macroporous
structure,
achieves
multiple
contributions
stem
cell
migration
bone
marrow
cavity,
matrix
mineralization,
osteogenesis.
Furthermore,
rabbits’
trochlea
defects
established
evaluate
regenerative
outcome.
Compared
control
scaffolds
containing
only
or
DFO,
D‐Mg‐DFO
presents
best
effect
under
synergistic
contribution
factors.
Overall,
work
provides
new
design
toward
an
repair
defect.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(13), С. 3171 - 3190
Опубликована: Янв. 1, 2024
This
review
summarizes
fabrication
strategies
and
manifold
applications
of
electrospun
organic/inorganic
hybrid
nanofibers
in
promoting
the
wound
healing
process.
Bioactive Materials,
Год журнала:
2024,
Номер
34, С. 494 - 519
Опубликована: Янв. 21, 2024
Biomaterial
choice
is
an
essential
step
during
the
development
tissue
engineering
and
regenerative
medicine
(TERM)
applications.
The
selected
biomaterial
must
present
properties
allowing
physiological-like
recapitulation
of
several
processes
that
lead
to
reestablishment
homeostatic
or
organ
function.
Biomaterials
derived
from
extracellular
matrix
(ECM)
many
such
their
use
in
field
has
been
steadily
increasing.
Considering
this
growing
importance,
it
becomes
imperative
provide
a
comprehensive
overview
ECM
biomaterials,
encompassing
sourcing,
processing,
integration
into
TERM
This
review
compiles
main
strategies
used
isolate
process
ECM-derived
biomaterials
as
well
different
techniques
for
its
characterization,
namely
biochemical
chemical,
physical,
morphological,
biological.
Lastly,
some
applications
are
explored
discussed.
Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 22, 2025
Silk
fibroin
(SF)
hydrogels
are
widely
used
in
three-dimensional
(3D)
cell
culture
and
tissue
repair.
Despite
their
importance,
few
studies
have
focused
on
regulating
degradation
further
revealing
the
effects
of
process
encapsulated
behaviors.
Herein,
SF
with
equivalent
initial
properties
different
rates
were
prepared
by
adjusting
ratios
between
hydrogel-encapsulated
normal
microspheres
(MSN)
enzyme-loaded
(MSE).
Further,
experiments
revealed
that
moderately
accelerating
hydrogel
obviously
improved
proliferation
MSCs
during
7
days
culture.
Slightly
promoted
MSC
chondrogenesis.
However,
too
rapid
a
was
unfavorable
for
these
The
relevant
expected
to
provide
useful
strategies
also
afford
new
references
development
excellent
other
protein-based
biomaterials
cartilage
regeneration.
ACS Applied Materials & Interfaces,
Год журнала:
2022,
Номер
14(14), С. 15982 - 15995
Опубликована: Апрель 1, 2022
The
treatment
of
cartilage
injury
and
osteoarthritis
has
been
a
classic
problem
for
many
years.
idea
in
situ
tissue
regeneration
paves
way
osteochondral
repair
vivo.
Herein,
hydrogel
scaffold
linked
with
bioactive
peptides
that
can
selectively
adsorb
transforming
growth
factor
β1
(TGF-β1)
was
hypothesized
to
not
only
afford
cell
ingrowth
space
but
also
induce
the
endogenous
TGF-β1
recruitment
chondrogenesis
promotion.
In
this
study,
bilayered
porous
scaffolds
gelatin
methacryloyl
(GelMA)
hydrogels
as
matrix
were
constructed
via
three-dimensional
(3D)
printing,
which
upper
layer
covalently
bound
lower
blended
hydroxyapatite
subchondral
regeneration.
showed
promising
therapeutic
efficacy
proved
by
osteogenic
induction
vitro
rats
particular,
animal
gait
behavior
recovered
after
regeneration,
corresponding
analysis
demonstrated
promotion
induced
binding
peptides.
Regenerative Biomaterials,
Год журнала:
2022,
Номер
9
Опубликована: Янв. 1, 2022
Abstract
Since
the
pioneering
work
of
Messersmith’s
group
discovering
that
polydopamine
(PDA)
can
serve
to
adhere
many
types
materials,
PDA
coating
has,
as
a
biomimetic
approach,
been
widely
used
enhance
cell
adhesion
by
surface
modification
bind
biologically
active
substances
bioinert
substrate.
Nevertheless,
it
is
unclear
whether
or
not
itself
beneficial
for
cells.
Herein,
we
report
decreases
viability
cells
under
normal
culture
and
observation
conditions.
Such
an
inhibition
effect
was
caused
free
any
inherent
cytotoxicity
this
chemical
substance
but
contact-dependent
phenomenon.
Human
bone
marrow
mesenchymal
stem
were
employed
default
type
tissue
plates
substrate,
although
some
other
substrates
also
examined
confirm
universality
such
‘abnormal’
phenomenon
superstar
molecule.
The
on
exhibited
time
dependence,
decreased
during
found
come
from
decrease
number
instead
average
per
cell.
led
less
global
migration
yet
more
local
motility
Based
concept
‘background
adhesion’
without
significant
motifs
specific
adhesion,
supposed
adhered
better,
which
influenced
mobility
eventually
proliferation.
Hence,
behaviors
are
reasonable,
albeit
bit
complicated.
Advanced Industrial and Engineering Polymer Research,
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 1, 2023
Recent
developments
in
nanomaterials
have
come
to
extensive
use
various
fields,
especially
the
biomedical
industry.
Numerous
significant
obstacles
still
need
be
overcome,
particularly
those
about
utilizing
science,
before
they
can
used
for
medicinal
purposes.
Major
issues
biomedicine
include
biological
functioning,
harmony,
toxic
effects,
and
nano-bio
surface
properties.
Thus,
researchers
may
cutting-edge
characterization
approaches
study
applications.
Two-dimensional
polymers
are
crucial
components
of
systems.
Polymer-based
flexible
more
resistant
chemical
attack
than
other
NPs.
Polymers
easily
form
composite
or
functionalization
with
NPs
improve
their
performance
compared
traditional
The
current
review
article
discussed
nanomaterial
performance,
including
carbon
nanotubes
(CNTs),
graphene,
MXene
polymers-based
state
area
is
illustrated
this
summary
article,
along
applications
significance
approaches.
advanced
methods
examining
interior
geometry,
structure,
morphology
piece
writing,
Transmission
electron
microscopy
(TEM),
Scanning
electronic
(SEM),
Atomic
Force
Microscopy
(AFM),
Magnetic
resonance
force
(MRFM)
X-ray
diffraction
(XRD).
Finally,
authors
associated
