Intelligent bacteria‐targeting ZIF‐8 composite for fluorescence imaging‐guided photodynamic therapy of drug‐resistant superbug infections and burn wound healing
Exploration,
Год журнала:
2024,
Номер
4(6)
Опубликована: Апрель 19, 2024
Abstract
Infected
burn
wounds
are
characterized
by
persistent
drug‐resistant
bacterial
infection
coupled
with
an
inflammatory
response,
impeding
the
wound‐healing
process.
In
this
study,
intelligent
nanoparticle
system
(CCM+TTD@ZIF‐8
NPs)
was
prepared
using
curcumin
(CCM),
aggregation‐induced
emission
luminogens
(TTD),
and
ZIF‐8
for
infection‐induced
wound
healing.
The
CCM+TTD@ZIF‐8
NPs
showed
multiple
functions,
including
bacteria
targeting,
fluorescence
imaging
pH
response‐guided
photodynamic
therapy
(PDT),
anti‐inflammatory.
positive
charges
of
allowed
targeting
in
infected
wounds,
thereby
realizing
emitting
red
at
site
upon
blue
light
irradiation.
pH‐responsive
characteristics
also
enabled
controllable
CCM
release
onto
site,
promoting
specific
accumulation
ROS
outstanding
bactericidal
efficacy
against
Staphylococcus
aureus
(S.
aureus)
Pseudomonas
aeruginosa
(P.
aeruginosa)
strains
vitro/in
vivo.
Additionally,
due
to
excellent
effect
anti‐inflammatory
properties
combined
irradiation,
regeneration
epidermal
tissue,
angiogenesis,
collagen
deposition
achieved,
accelerating
healing
process
wounds.
Therefore,
multifunctional
provides
great
potential
Язык: Английский
Antibiotic-loaded lactoferrin nanoparticles as a platform for enhanced infection therapy through targeted elimination of intracellular bacteria
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
19(4), С. 100926 - 100926
Опубликована: Май 6, 2024
Intracellular
bacteria
can
multiply
inside
host
cells
and
manipulate
their
biology,
the
efficacy
of
traditional
antibiotic
drug
therapy
for
intracellular
is
limited
by
inadequate
accumulation.
Fighting
against
these
stealthy
has
been
a
long-standing
challenge.
Here,
system
stimuli-responsive
lactoferrin
(Lf)
nanoparticles
prepared
using
protein
self-assembly
technology
to
deliver
broad-spectrum
rifampicin
(Rif)
(Rif@Lf
NPs)
enhanced
infection
through
targeted
elimination
bacteria.
Compared
Rif@BSA
NPs,
Rif@Lf
NPs
specifically
target
macrophages
infected
bacteria,
thus
increasing
accumulation
Rif
within
macrophages.
Subsequently,
with
positive
surface
charge
further
displayed
adherence
released
rapidly
in
redox-responsive
manner.
Combined
antibacterial
activities
Lf
Rif,
showed
abilities
biofilms.
As
result,
high
safety
exhibited
excellent
therapeutic
disease
models
subcutaneous
infection,
sepsis,
bacterial
keratitis.
Taken
together,
antibiotic-loaded
present
promising
platform
combat
pathogen
infections
Язык: Английский
Uptake of Biomimetic Nanovesicles by Granuloma for Photodynamic Therapy of Tuberculosis
ACS Omega,
Год журнала:
2025,
Номер
10(7), С. 6679 - 6688
Опубликована: Фев. 11, 2025
The
antimicrobial
resistance
of
Mycobacterium
tuberculosis
(M.
tuberculosis)
is
a
challenge
in
the
antibiotic
treatment
(TB).
Herein,
we
aimed
to
examine
photodynamic
therapy
for
TB
that
has
low
risk
drug
and
involves
biomimetic
macrophage
membranes
combined
with
photosensitizer,
chlorin
e6
(Ce6;
hereinafter,
C-MV).
We
used
marinum
marinum),
waterborne
pathogen
closely
related
M.
tuberculosis,
which
causes
TB-like
infections
ectotherms
but
not
humans.
mouse
tail
granuloma
model
induced
by
relatively
mature
developed
our
team.
C-MV
nanoparticles
were
prepared
injected
intravenously,
showing
longevity
circulation
due
properties
membrane,
protects
them
from
being
eliminated
blood.
They
then
guided
tuberculous
granulomas,
helping
deliver
precise
therapy.
Ce6
classical
photosensitizer
triggers
production
reactive
oxygen
species
under
laser
irradiation,
causing
death.
showed
good
compatibility
long
time,
effectively
inhibiting
proliferation
infiltration
marinum,
providing
new
paradigm
treatment.
Язык: Английский
Extracellular Vesicle‐Inspired Therapeutic Strategies for the COVID‐19
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(29)
Опубликована: Июнь 25, 2024
Emerging
infectious
diseases
like
coronavirus
pneumonia
(COVID-19)
present
significant
challenges
to
global
health,
extensively
affecting
both
human
society
and
the
economy.
Extracellular
vesicles
(EVs)
have
demonstrated
remarkable
potential
as
crucial
biomedical
tools
for
COVID-19
diagnosis
treatment.
However,
due
limitations
in
performance
titer
of
natural
vesicles,
their
clinical
use
remains
limited.
