Revolutionizing Drug Delivery and Therapeutics: The Biomedical Applications of Conductive Polymers and Composites-Based Systems

Pharmaceutics, Год журнала: 2023, Номер 15(4), С. 1204 - 1204

Опубликована: Апрель 10, 2023

The first conductive polymers (CPs) were developed during the 1970s as a unique class of organic substances with properties that are electrically and optically comparable to those inorganic semiconductors metals while also exhibiting desirable traits conventional polymers. CPs have become subject intensive research due their exceptional qualities, such high mechanical optical properties, tunable electrical characteristics, ease synthesis fabrication, higher environmental stability than traditional materials. Although conducting several limitations in pure state, coupling other materials helps overcome these drawbacks. Owing fact various types tissues responsive stimuli fields has made smart biomaterials attractive for range medical biological applications. For applications, including delivery drugs, biosensors, biomedical implants, tissue engineering, composites attracted significant interest both industry. These bimodalities can be programmed respond internal external stimuli. Additionally, ability deliver drugs concentrations at an extensive range. This review briefly discusses commonly used CPs, composites, processes. Further highlights importance drug along applicability systems.

Язык: Английский

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Stereo Coverage and Overall Stiffness of Biomaterial Arrays Underly Parts of Topography Effects on Cell Adhesion

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(4), С. 6142 - 6155

Опубликована: Янв. 13, 2023

Surface topography is a biophysical factor affecting cell behaviors, yet the underlying cues are still not clear. Herein, we hypothesized that stereo coverage and overall stiffness of biomaterial arrays on scale single cells underly parts effects adhesion. We fabricated series microarrays (micropillar, micropit, microtube) poly(l-lactic acid) (PLLA) using mold casting based pre-designed templates. The characteristic sizes array units were less than cell, thus, each could sense micropatterns with varied roughness. With human umbilical vein endothelial (HUVECs) as model type, examined spreading areas viabilities different surfaces. "Stereo coverage" was defined to quantify actual fraction topographic surface. Particularly in case high micropillars, confirmed able touch bottom had partially hang among micropillars. Then, our opinion, sensed combining bulk raw material culture medium. Spreading area viability correlated feature prepared particular significantly protruded geometry feather. Cell traction forces exerted micropillars also discussed. These findings provide new insights into surface modifications toward biomedical implants.

Язык: Английский

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Fluorescent nano- and microparticles for sensing cellular microenvironment: past, present and future applications

Nanoscale Advances, Год журнала: 2023, Номер 5(17), С. 4311 - 4336

Опубликована: Янв. 1, 2023

Summary of advances in synthesis and application optical ratiometric nano- microparticle sensors for vitro vivo detection pH, oxygen, ROS, ions, biomarkers cell microenvironment.

Язык: Английский

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Angiogenesis in bone tissue engineering via ceramic scaffolds: A review of concepts and recent advancements

Biomaterials Advances, Год журнала: 2024, Номер 159, С. 213828 - 213828

Опубликована: Март 11, 2024

Язык: Английский

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Fused Deposition Modeling 3D-Printed Scaffolds for Bone Tissue Engineering Applications: A Review

Annals of Biomedical Engineering, Год журнала: 2024, Номер 52(5), С. 1184 - 1194

Опубликована: Фев. 28, 2024

Язык: Английский

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Hydrogel Based on Chitosan/Gelatin/Poly(Vinyl Alcohol) for In Vitro Human Auricular Chondrocyte Culture

Polymers, Год журнала: 2024, Номер 16(4), С. 479 - 479

Опубликована: Фев. 8, 2024

Three-dimensional (3D) hydrogels provide tissue-like complexities and allow for the spatial orientation of cells, leading to more realistic cellular responses in pathophysiological environments. There is a growing interest developing multifunctional using ternary mixtures biomedical applications. This study examined biocompatibility suitability human auricular chondrocytes from microtia cultured onto steam-sterilized 3D Chitosan/Gelatin/Poly(Vinyl Alcohol) (CS/Gel/PVA) as scaffolds tissue engineering Hydrogels were prepared polymer ratio (1:1:1) through freezing/thawing freeze-drying sterilized by autoclaving. The macrostructure resulting was investigated scanning electron microscopy (SEM), showing heterogeneous macroporous structure with pore size between 50 500 μm. Fourier-transform infrared (FTIR) spectra showed that three polymers interacted hydrogen bonding amino hydroxyl moieties. profile acids present gelatin hydrogel determined ultra-performance liquid chromatography (UPLC), suggesting majority during formation hydrogel. cytocompatibility, viability, cell growth extracellular matrix (ECM) proteins evaluated demonstrate functionality culture chondrocytes. cytocompatibility confirmed 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, reaching 100% viability after 72 h. Chondrocyte high affinity 14 days, Live/Dead assay. chondrocyte attachment an ECM observed SEM. Immunofluorescence expression elastin, aggrecan type II collagen, main components found elastic cartilage matrix. These results CS/Gel/PVA support culture, these are potential biomaterial applications, aimed at regeneration cartilage.

