Raman Microspectroscopy Detection and Characterisation of Microplastics in Human Breastmilk

Polymers, Год журнала: 2022, Номер 14(13), С. 2700 - 2700

Опубликована: Июнь 30, 2022

The widespread use of plastics determines the inevitable human exposure to its by-products, including microplastics (MPs), which enter organism mainly by ingestion, inhalation, and dermal contact. Once internalised, MPs may pass across cell membranes translocate different body sites, triggering specific cellular mechanisms. Hence, potential health impairment caused internalisation accumulation is prime concern, as confirmed numerous studies reporting evident toxic effects in various animal models, marine organisms, lines. In this pilot single-centre observational prospective study, breastmilk samples collected from N. 34 women were analysed Raman Microspectroscopy, and, for first time, MP contamination was found 26 out samples. detected microparticles classified according their shape, colour, dimensions, chemical composition. most abundant composed polyethylene, polyvinyl chloride, polypropylene, with sizes ranging 2 12 µm. data statistically relation patients' (age, personal care products containing plastic compounds, consumption fish/shellfish, beverages, food packaging), but no significant relationship found, suggesting that ubiquitous presence makes inevitable.

Язык: Английский

---

Microplastics and Nanoplastics in Atheromas and Cardiovascular Events

New England Journal of Medicine, Год журнала: 2024, Номер 390(10), С. 900 - 910

Опубликована: Март 6, 2024

Microplastics and nanoplastics (MNPs) are emerging as a potential risk factor for cardiovascular disease in preclinical studies. Direct evidence that this extends to humans is lacking.

Язык: Английский

---

Microplastics detected in cirrhotic liver tissue

EBioMedicine, Год журнала: 2022, Номер 82, С. 104147 - 104147

Опубликована: Июль 11, 2022

The contamination of ecosystem compartments by microplastics (MPs) is an ubiquitous problem. MPs have been observed in mice tissues, and recently human blood, stool placenta. However, two aspects remain unclear: whether accumulate peripheral organs, specifically the liver, if liver cirrhosis favours this process. We aimed to examine tissue samples determine liver.This proof-of-concept case series, conducted Germany, Europe, analyzed 6 patients with 5 individuals without underlying disease. A total 17 (11 3 kidney spleen samples) were according final protocol. reliable method for detection MP particles from 4 30 µm was developed. Chemical digestion samples, staining Nile red, subsequent fluorescent microscopy Raman spectroscopy performed. Morphology, size composition polymers assessed.Considering limit detection, all disease tested negative MPs. In contrast, concentrations cirrhotic tissues positive showed significantly higher compared Six different microplastic ranging detected.This series assessed presence found six cirrhosis, but not those Future studies are needed evaluate hepatic accumulation represents a potential cause pathogenesis fibrosis, or consequence portal hypertension.No funding received conducting investigator driven study.

Язык: Английский

---

Microplastic sources, formation, toxicity and remediation: a review

Environmental Chemistry Letters, Год журнала: 2023, Номер 21(4), С. 2129 - 2169

Опубликована: Апрель 4, 2023

Abstract Microplastic pollution is becoming a major issue for human health due to the recent discovery of microplastics in most ecosystems. Here, we review sources, formation, occurrence, toxicity and remediation methods microplastics. We distinguish ocean-based land-based sources Microplastics have been found biological samples such as faeces, sputum, saliva, blood placenta. Cancer, intestinal, pulmonary, cardiovascular, infectious inflammatory diseases are induced or mediated by exposure during pregnancy maternal period also discussed. Remediation include coagulation, membrane bioreactors, sand filtration, adsorption, photocatalytic degradation, electrocoagulation magnetic separation. Control strategies comprise reducing plastic usage, behavioural change, using biodegradable plastics. Global production has risen dramatically over past 70 years reach 359 million tonnes. China world's top producer, contributing 17.5% global production, while Turkey generates waste Mediterranean region, at 144 tonnes per day. 75% marine waste, with responsible 80–90% pollution, account only 10–20%. induce toxic effects on humans animals, cytotoxicity, immune response, oxidative stress, barrier attributes, genotoxicity, even minimal dosages 10 μg/mL. Ingestion animals results alterations gastrointestinal tract physiology, system depression, differential gene expression, growth inhibition. Furthermore, bioaccumulation tissues aquatic organisms can adverse ecosystem, potential transmission birds. Changing individual behaviours governmental actions, implementing bans, taxes, pricing carrier bags, significantly reduced consumption 8–85% various countries worldwide. The microplastic minimisation approach follows an upside-down pyramid, starting prevention, followed reducing, reusing, recycling, recovering, ending disposal least preferable option.

Язык: Английский

---

The protein corona from nanomedicine to environmental science

Nature Reviews Materials, Год журнала: 2023, Номер 8(7), С. 422 - 438

Опубликована: Март 24, 2023

Язык: Английский

---

Detection of Various Microplastics in Patients Undergoing Cardiac Surgery

Environmental Science & Technology, Год журнала: 2023, Номер 57(30), С. 10911 - 10918

Опубликована: Июль 13, 2023

Microplastics have been detected in human stool, lungs, and placentas, which direct exposure to the external environment through various body cavities, including oral/anal cavity uterine/vaginal cavity. Crucial data on microplastic completely enclosed organs are still lacking. Herein, we used a laser infrared chemical imaging system scanning electron microscopy investigate whether microplastics exist heart its surrounding tissues. Microplastic specimens were collected from 15 cardiac surgery patients, 6 pericardia, epicardial adipose tissues, 11 pericardial 3 myocardia, 5 left atrial appendages, 7 pairs of pre- postoperative venous blood samples. not universally present all tissue samples, but nine types found across five with largest measuring 469 μm diameter. Nine also samples maximum diameter 184 μm, type distribution showed alterations following surgical procedure. Moreover, presence poly(methyl methacrylate) appendage, tissue, cannot be attributed accidental during surgery, providing evidence patients undergoing surgery. Further research is needed examine impact introduction potential effects internal health.

Язык: Английский

---

Current trends of unsustainable plastic production and micro(nano)plastic pollution

TrAC Trends in Analytical Chemistry, Год журнала: 2023, Номер 160, С. 116984 - 116984

Опубликована: Фев. 14, 2023

Unsustainable plastic production, use and mismanagement has resulted in increased global pollution subsequent degradation into micro(nano)plastics the environment threatening sustainability. Micro(nano)plastic is pervasive caused widespread ecological impacts globally, including greenhouse gas emissions, contributing to climate change. Although downstream strategies curb exist, they are ineffective face of current production waste generation which still outpacing existing regulations. Thus, international community recognized a more holistic approach required reduce micro(nano)plastic pollution. This critical review highlights studies showing that unsustainable increasing all environmental compartments, yet few have documented successful prevention or removal techniques. offers constructive criticism some help advance ambitious reduction targets for transition towards sustainable plastics future.

Язык: Английский

---

Identification of microplastics in human placenta using laser direct infrared spectroscopy

The Science of The Total Environment, Год журнала: 2022, Номер 856, С. 159060 - 159060

Опубликована: Сен. 26, 2022

Язык: Английский

---

Microplastic diagnostics in humans: “The 3Ps” Progress, problems, and prospects

The Science of The Total Environment, Год журнала: 2022, Номер 856, С. 159164 - 159164

Опубликована: Окт. 3, 2022

Язык: Английский

---

Absorption, distribution, metabolism, excretion and toxicity of microplastics in the human body and health implications

Journal of Hazardous Materials, Год журнала: 2022, Номер 437, С. 129361 - 129361

Опубликована: Июнь 16, 2022

Язык: Английский

---