A
significant
yet
largely
untapped
reservoir
of
polluted
water
arises
from
groundwater,
where
the
diffusion
PFAS
has
been
shown
to
be
alarmingly
on
rise,
driven
by
prolonged
accumulation
and
restricted
avenues
for
degradation.
Direct
contact
membrane
distillation
(DCMD)
was
used
concentrate
remove
perfluorooctanoic
acid
compounds
contaminated
groundwater
first
time
using
commercially
available
poly(tetrafluoroethylene)
(PTFE)
poly(vinylidene
fluoride)
(PVDF)
membranes.
The
temporal
fouling
propensity
over
DCMD
test
assessed
analysing
morphological
chemical
structural
changes
pristine
Over
120
h
10
mg/L
PFOA-contaminated
model
as
feed,
PVDF
exhibited
a
lower
extent
flux
decline
15%
compared
that
43%
obtained
PTFE
feed
temperature
60
oC.
This
study
provides
practical
route
pre-concentrate
amphiphilic
contaminants
groundwater.
Computational and Structural Biotechnology Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
The
assessment
of
chemicals
and
materials
has
traditionally
been
fragmented,
with
health,
environmental,
social,
economic
impacts
evaluated
independently.
This
disjointed
approach
limits
the
ability
to
capture
trade-offs
synergies
necessary
for
comprehensive
decision-making
under
Safe
Sustainable
by
Design
(SSbD)
framework.
EU
INSIGHT
project
addresses
this
challenge
developing
a
novel
computational
framework
integrated
impact
assessment,
based
on
Impact
Outcome
Pathway
(IOP)
approach.
Extending
Adverse
(AOP)
concept,
IOPs
establish
mechanistic
links
between
chemical
material
properties
their
socio-economic
consequences.
integrates
multi-source
datasets
(including
omics,
life
cycle
inventories,
exposure
models)
into
structured
knowledge
graph
(KG),
ensuring
FAIR
(Findable,
Accessible,
Interoperable,
Reusable)
data
principles
are
met.
is
being
developed
validated
through
four
case
studies
targeting
per-
polyfluoroalkyl
substances
(PFAS),
graphene
oxide
(GO),
bio-based
synthetic
amorphous
silica
(SAS),
antimicrobial
coatings.
These
demonstrate
how
multi-model
simulations,
decision-support
tools,
artificial
intelligence-driven
extraction
can
enhance
predictability
interpretability
impacts.
Additionally,
incorporates
interactive,
web-based
decision
maps
provide
stakeholders
accessible,
regulatory-compliant
risk
sustainability
assessments.
By
bridging
toxicology,
modeling,
analysis,
advances
scalable,
transparent,
data-driven
SSbD.
aligns
European
Green
Deal
global
goals,
promoting
safer,
more
sustainable
innovation
in
an
integrated,
mechanistic,
computationally
advanced
Vaccines,
Год журнала:
2025,
Номер
13(5), С. 444 - 444
Опубликована: Апрель 23, 2025
Replication-competent
virus
particles
hold
significant
therapeutic
potential
in
application
as
oncolytic
viruses
or
cancer
vaccines.
Ensuring
the
viral
integrity
of
these
is
crucial
for
their
infectivity,
safety,
and
efficacy.
Enveloped
particles,
particular,
offer
large
gene
insert
capacities
customizable
target
specificity.
However,
sensitivity
to
environmental
factors
presents
challenges
bioprocessing,
potentially
compromising
high
quality
standards
cost-effective
production.
This
review
provides
an
in-depth
analysis
purification
process
steps
replication-competent
enveloped
emphasizing
importance
maintaining
integrity.
It
evaluates
bioprocessing
methods
from
cell
culture
harvest
final
sterile
filtration,
including
centrifugation,
chromatographic,
filtration
techniques.
Furthermore,
manuscript
delves
into
formulation
storage
strategies
necessary
preserve
functional
structural
ensuring
long-term
stability
To
assess
impact
on
determine
integrity,
advanced
analytical
are
required.
commonly
used
assessing
such
infectious
titer
assays,
total
particle
quantification,
analysis.
By
providing
a
comprehensive
overview
current
state
this
aims
guide
researchers
industry
professionals
developing
robust
efficient
processes.
The
insights
gained
will
contribute
advancement
virus-based
therapeutics,
ultimately
supporting
development
safe,
effective,
economically
viable
treatments
various
diseases.
Industrial Lubrication and Tribology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
Purpose
This
study
aims
to
extend
the
service
life
and
applicability
under
ultraviolet
(UV)
irradiation
conditions,
authors
reveal
strong
UV
resistance
of
dibenzoylmethane
molybdenum
(MDBM)
in
aluminum-based
greases
by
analyzing
effect
radiation
on
rheological
properties,
antioxidant
properties
absorption.
Meanwhile,
evaluate
tribological
MDBM
different
sliding
modes
applied
loads
greases.
Design/methodology/approach
In
this
work,
designed
synthesized
an
S-
P-free
through
a
simple
one-pot
method
examined
UV-resistant
performance
within
aluminum
complex
grease.
Findings
The
results
show
that
has
good
friction-reducing
anti-wear
which
is
attributed
adsorption
itself
generation
minor
amount
MoO
3
worn
surface
at
maximum
Hertzian
contact
pressure
0.6
Gpa.
also
absorption,
mainly
self-keto-enol
isomer
interconversion
from
special
structure
β-diketone.
Originality/value
work
demonstrates
feasible
way
develop
novel
multifunctional
organic
lubricating
materials.
Peer
review
peer
history
for
article
available
at:
https://publons.com/publon/10.1108/ILT-02-2025-0048/
