Utilizing biomaterial surface properties to improve orthopedic hip implant safety and function in a Safe-by-Design approach

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Фев. 21, 2025

Orthopedic hip implant failure due to adverse events, such as infection, are still a major problem leading high morbidity and mortality. Over the years, various innovative biomaterials have been investigated improve safety functionality of implants. Although novel show initial promising results, many fail at (later) stages testing. We performed literature review serving first step in Safe-by-Design (SbD) approach. SbD is strategy which includes considerations early development that streamlines pre-clinical assessment medical In approach, standard implants (e.g., ISO10993) complemented with insights on cell-biomaterial interactions allowing for better vivo response prediction. As step, these based existing information from literature. Therefore, this review, correlations between biomaterial surface properties key biological processes, relevant success titanium implants, investigated. particular, influence roughness, wettability pore size processes (osseointegration, bacterial adhesion immune response) examined. it was found no ideal combination exist satisfy simultaneously, gathered provide directions safe functional biomaterials. Altogether, an different aspects within approach can thus safety.

Язык: Английский

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Recent Advances and Challenges for Biological Materials in Micro/Nanocarrier Synthesis for Bone Infection and Tissue Engineering

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Roughly 1.71 billion people worldwide suffer from large bone abnormalities, which are the primary cause of disability. Traditional grafting procedures have several drawbacks that impair their therapeutic efficacy and restrict use in clinical settings. A great deal work has been done to create fresh, more potent strategies. Under these circumstances, a crucial technique for regeneration major lesions emerged: tissue engineering (BTE). BTE involves biomaterials can imitate natural design bone. To yet, no biological material able fully meet parameters perfect implantable material, even though varieties created investigated regeneration. Against this backdrop, researchers focused interest over past few years on subject nanotechnology nanostructures regenerative medicine. The ability nanoengineered particles overcome current constraints strategies─such as decreased cell proliferation differentiation, insufficient mechanical strength materials, production extrinsic factors required effective osteogenesis revolutionized field engineering. effects nanoparticles characteristics application materials main topics our review, summarizes most recent vitro vivo research context BTE.

Язык: Английский

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Strategies for Fabricating Multi-Material Bone Tissue Constructs

Bioprinting, Год журнала: 2025, Номер unknown, С. e00405 - e00405

Опубликована: Март 1, 2025

Язык: Английский

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Preparation and Properties of 3D‐Printed Hydrogel‐Embedded PLA Composite Scaffolds

Journal of Applied Polymer Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

ABSTRACT This study presents the development of a biodegradable composite scaffold designed to address limitations associated with conventional bone repair materials. 3D‐printing filaments were developed using fish scale powder (FSP) or scale‐derived hydroxyapatite (HAP), polylactic acid (PLA), and polycaprolactone (PCL), focus on optimal effect 5 wt% HAP mechanical properties PLA. Composite scaffolds further prepared by integrating 3D‐printed grid chitosan/gelatin hydrogels through vacuum freeze‐drying. The evaluated property tests, thermal analysis (including DSC TGA), absorption rate assessments (conducted via immersion experiments in various solutions), surface morphology analyses (utilizing SEM EDS). results show that addition significantly improves filaments. high exhibited HAP/PLA suggests improved biocompatibility its potential for vivo tissue fluid absorption. showed visible mineralization degradation after 10 days simulated body (SBF), highlighting regeneration.

Язык: Английский

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Advancing 3D Dental Implant Finite Element Analysis: Incorporating Biomimetic Trabecular Bone with Varied Pore Sizes in Voronoi Lattices

Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(4), С. 94 - 94

Опубликована: Апрель 4, 2024

The human mandible's cancellous bone, which is characterized by its unique porosity and directional sensitivity to external forces, crucial for sustaining biting stress. Traditional computer- aided design (CAD) models fail fully represent the bone's anisotropic structure thus depend on simple isotropic assumptions. For our research, we use latest versions of nTOP 4.17.3 Creo Parametric 8.0 software make biomimetic Voronoi lattice that accurately reflect complex geometry mechanical properties trabecular bone. bone modeled in this work using models. porosities range from 70% 95%, can be achieved changing pore sizes 1.0 mm, 1.5 2.0 2.5 mm. Finite element analysis (FEA) was used examine displacements, stresses, strains acting dental implants with a buttress thread, abutment, retaining screw, load surface. results show model depicts anatomy jaw, compared standard solid block ideal size 2 taking account both von Mises stress distribution over implant, screw retention, cortical micromotions. This displayed balanced performance successfully matching natural characteristics. Advanced FEA improves biomechanical understanding how bones interact creating more accurate biological problems dynamic loading situations. makes engineering better.

Язык: Английский

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Exosome-Laden Hydrogels as Promising Carriers for Oral and Bone Tissue Engineering: Insight into Cell-Free Drug Delivery

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 11092 - 11092

Опубликована: Окт. 15, 2024

Mineralization is a key biological process that required for the development and repair of tissues such as teeth, bone cartilage. Exosomes (Exo) are subset extracellular vesicles (~50–150 nm) secreted by cells contain genetic material, proteins, lipids, nucleic acids, other substances have been extensively researched oral tissue regeneration. However, Exo-free biomaterials or exosome treatments exhibit poor bioavailability lack controlled release mechanisms at target site during By encapsulating Exos into like hydrogels, these disadvantages can be mitigated. Several engineering approaches, those wound healing processes in diabetes mellitus, treatment osteoarthritis (OA) cartilage degeneration, intervertebral disc cardiovascular diseases, etc., exploited to deliver exosomes containing variety therapeutic diagnostic cargos tissues. Despite significant efficacy Exo-laden their use mineralized tissues, tissue, very sparse. This review aims explore summarize literature related potential hydrogel-encapsulated provides insight practical procedures future clinical techniques.

Язык: Английский

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Hydroxypropyl methylcellulose/sodium alginate/hydroxyapatite nano biomaterial enriched with zinc to promote bone tissue augmentation

Journal of Molecular Structure, Год журнала: 2024, Номер 1310, С. 138282 - 138282

Опубликована: Апрель 11, 2024

Язык: Английский

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A structural curve with reduced stress concentration and its elastic–plastic failure analysis

Engineering Failure Analysis, Год журнала: 2024, Номер 162, С. 108339 - 108339

Опубликована: Апрель 21, 2024

Язык: Английский

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Osteogenic Potential of Adipose Stem Cells on Hydroxyapatite-Functionalized Decellularized Amniotic Membrane

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 240, С. 113974 - 113974

Опубликована: Май 16, 2024

Язык: Английский

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Surface characterization and antibacterial efficiency of well-ordered TiO2 nanotube surfaces fabricated on titanium foams

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Янв. 5, 2024

Abstract Titanium (Ti)-based implants are not compatible enough due to their bio-inert character, insufficient antibacterial capabilities and stress-shielding problem for dental orthopaedic implant applications. Thus, this work focused fabricate, analyze improve properties titanium dioxide (TiO 2 ) nanotube array surfaces on Ti foam by anodic oxidation (AO) process. The well-ordered arrays with approximately 75 nm were successfully fabricated at 40 V 1 h foams. O observed as major elements AO-coated surfaces. In addition, the existence of TiO structure was proved For potential orthopedic application, in vitro investigated versus Staphylococcus aureus Escherichia coli . both bacteria, surface greater than bare foam. bacterial inhibition improved 53.3% 69.4% compared

Язык: Английский

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