The Lancet Planetary Health,
Год журнала:
2024,
Номер
8(1), С. e5 - e17
Опубликована: Янв. 1, 2024
BackgroundPerfluoroalkyl
and
polyfluoroalkyl
substances
are
classed
as
endocrine
disrupting
compounds
but
continue
to
be
used
in
many
products
such
firefighting
foams,
flame
retardants,
utensil
coatings,
waterproofing
of
food
packaging.
Perfluoroalkyl
exposure
aberrantly
modulates
lipid,
metabolite,
bile
acid
levels,
increasing
susceptibility
onset
severity
metabolic
diseases,
diabetes
dysfunction-associated
steatotic
liver
disease.
To
date,
most
studies
humans
have
focused
on
perfluoroalkyl-exposure
effects
adults.
In
this
study
we
aimed
show
if
perfluoroalkyls
present
the
human
fetal
they
consequences
for
fetus.MethodsIn
cross-sectional
study,
livers
from
elective
termination
pregnancies
at
Aberdeen
Pregnancy
Counselling
Service,
Aberdeen,
UK,
were
analysed
by
both
targeted
(bile
acids
perfluoroalkyl
substances)
combined
untargeted
(lipids
polar
metabolites)
mass
spectrometry
based
metabolomic
analyses,
well
with
RNA-Seq.
Only
fetuses
normally
progressing
(determined
ultrasound
scan
before
termination),
terminated
non-medical
reasons,
women
older
than
16
years,
fluent
English,
between
11
21
weeks
gestation
collected.
Women
exhibiting
considerable
emotional
distress
or
whose
had
anomalies
identified
excluded.
Stringent
bioinformatic
statistical
methods
partial
correlation
network
analysis,
linear
regression,
pathway
analysis
applied
data
investigate
association
hepatic
pathways.FindingsFetuses
included
collected
Dec
2,
2004,
Oct
27,
2014.
78
study:
all
metabolomics
(40
female
38
male)
57
RNA-Seq
(28
29
male).
Metabolites
associated
these
varied
gestational
age.
Conjugated
markedly
positively
23
amino
acids,
fatty
sugar
derivatives
inversely
exposure,
glycolithocholic
was
quantified
perfluoroalkyl.
Furthermore,
7α-hydroxy-4-cholesten-3-one,
a
marker
synthesis
rate,
strongly
levels
detectable
early
week
12.InterpretationOur
shows
direct
evidence
utero
specific
key
products.
Our
results
provide
that
potential
future
consequences,
manifests
fetus
first
trimester
gestation.
profiles
changes
resemble
those
observed
perinatal
exposures.
Such
exposures
already
linked
susceptibility,
initiation,
progression,
exacerbation
wide
range
diseases.FundingUK
Medical
Research
Council,
Horizon
Europe
Program
European
Union,
Seventh
Framework
Programme
NHS
Grampian
Endowments
grants,
Partnership
Assessment
Risks
Chemicals,
Swedish
Formas,
Novo
Nordisk
Foundation,
Academy
Finland.
Environment International,
Год журнала:
2024,
Номер
186, С. 108577 - 108577
Опубликована: Март 16, 2024
Male
fertility
has
been
declining
worldwide
especially
in
countries
with
high
levels
of
endocrine
disrupting
chemicals
(EDCs).
Per-
and
polyfluorinated
alkyl
Substances
(PFAS)
have
classified
as
EDCs
linked
to
adverse
male
reproductive
health.
The
mechanisms
these
associations
their
implications
on
offspring
health
remain
unknown.
aims
the
current
study
were
assess
effect
PFAS
mixtures
sperm
methylome
transcriptional
changes
metabolic
tissues
(i.e.,
liver
fat).
C57BL/6
mice
exposed
a
mixture
(PFOS,
PFOA,
PFNA,
PFHxS,
Genx;
20
µg/L
each)
for
18-weeks
or
water
control.
Genome-wide
methylation
was
assessed
F0
epidydimal
using
reduced
representation
bisulfite
sequencing
(RRBS)
Illumina
mouse
array,
while
gene
expression
by
bulk
RNA
8-week-old
derived
from
unexposed
females.
resulted
2,861
83
(Illumina)
DMRs
(q
<
0.05).
