Recent advances in regenerative biomaterials

Regenerative Biomaterials, Год журнала: 2022, Номер 9

Опубликована: Янв. 1, 2022

Nowadays, biomaterials have evolved from the inert supports or functional substitutes to bioactive materials able trigger promote regenerative potential of tissues. The interdisciplinary progress has broadened definition 'biomaterials', and a typical new insight is concept tissue induction biomaterials. term 'regenerative biomaterials' thus contents this article are relevant yet beyond This review summarizes recent medical including metals, ceramics, hydrogels, other polymers bio-derived materials. As application aspects concerned, introduces for bone cartilage regeneration, cardiovascular repair, 3D bioprinting, wound healing cosmetology. Cell-biomaterial interactions highlighted. Since global pandemic coronavirus disease 2019, particularly mentions public health emergency. In last section, perspectives suggested: (i) creation source innovation; (ii) modification existing an effective strategy performance improvement; (iii) biomaterial degradation regeneration required be harmonious with each other; (iv) host responses can significantly influence clinical outcomes; (v) long-term outcomes should paid more attention to; (vi) noninvasive approaches monitoring

Язык: Английский

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Stereo Coverage and Overall Stiffness of Biomaterial Arrays Underly Parts of Topography Effects on Cell Adhesion

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(4), С. 6142 - 6155

Опубликована: Янв. 13, 2023

Surface topography is a biophysical factor affecting cell behaviors, yet the underlying cues are still not clear. Herein, we hypothesized that stereo coverage and overall stiffness of biomaterial arrays on scale single cells underly parts effects adhesion. We fabricated series microarrays (micropillar, micropit, microtube) poly(l-lactic acid) (PLLA) using mold casting based pre-designed templates. The characteristic sizes array units were less than cell, thus, each could sense micropatterns with varied roughness. With human umbilical vein endothelial (HUVECs) as model type, examined spreading areas viabilities different surfaces. "Stereo coverage" was defined to quantify actual fraction topographic surface. Particularly in case high micropillars, confirmed able touch bottom had partially hang among micropillars. Then, our opinion, sensed combining bulk raw material culture medium. Spreading area viability correlated feature prepared particular significantly protruded geometry feather. Cell traction forces exerted micropillars also discussed. These findings provide new insights into surface modifications toward biomedical implants.

Язык: Английский

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Electrospun Scaffolds are Not Necessarily Always Made of Nanofibers as Demonstrated by Polymeric Heart Valves for Tissue Engineering

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(16)

Опубликована: Март 30, 2024

Abstract In the last 30 years, there are ≈60 000 publications about electrospun nanofibers, but it is still unclear whether nanoscale fibers really necessary for tissue engineering scaffolds. The present report puts forward this argument and reveals that compared with microfibers diameter of ≈3 µm (named as “oligo‐micro fiber”) more appropriate scaffolds owing to their better cell infiltration ability caused by larger pores available nuclear deformation. To further increase pore sizes, poly(ε‐caprolactone) (PCL) fabricated using latticed collectors meshes. Fiber orientation leads sufficient mechanical strength albeit increases porosity. exhibit good biocompatibility improve infiltration. Under aortic conditions in vitro, performances satisfactory terms acute systolic hemodynamic functionality, except higher regurgitation fraction enlarged pores. This hierarchical scaffold sparse macropores oligo‐micro filaments provides new insights into design scaffolds, may provide living heart valves regenerative capabilities patients severe valve disease future.

Язык: Английский

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Tissue‐Engineered Therapeutics for Lymphatic Regeneration: Solutions for Myocardial Infarction and Secondary Lymphedema

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Abstract The lymphatic system, which regulates inflammation and fluid homeostasis, is damaged in various diseases including myocardial infarction (MI) breast‐cancer‐related lymphedema (BCRL). Mounting evidence suggests that restoring tissue drainage clearing excess immune cells by regenerating vessels can aid cardiac repair amelioration. Current treatments primarily address symptoms rather than underlying causes due to a lack of regenerative therapies, highlighting the importance system as promising novel therapeutic target. Here cutting‐edge research on engineered tissues, growth factor cell‐based approaches designed enhance lymphangiogenesis restore function explored. Special focus placed how therapies with potential for immediate reconstruction, originally treating BCRL, be applied MI augment reduce heart failure risk. integration these significantly improve patient outcomes promoting repair, preventing pathological remodeling, offering new avenues managing lymphatic‐associated diseases.

