The histopathological and functional consequences of microplastic exposure DOI Creative Commons

Yujeong Lee,

Min Kyung Sung, Soo‐Eun Sung

и другие.

Deleted Journal, Год журнала: 2025, Номер 7(1)

Опубликована: Янв. 11, 2025

As the production, usage, and disposal of plastics increase, microplastics generated—plastic particles smaller than 5 mm—increases, exacerbating environmental pollution. In turn, various organisms become increasingly exposed to contaminated environments, potentially affecting humans through food chain. Crucial findings from in vivo experiments indicate histopathological changes caused by impact morphology physiological function organisms. This study describes induced across circulatory, nervous, digestive, respiratory, reproductive systems explains associated functional alterations. Except nervous system, main morphological involve degenerative throughout body, such as apoptosis, inflammation, fibrosis. Most were inflammatory responses microplastics, leading fibrosis subsequent impairments. Various studies confirm that stimulate cells, increased reactive oxygen species cell death. Consequently, these impair related systemic functions. review highlights fundamental organs cells due discusses limitations involving showing no changes.

Язык: Английский

The potential impacts of micro-and-nano plastics on various organ systems in humans DOI Creative Commons
Nurshad Ali,

Jenny Katsouli,

Emma L. Marczylo

и другие.

EBioMedicine, Год журнала: 2023, Номер 99, С. 104901 - 104901

Опубликована: Дек. 6, 2023

Humans are exposed to micro-and-nano plastics (MNPs) through various routes, but the adverse health effects of MNPs on different organ systems not yet fully understood. This review aims provide an overview potential impacts and identify knowledge gaps in current research. The summarized results suggest that exposure can lead oxidative stress, inflammation, immune dysfunction, altered biochemical energy metabolism, impaired cell proliferation, disrupted microbial metabolic pathways, abnormal development, carcinogenicity. There is limited human data MNPs, despite evidence from animal cellular studies. Most published research has focused specific types assess their toxicity, while other plastic particles commonly found environment remain unstudied. Future studies should investigate by considering realistic concentrations, dose-dependent effects, individual susceptibility, confounding factors.

Язык: Английский

Процитировано

132
Tissue accumulation of microplastics and potential health risks in human DOI
Long Zhu, Yulin Kang,

Mindong Ma

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 915, С. 170004 - 170004

Опубликована: Янв. 21, 2024

Язык: Английский

Процитировано

85
Microplastics in three types of human arteries detected by pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) DOI
Sheng Liu, Chenyang Wang, Yunxiao Yang

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 469, С. 133855 - 133855

Опубликована: Фев. 21, 2024

Язык: Английский

Процитировано

78
MicroRaman spectroscopy detects the presence of microplastics in human urine and kidney tissue DOI Creative Commons
Sara Massardo, Daniela Verzola, Stefano Alberti

и другие.

Environment International, Год журнала: 2024, Номер 184, С. 108444 - 108444

Опубликована: Янв. 19, 2024

There is a growing concern within the medical community about potential burden of microplastics on human organs and tissues. In this study, we investigated by microRaman spectroscopy presence in kidneys urine. Moreover, an open-access software was developed validated for project, which enabled comparison between spectra self-created spectral database, thus enhancing ability to characterize polymers pigments biological matrices. Healthy portions ten obtained from nephrectomies, as well urine samples healthy donors were analyzed: 26 particles both kidney identified, with sizes ranging 3 13 μm 1 29 kidneys. The most frequently determined are polyethylene polystyrene, while common hematite Cu-phthalocyanine. This preclinical study proves renal tissues confirms their urine, providing first evidence deposition humans.

Язык: Английский

Процитировано

63
The “Microplastome” – A Holistic Perspective to Capture the Real-World Ecology of Microplastics DOI Creative Commons
Changchao Li, Xinyu Li, Michael S. Bank

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер unknown

Опубликована: Фев. 8, 2024

Microplastic pollution, an emerging pollution issue, has become a significant environmental concern globally due to its ubiquitous, persistent, complex, toxic, and ever-increasing nature. As multifaceted diverse suite of small plastic particles with different physicochemical properties associated matters such as absorbed chemicals microbes, future research on microplastics will need comprehensively consider their multidimensional attributes. Here, we introduce novel, conceptual framework the "microplastome", defined entirety various (<5 mm), found within sample overall toxicological impacts. novel concept, this paper aims emphasize call for collective quantification characterization more holistic understanding regarding differences, connections, effects in biotic abiotic ecosystem compartments. Deriving from lens, present our insights prospective trajectories characterization, risk assessment, source apportionment microplastics. We hope new paradigm can guide propel microplastic toward era contribute informed strategy combating important issue.