Functional
enrichment
revealed
that
PFAS-induced
associated
behavior
developmental
pathways
RRBS,
related
lipid
metabolism
cell
signaling.
Additionally,
40
53
differentially
expressed
genes
(DEGs)
fat
males,
9
31
DEGs
females,
respectively.
alterations
cholesterol
mitotic
cycle
regulation
myeloid
leukocyte
migration
offspring,
female
erythrocyte
development
carbohydrate
catabolism
affected
fat.
Our
results
demonstrate
exposure
legacy
newly
emerging
adult
result
aberrant
altered
sex-specific
manner.
These
data
indicate
preconception
males
can
be
transmitted
affect
phenotype
next
generation.
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(4), С. 1842 - 1853
Опубликована: Янв. 16, 2024
Following
its
introduction
as
an
alternative
to
perfluorooctanoic
acid,
hexafluoropropylene
oxide
dimer
acid
(HFPO-DA)
has
been
extensively
detected
in
various
environmental
matrices.
Despite
this
prevalence,
limited
information
is
available
regarding
hepatotoxicity
biomarkers.
In
study,
toxicokinetic
simulations
indicated
that
under
repeated
treatment,
HFPO-DA
mice
serum
reached
a
steady
state
by
the
4th
day.
To
assess
subacute
hepatic
effects
and
identify
potential
biomarkers,
were
administered
orally
at
doses
of
0,
0.1,
0.5,
2.5,
12.5,
or
62.5
mg/kg/d
for
7
d.
Results
revealed
lowest
observed
adverse
effect
levels
0.5
hepatomegaly
2.5
injury.
Serum
metabolomics
analysis
identified
34,
58,
118
differential
metabolites
groups,
respectively,
compared
control
group.
Based
on
weighted
gene
coexpression
network
analysis,
eight
hepatotoxicity-related
identified;
among
them,
kynurenic
(KA)
mouse
exhibited
highest
correlation
with
liver
Furthermore,
liver-targeted
demonstrated
exposure
induced
metabolic
migration
kynurenine
pathway
from
KA
nicotinamide
adenine
dinucleotide,
resulting
activation
endoplasmic
reticulum
stress
nuclear
factor
kappa-B
signaling
pathway.
Notably,
pretreatment
significantly
attenuated
injury
mice,
highlighting
pivotal
roles
HFPO-DA.
Lubricants,
Год журнала:
2024,
Номер
12(4), С. 114 - 114
Опубликована: Март 29, 2024
Per-
and
polyfluoroalkyl
substances
(PFAS),
also
known
as
forever
chemicals,
exhibit
exceptional
chemical
stability
resistance
to
environmental
degradation
thanks
their
strong
C-F
bonds
nonpolar
nature.
However,
widespread
use
persistence
have
a
devastating
impact
on
the
environment.
This
review
examines
roles
of
PFAS
in
tribological
applications,
specifically
lubricants
lubricating
systems.
article
focuses
conventional
advanced
lubricants,
including
ionic
liquids
(ILs)
modern
automotive
vehicles.
The
objective
this
paper
is
provide
comprehensive
overview
adverse
impacts
whilst
acknowledging
outstanding
performance
surface
coatings,
composite
materials,
additives
oils
greases.
pathways
through
which
are
introduced
into
environment
via
systems
such
seals
O-rings
identified,
alongside
subsequent
dispersion
routes
interfaces
across
they
interact.
Furthermore,
we
examine
toxicological
implications
exposure
terrestrial
aquatic
life
forms,
plants,
animals,
humans,
along
with
ecological
consequences
bioaccumulation
biomagnification
trophic
levels
ecosystems.
ends
potential
remediation
strategies
for
use,
treatment
technologies,
biodegradation,
recovery
recycling
methods,
search
more
environmentally
benign
alternatives.
Toxicological Sciences,
Год журнала:
2024,
Номер
200(2), С. 213 - 227
Опубликована: Май 9, 2024
Abstract
Per-
and
polyfluoroalkyl
substances
(PFAS)
have
become
internationally
recognized
over
the
past
three
decades
as
persistent
organic
pollutants
used
in
production
of
various
consumer
industrial
goods.
