Rapid
urbanization
is
underway
in
China.
However,
the
impact
of
on
frailty
remains
unclear.
This
study
aims
to
investigate
relationship
between
and
among
middle-aged
older
adults.
We
analyzed
nationally
representative
data
from
China
Health
Retirement
Longitudinal
Study
(CHARLS)
spanning
2011
2018.
After
applying
inclusion
exclusion
criteria,
10,758
non-frail
individuals
at
baseline
were
analyzed.
The
exposure
interest
was
comprehensive
level.
Urbanization
level
(0.072–0.689)
assessed
using
entropy
method.
Frailty
index
(FI),
which
ranges
0
100.
defined
as
FI
≥
25,
urbanization–frailty
association
-
restricted
cubic
spline
(RCS)
expressions
Cox
proportional
hazards
models.
Least
absolute
shrinkage
selection
operator
(LASSO)
regression
employed
evaluate
major
factors
associated
with
frailty.
results
revealed
a
U-shaped
nonlinear
incidence,
turning
point
0.3
(Pnonlinear
<
0.001).
In
model,
for
scores
below
0.3,
each
ten-percentile
increase
an
HR
0.871
(95%
CI
0.843–0.900,
P
0.05).
Conversely,
or
above
had
1.178
1.053–1.319,
0.05)
per
increase.
subgroup
analysis
participants
there
significant
interaction
current
work
status
subgroups
dyslipidemia.
LASSO
showed
that,
total
retail
sales
(coefficient
=
−
0.129)
capita
income
0.071)
most
protective
against
For
key
increased
risk
included
number
college
students
10,000
people
0.080)
proportion
built-up
land
urban
area
0.060).
incidence.
Factors
such
consumer
goods
capita,
disposable
residents,
may
be
formulating
strategy
prevention.
Molecules,
Год журнала:
2025,
Номер
30(5), С. 994 - 994
Опубликована: Фев. 21, 2025
Per-
and
polyfluoroalkyl
substances
(PFASs)
have
been
widely
used
in
the
production
of
consumer
products
globally
due
to
excellent
water
oil
resistance
anti-fouling
properties.
The
multiple
toxic
effects
some
PFASs
also
pose
a
threat
human
health
ecosystem,
frequent
use
certain
increased
risk
exposure
PFASs.
More
data
on
occurrence,
concentration,
migration
is
urgently
needed
address
possible
risks
posed
by
products.
This
paper
reviews
PFAS
concentrations
found,
characteristics
known,
arising
from
several
types
over
last
five
years.
considered
here
include
food
contact
materials,
textiles,
disposable
personal
hygiene
influence
different
factors
process
these
are
summarized
discussed.
Additionally,
main
approaches
models
assessment
evaluated
summarized.
Current
challenges
future
research
prospects
this
field
discussed
with
view
providing
guidance
for
regulation
Advanced Healthcare Materials,
Год журнала:
2021,
Номер
11(7)
Опубликована: Ноя. 23, 2021
Humans
are
constantly
exposed
to
exogenous
chemicals
throughout
their
life,
which
can
lead
a
multitude
of
negative
health
impacts.
Advanced
materials
play
key
role
in
preventing
or
mitigating
these
impacts
through
wide
variety
applications.
The
tunable
properties
hydrogels
and
hydrogel
nanocomposites
(e.g.,
swelling
behavior,
biocompatibility,
stimuli
responsiveness,
functionality,
etc.)
have
deemed
them
ideal
platforms
for
removal
environmental
contaminants,
detoxification,
reduction
body
burden
from
chemical
exposures
prevention
disease
initiation,
advanced
treatment
chronic
diseases,
including
cancer,
diabetes,
cardiovascular
disease.
In
this
review,
three
main
junctures
where
the
use
nanocomposite
intervene
positively
impact
human
highlighted:
1)
2)
prophylactic
treatments
prevent
3)
treating
diseases
after
they
developed.
Forests,
Год журнала:
2023,
Номер
14(2), С. 244 - 244
Опубликована: Янв. 28, 2023
Urban
park
waterfront
green
spaces
provide
positive
mental
health
benefits
to
the
public.