Язык: Английский

Процитировано

52
Interaction of microplastics with heavy metals in soil: Mechanisms, influencing factors and biological effects DOI

Baiyan Liu,

Shuling Zhao, Tianyi Qiu

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 918, С. 170281 - 170281

Опубликована: Янв. 24, 2024

Язык: Английский

Процитировано

45
Micro(nano)plastics in the Human Body: Sources, Occurrences, Fates, and Health Risks DOI
Penghui Li,

Jingfu Liu

Environmental Science & Technology, Год журнала: 2024, Номер unknown

Опубликована: Фев. 5, 2024

The increasing global attention on micro(nano)plastics (MNPs) is a result of their ubiquity in the water, air, soil, and biosphere, exposing humans to MNPs daily basis threatening human health. However, crucial data body, including sources, occurrences, behaviors, health risks, are limited, which greatly impedes any systematic assessment impact body. To further understand effects we must identify existing knowledge gaps that need be immediately addressed provide potential solutions these issues. Herein, examined current literature behaviors body as well risks. Furthermore, identified key resolved comprehensively assess Additionally, complexity lack efficient analytical methods main barriers impeding investigations necessitating development standard unified method. Finally, highlighted for interdisciplinary studies from environmental, biological, medical, chemical, computer, material scientists fill drive research. Considering inevitability occurrence exposure MNPs, more urgently required enhance our understanding negative

Язык: Английский

Процитировано

39
Features, Potential Invasion Pathways, and Reproductive Health Risks of Microplastics Detected in Human Uterus DOI
Xunsi Qin,

Mingjun Cao,

Tianliu Peng

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер 58(24), С. 10482 - 10493

Опубликована: Июнь 3, 2024

Microplastics (MPs) are ubiquitous in global ecosystems and may pose a potential risk to human health. However, critical information on MP exposure female reproductive health is still lacking. In this study, we characterized MPs endometrium investigated their size-dependent entry mode as well toxicity. Endometrial tissues of 22 patients were examined, revealing that was contaminated with MPs, mainly polyamide (PA), polyurethane (PU), polyethylene terephthalate (PET), polypropylene (PP), polystyrene (PS), (PE), ranging from 2–200 μm size. Experiments conducted mice demonstrated the invasion uterus by modulated either through diet–blood circulation (micrometer-sized particles) or via vagina–uterine lacuna (larger particles reaching size 100 μm. Intravenous resulted reduced fertility abnormal sex ratio mouse offspring (P < 0.05). After 3.5 months intragastric exposure, there significant inflammatory response 0.05), confirmed embryo transfer uterine factor leading decreased fertility. Furthermore, endometrial organoids cultured vitro exhibited significantly apoptotic responses disrupted growth patterns 0.01). These findings raise concerns regarding contamination its effects

Язык: Английский

Процитировано

38
A comprehensive review on the source, ingestion route, attachment and toxicity of microplastics/nanoplastics in human systems DOI
Yining Zhu,

Ruijie Che,

Xinyan Zong

и другие.

Journal of Environmental Management, Год журнала: 2024, Номер 352, С. 120039 - 120039

Опубликована: Янв. 13, 2024

Язык: Английский

Процитировано

32
Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites DOI Creative Commons
Tingting Wang,

Zhiheng Yi,

Xiaoqiang Liu

и другие.

EBioMedicine, Год журнала: 2024, Номер 103, С. 105118 - 105118

Опубликована: Апрель 13, 2024

BackgroundMicroplastic (MP) pollution has emerged as a significant environmental concern worldwide. While extensive research focused on their presence in marine organisms and ecosystems, potential impact human health, particularly the circulatory system, remains understudied. This project aimed to identify quantify mass concentrations, polymer types, physical properties of MPs thrombi surgically retrieved from both arterial venous systems at three anatomically distinct sites, namely, cerebral arteries brain, coronary heart, deep veins lower extremities. Furthermore, this study investigate association between levels disease severity.MethodsThrombus samples were collected 30 patients who underwent thrombectomy procedures due ischaemic stroke (IS), myocardial infarction (MI), or vein thrombosis (DVT). Pyrolysis–gas chromatography spectrometry (Py-GC/MS) was employed concentrations MPs. Laser direct infrared (LDIR) spectroscopy scanning electron microscopy (SEM) used analyse Demographic clinical information also examined. A rigorous quality control system eliminate contamination.FindingsMPs detected by Py-GC/MS 80% (24/30) obtained with IS, MI, DVT, median 61.75 μg/g, 141.80 69.62 respectively. Among 10 target types MP polymers, polyamide 66 (PA66), polyvinyl chloride (PVC), polyethylene (PE) identified. Further analyses suggested that higher may be associated greater severity (adjusted β = 7.72, 95% CI: 2.01–13.43, p < 0.05). The level D-dimer MP-detected group significantly than MP-undetected (8.3 ± 1.5 μg/L vs 6.6 0.5 μg/L, 0.001). Additionally, LDIR analysis showed PE dominant among 15 identified MPs, accounting for 53.6% all mean diameter 35.6 μm. shapes polymers using SEM found heterogeneous.InterpretationThis presents qualitative quantitative evidence thrombotic diseases through use multimodal detection methods. Higher increased severity. Future larger sample size is urgently needed sources exposure validate observed trends study.FundingThis funded SUMC Scientific Research Initiation Grant (SRIG, No. 009-510858038), Postdoctoral (No. 202205230031-3), 2020 Li Ka Shing Foundation Cross-Disciplinary 2020LKSFG02C).

Язык: Английский

Процитировано

29