Язык: Английский

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Biomaterials for neuroengineering: Applications and challenges

Regenerative Biomaterials, Год журнала: 2025, Номер 12

Опубликована: Янв. 1, 2025

Abstract Neurological injuries and diseases are a leading cause of disability worldwide, underscoring the urgent need for effective therapies. Neural regaining enhancement therapies seen as most promising strategies restoring neural function, offering hope individuals affected by these conditions. Despite their promise, path from animal research to clinical application is fraught with challenges. Neuroengineering, particularly through use biomaterials, has emerged key field that paving way innovative solutions It seeks understand treat neurological disorders, unravel nature consciousness, explore mechanisms memory brain’s relationship behavior, tissue engineering, interfaces targeted drug delivery systems. These including both natural synthetic types, designed replicate cellular environment brain, thereby facilitating repair. This review aims provide comprehensive overview biomaterials in neuroengineering, highlighting functional across basic practice. covers recent developments biomaterial-based products, 2D 3D bioprinted scaffolds cell organoid culture, brain-on-a-chip systems, biomimetic electrodes brain–computer interfaces. also explores artificial synapses networks, discussing applications modeling microenvironments repair regeneration, modulation manipulation integration traditional Chinese medicine. serves guide role advancing neuroengineering solutions, providing insights into ongoing efforts bridge gap between innovation application.

Язык: Английский

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Covalently Grafted Biomimetic Matrix Reconstructs the Regenerative Microenvironment of the Porous Gradient Polycaprolactone Scaffold to Accelerate Bone Remodeling

Small, Год журнала: 2023, Номер 19(19)

Опубликована: Фев. 11, 2023

Abstract Integrating a biomimetic extracellular matrix to improve the microenvironment of 3D printing scaffolds is an emerging strategy for bone substitute design. Here, “soft–hard” implant (BM‐g‐DPCL) consisting bioactive chemically integrated on polydopamine (PDA)‐coated porous gradient scaffold by polyphenol groups constructed. The PDA‐coated “hard” promoted Ca 2+ chelation and mineral deposition; “soft” beneficial migration, proliferation, osteogenic differentiation stem cells in vitro, accelerated endogenous cell recruitment, initiated rapid angiogenesis vivo. results rabbit cranial defect model (Φ = 10 mm) confirmed that BM‐g‐DPCL integration between tissue induced deposition matrix. Proteomics cytokine adhesion, biomineralization, vascularization, formation are major factors accelerate healing. This highly bonded soft–hard components guided construction regenerative scaffold.

Язык: Английский

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Biaxial stretching of polytetrafluoroethylene in industrial scale to fabricate medical ePTFE membrane with node-fibril microstructure

Regenerative Biomaterials, Год журнала: 2023, Номер 10

Опубликована: Янв. 1, 2023

Expanded polytetrafluoroethylene (ePTFE) is promising in biomedical fields such as covered stents and plastic surgery owing to its excellent biocompatibility mechanical properties. However, ePTFE material prepared by the traditional biaxial stretching process with thicker middle thinner sides due bowing effect, which poses a major problem industrial-scale fabrication. To solve this problem, we design an olive-shaped winding roller provide part of tape greater longitudinal amplitude than two sides, so make up for excessive retraction tendency when it transversely stretched. The as-fabricated membrane has, designed, uniform thickness node-fibril microstructure. In addition, examine effects mass ratio lubricant PTFE powder, sintering temperature on performance resultant membranes. Particularly, relation between internal microstructure properties revealed. Besides stable properties, sintered exhibits satisfactory biological We series assessments including

Язык: Английский

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Polyetheretherketone implants with hierarchical porous structure for boosted osseointegration

