Surgery and Oncology,
Год журнала:
2024,
Номер
14(4), С. 55 - 62
Опубликована: Ноя. 30, 2024
The
landscape
of
cancer
treatment
has
evolved
significantly
with
the
integration
multimodal
approaches,
wherein
surgery
plays
a
pivotal
role.
This
comprehensive
review
examines
dynamic
role
surgical
interventions
within
framework
therapy,
highlighting
historical
advancements,
innovative
techniques,
and
their
synergistic
effects
other
modalities.
We
explore
preoperative,
intraoperative,
postoperative
considerations,
emphasizing
patient
selection,
technological
innovations,
multidisciplinary
collaboration.
Through
case
studies
clinical
trials,
we
illustrate
efficacy
challenges
combining
chemotherapy,
radiotherapy,
emerging
therapies.
Addressing
controversies
future
trends,
this
underscores
necessity
personalized
precision
medicine
in
enhancing
outcomes.
insights
provided
aim
to
guide
clinicians
researchers
optimizing
strategies
multifaceted
care.
Results in Engineering,
Год журнала:
2024,
Номер
23, С. 102720 - 102720
Опубликована: Авг. 10, 2024
Nanostructured
CeO2
was
fabricated
through
a
facile
sonochemical
route
utilizing
cerium
(III)
nitrate
hexahydrate
as
metal
source
and
mentha
extract
novel
capping
agent.
To
our
knowledge,
this
experimental
work
is
the
first
successful
endeavor
for
fabricating
nanostructured
employing
by
an
easy
eco-friendly
route.
The
microstructure
various
characteristics
of
oxide
nanostructure
prepared
were
investigated
using
methods.
This
research
examined
anticancer
effects
green
synthesized
nanoparticles
(CeO2-NPs)
on
cancer
cell
lines
(T98
SHSY5Y)
at
several
concentrations
0.0,
0.05,
0.1,
0.2,
0.4,
0.8
mg/ml
NPs
exposure
time
24/48
h.
obtained
results
presented
cytotoxicity
against
cancerous
lines.
Considering
CeO2-NP's
cells
indicated
significant
toxicity
lines,
these
could
be
applied
in
medicine
developing
new
drug
formulations
Additional
investigations
are
desired
to
reveal
other
biological
applications
normal
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 2049 - 2049
Опубликована: Фев. 26, 2025
Lung
cancer
is
one
of
the
most
common
malignant
cancers
in
countries
and
leading
cause
death
among
diseases
worldwide.
Despite
constant
progress
diagnosis
therapy,
survival
rates
patients
diagnosed
with
lung
remain
unsatisfactory.
Numerous
epidemiological
experimental
studies
conducted
as
early
1970s
confirm
that
important
risk
factor
for
development
long-term
smoking,
which
remains
valid
to
this
day.
In
paper,
authors
present
latest
data
on
epidemiology,
pathogenesis,
treatment
molecular
aspects
cancer.
last
decade,
many
alterations
are
effective
have
been
discovered.
adenocarcinoma,
tyrosine
kinase
inhibitors
were
developed
EGFR
mutations
ALK
ROS1
translocations
approved
use
advanced
stage
adenocarcinomas.
case
squamous
cell
carcinoma,
evaluation
these
not
yet
being
used
clinical
practice.
addition,
there
ongoing
concerning
potential
therapeutic
targets,
such
ROS,
MET,
FGFR,
DDR-2
RET.
Constant
diagnostic
methods
gives
rise
hopes
an
improved
prognosis
In
vitro
diagnostics
(IVD)
makes
clinical
diagnosis
rapid,
simple,
and
noninvasive
to
patients,
playing
a
crucial
role
in
the
early
monitoring
of
diseases.
Metabolic
biomarkers
are
closely
correlated
phenotype
However,
most
IVD
platforms
constrained
by
sensitivity
throughput
assay.
recent
years,
noble-metal-nanoparticle
(NMNP)-assisted
laser
desorption/ionization
mass
spectrometry
(LDI
MS)
has
generated
major
advances
metabolite
analysis,
significantly
improving
sensitivity,
accuracy,
due
unique
optical
electrical
properties
NMNPs.
This
review
systematically
assesses
development
NMNPs
as
LDI
MS
matrices
detection
metabolites
for
application.
The
analysis
several
NMNP
structures,
such
core-shell,
porous,
2D
nanoparticles,
elucidates
their
significant
contribution
enhancement
performance.
Furthermore,
advancements
application
diagnosing
various
systemic
diseases
summarized.
Finally,
prospects
challenges
NMNP-assisted
discussed.
roles
NMNPs'
structure
enhancing
MS-based
metabolic
provides
an
overview
applications,
consequently
offering
comprehensive
insights
researchers
developers
this
field.
Background
Emergency
thoracotomy
(ET)
is
a
critical
intervention
for
traumatic
thoracic
injuries,
often
required
in
patients
with
penetrating
trauma.
The
survival
outcomes
and
the
factors
that
influence
these
remain
an
area
of
interest
trauma
care
providers.
Objective
objective
study
to
assess
rate
influencing
undergoing
emergency
due
Methods
This
retrospective
cross-sectional
was
conducted
surgery,
accident,
department
Lady
Reading
Hospital,
Peshawar,
Pakistan.
A
total
85
who
underwent
following
between
July
2019
June
2024
were
included.
Data
extracted
from
health
information
management
system
(HIMS)
analyzed
using
SPSS.
reviewed
demographic
details,
severity
injury,
operative
postoperative
outcomes.
Statistical
analyses
included
univariate
analysis
chi-square
Fisher's
exact
tests
categorical
data
independent
t-tests
continuous
variables.
Results
mean
age
25.72±7.84
years.
majority
male
(81/85,
95.29%),
while
females
accounted
smaller
proportion
(4/85,
4.71%),
gunshot
most
frequent
cause
injury
(50/85,
58.8%).
time
within
60
minutes
admission,
48±16.5
minutes.
61/85
(71.5%)
had
isolated
24/85
(28.2%)
associated
requiring
concomitant
laparotomy.
overall
mortality
9/85
(10.5%),
7/9
(77.7%)
deaths
occurring
intraoperatively.
Mortality
significantly
higher
combined
laparotomy
procedures.
Prolonged
hospital
stays
transfusion
requirements
observed
wound
victims
Conclusions
has
significant
abdominal
injuries.
Factors
such
as
mechanism
need
additional
procedures
(e.g.,
laparotomy)
Early
proper
injuries
are
crucial
improving
rates
patients.