Research
efforts
continue
to
gauge
risk
that
historically
used,
newly
produced,
PFAS
may
cause
human
health.
Numerous
studies
report
toxic
effects
on
liver
well
increased
serum
cholesterol
levels
adults.
A
major
concern
with
PFAS,
also
dubbed
“forever
chemicals,”
is
they
accumulate
kidney
persist
serum.
The
mechanisms
responsible
for
their
disposition
excretion
humans
are
poorly
understood.
better
understanding
interaction
transporters,
it
pertains
other
xenobiotics,
could
provide
mechanistic
insight
into
health
guide
toward
assessment
compounds
development.
This
review
summarizes
current
state
literature
emerging
relationships
(eg,
substrates,
inhibitors,
modulators
gene
expression)
between
specific
hepatic
transporters.
adaptive
toxicological
responses
hepatocytes
reveal
linkages
pathologies
epidemiological
findings
highlighted.
evidence
suggests
our
molecular
landscape
must
improve
determine
impact
expression
function
hepatocyte
transporters
play
a
key
role
or
xenobiotic
disposition.
From
here,
we
can
assess
what
these
changes
documented
outcomes.
The Lancet Planetary Health,
Год журнала:
2024,
Номер
8(1), С. e5 - e17
Опубликована: Янв. 1, 2024
BackgroundPerfluoroalkyl
and
polyfluoroalkyl
substances
are
classed
as
endocrine
disrupting
compounds
but
continue
to
be
used
in
many
products
such
firefighting
foams,
flame
retardants,
utensil
coatings,
waterproofing
of
food
packaging.
Perfluoroalkyl
exposure
aberrantly
modulates
lipid,
metabolite,
bile
acid
levels,
increasing
susceptibility
onset
severity
metabolic
diseases,
diabetes
dysfunction-associated
steatotic
liver
disease.
To
date,
most
studies
humans
have
focused
on
perfluoroalkyl-exposure
effects
adults.
In
this
study
we
aimed
show
if
perfluoroalkyls
present
the
human
fetal
they
consequences
for
fetus.MethodsIn
cross-sectional
study,
livers
from
elective
termination
pregnancies
at
Aberdeen
Pregnancy
Counselling
Service,
Aberdeen,
UK,
were
analysed
by
both
targeted
(bile
acids
perfluoroalkyl
substances)
combined
untargeted
(lipids
polar
metabolites)
mass
spectrometry
based
metabolomic
analyses,
well
with
RNA-Seq.
Only
fetuses
normally
progressing
(determined
ultrasound
scan
before
termination),
terminated
non-medical
reasons,
women
older
than
16
years,
fluent
English,
between
11
21
weeks
gestation
collected.
Women
exhibiting
considerable
emotional
distress
or
whose
had
anomalies
identified
excluded.
Stringent
bioinformatic
statistical
methods
partial
correlation
network
analysis,
linear
regression,
pathway
analysis
applied
data
investigate
association
hepatic
pathways.FindingsFetuses
included
collected
Dec
2,
2004,
Oct
27,
2014.
78
study:
all
metabolomics
(40
female
38
male)
57
RNA-Seq
(28
29
male).
Metabolites
associated
these
varied
gestational
age.
Conjugated
markedly
positively
23
amino
acids,
fatty
sugar
derivatives
inversely
exposure,
glycolithocholic
was
quantified
perfluoroalkyl.
Furthermore,
7α-hydroxy-4-cholesten-3-one,
a
marker
synthesis
rate,
strongly
levels
detectable
early
week
12.InterpretationOur
shows
direct
evidence
utero
specific
key
products.
Our
results
provide
that
potential
future
consequences,
manifests
fetus
first
trimester
gestation.
profiles
changes
resemble
those
observed
perinatal
exposures.
Such
exposures
already
linked
susceptibility,
initiation,
progression,
exacerbation
wide
range
diseases.FundingUK
Medical
Research
Council,
Horizon
Europe
Program
European
Union,
Seventh
Framework
Programme
NHS
Grampian
Endowments
grants,
Partnership
Assessment
Risks
Chemicals,
Swedish
Formas,
Novo
Nordisk
Foundation,
Academy
Finland.