Biomaterials Research, Год журнала: 2023, Номер 27(1)

Опубликована: Фев. 9, 2023

Good osseointegration is the key to long-term stability of bone implants. Thermoplastic polyetheretherketone (PEEK) has been widely used in orthopedics; however, its inherent biological inertia causes fibrous tissue wrap surface, which leads poor and thus greatly limits clinical applications.Herein, we developed a facile yet effective surface modification strategy. A commonly sulfonation coupled with "cold pressing" treatment presence porogenic agent formed three-dimensional hierarchical porous structure on PEEK surface. Subsequently, effects vitro adhesion, proliferation differentiation rat marrow-derived mesenchymal stem cells (BMSCs) were evaluated. Finally, osteoinduction surface-porous implant examined distal femoral defect model.In results showed that did not significantly affect mechanical performance cytocompatibility substance, modified substrate provided space for cellular ingrowth enhanced osteogenic mineralization BMSCs. In vivo tests demonstrated could effectively promote new formation had higher bone-implant contact rate, thereby achieving good integration surrounding host bone. addition, this technique was also successfully medical interbody fusion cage.The present study indicates topological morphology plays pivotal role determining strategy by us expected achieve practical applications quickly.

Язык: Английский

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Unraveling Endothelial Cell Migration: Insights into Fundamental Forces, Inflammation, Biomaterial Applications, and Tissue Regeneration Strategies

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(4), С. 2054 - 2069

Опубликована: Март 23, 2024

Cell migration is vital for many fundamental biological processes and human pathologies throughout our life. Dynamic molecular changes in the tissue microenvironment determine modifications of cell movement, which can be reflected either individually or collectively. Endothelial (EC) migratory adaptation occurs during several events phenomena, such as endothelial injury, vasculogenesis, angiogenesis, under both normal highly inflammatory conditions. Several advantageous supported by biomaterials. cells are used combination with various types biomaterials to design scaffolds promoting formation mature blood vessels within engineered structures. Appropriate selection, terms scaffolding properties, promote desirable behavior varying degrees. An increasing amount research could lead creation perfect biomaterial regenerative medicine applications. In this review, we summarize state knowledge regarding possible systems inflammation may influence migration. We also describe forces governing motility a specific focus on ECs. Additionally, discuss EC culture, serve enhance proliferative, proangiogenic, promigratory potential cells. Moreover, introduce mechanisms movement highlight significance understanding these context designing that regeneration.

Язык: Английский

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Degradation-Influenced/Induced Self-Assembly of Copolymers with the Combinatory Effects of Changed Molecular Weight and Dispersity

Macromolecules, Год журнала: 2023, Номер 56(7), С. 2619 - 2636

Опубликована: Март 28, 2023

Biodegradable polymers constitute an important class of new materials, in particular biomedical materials. While degradation has been studied extensively as a "destroy" factor material for many years, it is less investigated when treated "construction" to influence dynamic manner. Herein, we examined hydrolyzable amphiphilic block copolymer and found significant reorganization the condensed state copolymers during water. The occurs, depending upon polymer composition experimental condition, both mesoscopically macroscopically, which term "degradation-influenced/induced self-assembly (DISA)". To this end, developed Monte Carlo simulations by introduction hydrolysis probability while keeping chain microrelaxation modes. A series triblock was carried out selective solvent, three types DISA were revealed: micelle 1 2, sol–gel precipitate sol–gel–precipitate. Subsequently, poly(d,l-lactide)-b-poly(ethylene glycol)-b-poly(d,l-lactide) (PLA-PEG-PLA) synthesized, all confirmed experiments aqueous systems different lengths. We that regulated decrease molecular weight (MW) increase dispersity. Here "dispersity" emphasizes not only conventional distribution (MWD) species but also more diversified components after degradation, include blends degradation-generated homopolymers oligomers. employed fluorescence resonance energy transfer confirm percolated network semibald micelles underlying temperature-induced physical hydrogel such systems. present study illustrates can act strategy hierarchical chains.

Язык: Английский

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