Язык: Английский

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Electrospun Scaffolds are Not Necessarily Always Made of Nanofibers as Demonstrated by Polymeric Heart Valves for Tissue Engineering

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(16)

Опубликована: Март 30, 2024

Abstract In the last 30 years, there are ≈60 000 publications about electrospun nanofibers, but it is still unclear whether nanoscale fibers really necessary for tissue engineering scaffolds. The present report puts forward this argument and reveals that compared with microfibers diameter of ≈3 µm (named as “oligo‐micro fiber”) more appropriate scaffolds owing to their better cell infiltration ability caused by larger pores available nuclear deformation. To further increase pore sizes, poly(ε‐caprolactone) (PCL) fabricated using latticed collectors meshes. Fiber orientation leads sufficient mechanical strength albeit increases porosity. exhibit good biocompatibility improve infiltration. Under aortic conditions in vitro, performances satisfactory terms acute systolic hemodynamic functionality, except higher regurgitation fraction enlarged pores. This hierarchical scaffold sparse macropores oligo‐micro filaments provides new insights into design scaffolds, may provide living heart valves regenerative capabilities patients severe valve disease future.

Язык: Английский

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Silk Fibroin‐Based Hydrogels Supplemented with Decellularized Extracellular Matrix and Gelatin Facilitate 3D Bioprinting for Meniscus Tissue Engineering

Macromolecular Bioscience, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

The human meniscus transmits high axial loads through the knee joint. This function is compromised upon injury or treatment by meniscectomy. 3D printing of implants has emerged as a promising alternative treatment, it allows for precise mimicry architecture. In this study, silk fibroin (SF) known its excellent mechanical properties used to fabricate hydrogels bioprinting with infrapatellar fat pad-derived mesenchymal stem cells (IFP-MSCs). Extracellular matrix (ECM) derived from bovine menisci and gelatin are added 10% SF promote cell adhesion printability. To examine mutual influence biomaterial, experiments conducted without IFP-MSCs. found crosslinking, β-sheet formation, strength. Variations between printed casted identified number, metabolic activity, secondary structure, Remarkably, IFP-MSCs exhibited compressive Young's modulus 0.16 MPa, which closely resembled that osteoarthritic menisci. After initial low viability, in able proliferate within biomaterial. chondrogenic differentiation medium upregulated expression markers hydrogels, indicating prospects future tissue engineering (TE).

Язык: Английский

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Unified Therapeutic‐Prophylactic Vaccine Demonstrated with a Postoperative Filler Gel to Prevent Tumor Recurrence and Metastasis

Advanced Functional Materials, Год журнала: 2022, Номер 32(40)

Опубликована: Авг. 3, 2022

Abstract Although surgical resection is currently the first choice of clinical treatment for most solid tumors, postoperative cancer recurrence and metastasis are main causes mortality. Herein, authors aim to enable immunotherapy consistent with surgery. To this end, term “therapeutic‐prophylactic vaccine (TPV)” suggested, a TPV‐gel developed as filler after ≈90% tumor eradicate residue (therapeutic) prevent (prophylactic). The made matrix blends two poly( d,l ‐lactide‐ co ‐glycolide)‐ b ‐poly(ethylene glycol)‐ ‐poly( ‐glycolide) block copolymers bioactive substances inorganic calcium salt organic R837. aqueous system polymeric undergoes sol‐gel transition upon heating thus leads an injectable hydrogel filling site; loading CaCl 2 CaCO 3 results in release ions out TPV‐gel, which induces immunogenic cell death residual cells; R837, immune adjuvant, dispersed microcrystal can be released awaken responses. therapeutic prophylactic efficacy confirmed vitro vivo using breast 4T1 mice model.

Язык: Английский

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Research and clinical translation of trilayer stent-graft of expanded polytetrafluoroethylene for interventional treatment of aortic dissection

Regenerative Biomaterials, Год журнала: 2022, Номер 9

Опубликована: Янв. 1, 2022

Abstract The aortic dissection (AD) is a life-threatening disease. transcatheter endovascular repair (EVAR) affords minimally invasive technique to save the lives of these critical patients, and an appropriate stent-graft gets be key medical device during EVAR procedure. Herein, we report trilayer corresponding delivery system used for treatment AD made nitinol stents with asymmetric Z-wave design two expanded polytetrafluoroethylene (ePTFE) membranes. Each inner outer surfaces was covered by ePTFE membrane, membranes were then sintered together. biological studies indicated that had excellent cytocompatibility hemocompatibility in vitro. Both exhibited satisfactory mechanical properties operability. safety efficacy this demonstrated vivo. In nine canine experiments, blood vessels animals implanted stent-grafts good patency, there no thrombus obvious stenosis angiography after implantation 6 months. Furthermore, all clinical cases experienced successful using its postrelease system, 1-year follow-ups preliminary interventional treatment.

Язык: Английский

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