Journal of the Australian Ceramic Society, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 26, 2024
Language: Английский
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13
Published: Feb. 21, 2025
Orthopedic hip implant failure due to adverse events, such as infection, are still a major problem leading high morbidity and mortality. Over the years, various innovative biomaterials have been investigated improve safety functionality of implants. Although novel show initial promising results, many fail at (later) stages testing. We performed literature review serving first step in Safe-by-Design (SbD) approach. SbD is strategy which includes considerations early development that streamlines pre-clinical assessment medical In approach, standard implants (e.g., ISO10993) complemented with insights on cell-biomaterial interactions allowing for better vivo response prediction. As step, these based existing information from literature. Therefore, this review, correlations between biomaterial surface properties key biological processes, relevant success titanium implants, investigated. particular, influence roughness, wettability pore size processes (osseointegration, bacterial adhesion immune response) examined. it was found no ideal combination exist satisfy simultaneously, gathered provide directions safe functional biomaterials. Altogether, an different aspects within approach can thus safety.
Language: Английский
Citations
0
ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: March 11, 2025
Roughly 1.71 billion people worldwide suffer from large bone abnormalities, which are the primary cause of disability. Traditional grafting procedures have several drawbacks that impair their therapeutic efficacy and restrict use in clinical settings. A great deal work has been done to create fresh, more potent strategies. Under these circumstances, a crucial technique for regeneration major lesions emerged: tissue engineering (BTE). BTE involves biomaterials can imitate natural design bone. To yet, no biological material able fully meet parameters perfect implantable material, even though varieties created investigated regeneration. Against this backdrop, researchers focused interest over past few years on subject nanotechnology nanostructures regenerative medicine. The ability nanoengineered particles overcome current constraints strategies─such as decreased cell proliferation differentiation, insufficient mechanical strength materials, production extrinsic factors required effective osteogenesis revolutionized field engineering. effects nanoparticles characteristics application materials main topics our review, summarizes most recent vitro vivo research context BTE.
Language: Английский
Citations
0
Bioprinting, Journal Year: 2025, Volume and Issue: unknown, P. e00405 - e00405
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
ABSTRACT This study presents the development of a biodegradable composite scaffold designed to address limitations associated with conventional bone repair materials. 3D‐printing filaments were developed using fish scale powder (FSP) or scale‐derived hydroxyapatite (HAP), polylactic acid (PLA), and polycaprolactone (PCL), focus on optimal effect 5 wt% HAP mechanical properties PLA. Composite scaffolds further prepared by integrating 3D‐printed grid chitosan/gelatin hydrogels through vacuum freeze‐drying. The evaluated property tests, thermal analysis (including DSC TGA), absorption rate assessments (conducted via immersion experiments in various solutions), surface morphology analyses (utilizing SEM EDS). results show that addition significantly improves filaments. high exhibited HAP/PLA suggests improved biocompatibility its potential for vivo tissue fluid absorption. showed visible mineralization degradation after 10 days simulated body (SBF), highlighting regeneration.
Language: Английский
Citations
0
Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(4), P. 94 - 94
Published: April 4, 2024
The human mandible's cancellous bone, which is characterized by its unique porosity and directional sensitivity to external forces, crucial for sustaining biting stress. Traditional computer- aided design (CAD) models fail fully represent the bone's anisotropic structure thus depend on simple isotropic assumptions. For our research, we use latest versions of nTOP 4.17.3 Creo Parametric 8.0 software make biomimetic Voronoi lattice that accurately reflect complex geometry mechanical properties trabecular bone. bone modeled in this work using models. porosities range from 70% 95%, can be achieved changing pore sizes 1.0 mm, 1.5 2.0 2.5 mm. Finite element analysis (FEA) was used examine displacements, stresses, strains acting dental implants with a buttress thread, abutment, retaining screw, load surface. results show model depicts anatomy jaw, compared standard solid block ideal size 2 taking account both von Mises stress distribution over implant, screw retention, cortical micromotions. This displayed balanced performance successfully matching natural characteristics. Advanced FEA improves biomechanical understanding how bones interact creating more accurate biological problems dynamic loading situations. makes engineering better.
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11092 - 11092
Published: Oct. 15, 2024
Mineralization is a key biological process that required for the development and repair of tissues such as teeth, bone cartilage. Exosomes (Exo) are subset extracellular vesicles (~50–150 nm) secreted by cells contain genetic material, proteins, lipids, nucleic acids, other substances have been extensively researched oral tissue regeneration. However, Exo-free biomaterials or exosome treatments exhibit poor bioavailability lack controlled release mechanisms at target site during By encapsulating Exos into like hydrogels, these disadvantages can be mitigated. Several engineering approaches, those wound healing processes in diabetes mellitus, treatment osteoarthritis (OA) cartilage degeneration, intervertebral disc cardiovascular diseases, etc., exploited to deliver exosomes containing variety therapeutic diagnostic cargos tissues. Despite significant efficacy Exo-laden their use mineralized tissues, tissue, very sparse. This review aims explore summarize literature related potential hydrogel-encapsulated provides insight practical procedures future clinical techniques.
Language: Английский
Citations
3
Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1310, P. 138282 - 138282
Published: April 11, 2024
Language: Английский
Citations
2
Engineering Failure Analysis, Journal Year: 2024, Volume and Issue: 162, P. 108339 - 108339
Published: April 21, 2024
Language: Английский
Citations
2
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 240, P. 113974 - 113974
Published: May 16, 2024
Language: Английский
Citations
2
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Jan. 5, 2024
Abstract Titanium (Ti)-based implants are not compatible enough due to their bio-inert character, insufficient antibacterial capabilities and stress-shielding problem for dental orthopaedic implant applications. Thus, this work focused fabricate, analyze improve properties titanium dioxide (TiO 2 ) nanotube array surfaces on Ti foam by anodic oxidation (AO) process. The well-ordered arrays with approximately 75 nm were successfully fabricated at 40 V 1 h foams. O observed as major elements AO-coated surfaces. In addition, the existence of TiO structure was proved For potential orthopedic application, in vitro investigated versus Staphylococcus aureus Escherichia coli . both bacteria, surface greater than bare foam. bacterial inhibition improved 53.3% 69.4% compared
Language: Английский
Citations
1