Nonetheless,
EV-inspired
strategies
are
gaining
increasing
attention.
Notably,
biomimetic
inspired
by
EVs,
possess
specific
receptors
that
can
act
"Trojan
horses,"
preventing
virus
from
infecting
host
cells.
Genetic
engineering
enhance
these
enabling
them
carry
more
receptors,
significantly
specificity
absorbing
novel
coronavirus.
Additionally,
inherit
numerous
cytokine
parent
cells,
allowing
effectively
mitigate
"cytokine
storm"
adsorbing
pro-inflammatory
cytokines.
Overall,
this
strategy
offers
new
avenues
treatment
emerging
diseases.
Herein,
review
systematically
summarizes
current
applications
COVID-19.
The
status
associated
with
implementation
also
discussed.
goal
is
provide
insights
into
design
expand
application
combating
Язык: Английский
A Mucous Permeable Local Delivery Strategy Based on Manganese-Enhanced Bacterial Cuproptosis-like Death for Bacterial Pneumonia Treatment
ACS Nano,
Год журнала:
2024,
Номер
18(46), С. 31923 - 31940
Опубликована: Ноя. 7, 2024
Bacterial
pneumonia
is
one
of
the
most
challenging
global
infectious
diseases
with
high
morbidity
and
mortality.
Considering
antibiotic
abuse
resistance
bacterial
biofilms,
a
variety
metal-based
materials
have
been
developed.
However,
due
to
oxygen
environment
lungs,
some
aerobic
infection
bacteria
tolerance
ROS,
based
on
ROS
may
not
achieve
good
therapeutic
effects.
Inspired
by
sensitivity
cuproptosis
respiratory
cells,
we
designed
copper
composite
antibacterial
nanoparticle
found
that
it
can
effectively
induce
cuproptosis-like
death
in
lungs.
To
address
challenge
Язык: Английский
Silver nanoparticle-loaded Konjac Glucomannan/silk fibroin composite hydrogels for enhanced wound healing
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 140199 - 140199
Опубликована: Янв. 1, 2025
Язык: Английский
Pioneering Topical Ointment Intervention for Unprecedented Antimicrobial and Diabetic Wound Management with Phenylpropanoids and Nano-Silver
Hari Prasath Nagaiah,
Priya Dharsini Periyakaruppan Murugesan,
Chaughule Vrushali Ravindra Rupali
и другие.
The AAPS Journal,
Год журнала:
2024,
Номер
26(4)
Опубликована: Июнь 11, 2024
Язык: Английский
Synergistic Biofilter Tube for Promoting Scarless Tendon Regeneration
Nano Letters,
Год журнала:
2024,
Номер
24(24), С. 7381 - 7388
Опубликована: Июнь 4, 2024
Inspired
by
the
imbalance
between
extrinsic
and
intrinsic
tendon
healing,
this
study
fabricated
a
new
biofilter
scaffold
with
hierarchical
structure
based
on
melt
electrowriting
technique.
The
outer
multilayered
fibrous
connected
porous
characteristics
provides
novel
passageway
for
vascularization
isolates
penetration
of
scar
fibers,
which
can
be
referred
to
as
process.
In
vitro
experiments
found
that
architecture
in
layer
effectively
prevent
cell
infiltration,
whereas
aligned
fibers
inner
promote
recruitment
growth,
well
expression
tendon-associated
proteins
simulated
friction
condition.
It
was
shown
vivo
process
could
healing
reduce
invasion.
Herein,
strategy
indicates
great
potential
design
biomaterials
balancing
realizing
scarless
healing.
Язык: Английский
Biosynthesis of lysosomally escaped apoptotic bodies inhibits inflammasome synthesis in macrophages
Research,
Год журнала:
2024,
Номер
8
Опубликована: Дек. 27, 2024
Hyperglycemia
and
bacterial
colonization
in
diabetic
wounds
aberrantly
activate
Nod-like
receptor
protein
3
(NLRP3)
macrophages,
resulting
extensive
inflammatory
infiltration
impaired
wound
healing.
Targeted
suppression
of
the
NLRP3
inflammasome
shows
promise
reducing
macrophage
disruptions.
However,
challenges
such
as
drug
off-target
effects
degradation
via
lysosomal
capture
remain
during
treatment.
In
this
study,
engineered
apoptotic
bodies
(BHB-dABs)
derived
from
adipose
stem
cells
loaded
with
β-hydroxybutyric
acid
(BHB)
were
synthesized
biosynthesis.
These
vesicles
target
M1-type
which
highly
express
folic
microenvironment,
facilitate
escape
through
1,2-distearoyl-sn-propyltriyl-3-phosphatidylethanolamine-polyethylene
glycol
functionalization,
may
enhance
efficacy
inhibition
for
managing
wounds.
vitro
studies
demonstrated
biocompatibility
BHB-dABs,
their
selective
targeting
ability
to
release
BHB
within
microenvironment
signaling.
nanovesicles
exhibited
escape,
anti-inflammatory,
mitochondrial
protection,
endothelial
cell
vascularization
properties.
vivo
experiments
that
BHB-dABs
recovery
inflammation
angiogenesis,
accelerating
functionalized
efficiently
deliver
inhibitors
using
a
dual
strategy
macrophages
promoting
escape.
This
approach
represents
novel
therapeutic
effectively
treating
chronic
Язык: Английский