In
order
further
explore
specific
influence
mechanism
between
landscape
elements
and
public
psychological
response,
36
typical
areas
in
Xihu
Park
Zuohai
Gulou
District,
Fuzhou
City,
Fujian
Province,
China,
were
selected
for
this
study.
We
used
semantic
segmentation
technology
quantitatively
decompose
scenes
of
obtained
a
response
evaluation
using
virtual
reality
combined
with
questionnaire
interviews.
The
main
results
showed
that:
(1)
Pyramid
Scene
Parsing
Network
(PSPNet)
is
model
suitable
quantitative
decomposition
urban
space;
(2)
public’s
overall
responses
was
relatively
high,
dimension
scoring
highest;
(3)
different
significant
differences
four
dimensions.
Among
elements,
plant
layer,
pavement
proportion,
commercial
facilities
all
have
an
impact
on
dimensions;
(4)
contribution
rate
element
types
shown
as
spatial
(37.9%)
>
facility
(35.1%)
natural
(25.0%)
construction
(2.0%).
reveal
psychology
behavior.
Meanwhile,
it
provides
links
methods
that
can
be
involved
planning
design
space,
also
emerging
technical
support
objective
data
reference
subsequent
research.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Янв. 10, 2024
Abstract
Several
studies
have
reported
an
increased
risk
of
chronic
kidney
disease
(CKD)
outcomes
after
long-term
exposure
(more
than
1
year)
to
particulate
matter
with
aerodynamic
diameter
≤
2.5
µm
(PM
).
However,
the
conclusions
remain
inconsistent.
Therefore,
we
conducted
this
meta-analysis
examine
association
between
PM
and
CKD
outcomes.
A
literature
search
was
in
PubMed,
Scopus,
Cochrane
Central
Register
Controlled
trials,
Embase
for
relevant
published
until
August
10,
2023.
The
main
were
incidence
prevalence
as
well
end-stage
(ESKD).
random-effect
model
meta‐analyses
used
estimate
each
outcome
among
studies.
Twenty
two
identified,
including
14
cohort
studies,
8
cross-sectional
a
total
7,967,388
participants.
This
revealed
that
10
μg/m
3
increment
significantly
associated
risks
both
[adjusted
odds
ratio
(OR)
1.31
(95%
confidence
interval
(CI)
1.24
1.40),
adjusted
OR
CI
1.03
1.67),
respectively].
In
addition,
relationship
ESKD
is
suggestive
but
not
conclusive
(adjusted
1.16;
95%
1.00
1.36).
had
consistent
across
all
subgroups
adjustment
variables.
Our
study
observed
CKD.
more
dedicated
are
required
show
causation
warrants
urgent
action
on
mitigate
global
burden
Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Апрель 10, 2023
Little
is
known
about
the
prevalence
of
chronic
kidney
disease
(CKD)
during
coronavirus
2019
(COVID-19)
pandemic.
We
aimed
to
investigate
long-term
trends
in
CKD
from
South
Korea
including
early
used
data
108,152
Korean
adults
2007
2020
obtained
a
representative
longitudinal
serial
study.
defined
as
condition
when
participant's
estimated
glomerular
filtration
rate
was
<
60
mL/min/1.73
m2,
or
one-time
spot
proteinuria
≥
1
+,
and
then
examined
overall
CKD.
Among
included
(n
=
80,010),
national
6.2%.
The
trend
slope
gradually
increased
2019,
however,
there
sudden
decrease
(2007-2010,
5.1%
[95%
confidence
interval
(CI)
4.7-5.5];
2017-2019,
7.1%
CI
6.6-7.6];
pandemic
period,
6.5%
5.7-7.3];
βdiff,
-
0.19;
95%
0.24
0.13).
among
younger
those
with
poor
medical
utilization
significantly
decreased
This
study
first
large-scale
2020.
Further
research
needed
fully
understand
exact
causes
for
this
decline
identify
healthcare
policy
strategies
preventing
managing
