Luteolin enhanced antioxidant capability and induced pyroptosis through NF-κB/NLRP3/Caspase-1 in splenic lymphocytes exposure to ammonia

The Science of The Total Environment, Год журнала: 2024, Номер 919, С. 170699 - 170699

Опубликована: Фев. 5, 2024

Язык: Английский

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Neurotoxic effects of 2-ethylhexyl diphenyl phosphate exposure on zebrafish larvae: Insight into inflammation-driven changes in early motor behavior

The Science of The Total Environment, Год журнала: 2024, Номер 915, С. 170131 - 170131

Опубликована: Янв. 20, 2024

Язык: Английский

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Chlorinated Organophosphate Flame Retardants Impair the Lung Function via the IL-6/JAK/STAT Signaling Pathway

Environmental Science & Technology, Год журнала: 2022, Номер 56(24), С. 17858 - 17869

Опубликована: Дек. 8, 2022

Toxicological studies have revealed the adverse impacts of organophosphate flame retardants (OPFRs) on respiratory system, while there is a lack epidemiological evidence, and information for risk assessment remains insufficient. Herein, we investigated associations urinary metabolites OPFRs with lung function in 987 adults participating U.S. National Health Nutrition Examination Survey 2011–2012. The elevation three primary chlorinated [bis(1,3-dichloro-2-propyl) phosphate (BDCIPP), bis(2-chloroethyl) (BCEP), bis(1-chloro-2-propyl) (BCIPP)] was related to pulmonary dysfunction sample-weighted regression model. Each one-unit increase log-transformed levels BDCIPP BCEP 91.52 79.34 mL reductions forced vital capacity (FVC). BCIPP correlated 130.86, 153.56, 302.26, 148.24 expiratory volume 1st second (FEV1), FVC, peak flow rate (PEF), at 25-75% FVC (FEF25–75%), respectively. Then, an outcome pathway (AOP) framework constructed using Comparative Toxicogenomics Database, Toxicity Forecaster, GeneCards database. Based weight BDCIPP, BCEP, BCIPP, their parent compounds (TDCIPP, TCEP, TCIPP) may affect IL-6/Janus kinase/signal transducer activator transcription (JAK/STAT) pathway, induce airway remodeling, impair function. Additionally, tobacco smoke exposure modify effects (Pint < 0.05) IL-6-mediated AOP. These results suggested that were associated via IL-6/JAK/STAT pathway.

Язык: Английский

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Human airway organoids as 3D in vitro models for a toxicity assessment of emerging inhaled pollutants: Tire wear particles

Frontiers in Bioengineering and Biotechnology, Год журнала: 2023, Номер 10

Опубликована: Янв. 6, 2023

Three-dimensional (3D) structured organoids have become increasingly promising and effective in vitro models, there is an urgent need for reliable models to assess health effects of inhaled pollutants on the human airway. In our study, we conducted a toxicity assessment airway (hAOs) tire wear particles (TWPs) as emerging pollutant. We induced primary bronchial epithelial cells (HBECs) generated organoids, which recapitulated key features including basal cells, ciliated goblet club cells. TWPs from wearing treads were considered major source road traffic-derived non-exhaust particles, but their effect lungs poorly understood. used toxicology exposure inhibitory growth was observed. significant cell apoptosis oxidative stress dose-dependent manner. From qPCR analysis, significantly up-regulated expression pf genes involved inflammation response. Additionally, reduced SCGB1A1 gene associated with function KRT5 related conclusion, this first study using toxicological TWPs, findings revealed that provide evaluation model potentially affecting lungs.

Язык: Английский

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Investigation of alkyl, aryl, and chlorinated OPFRs in sediments from estuarine systems: Seasonal variation, spatial distribution and ecological risks assessment

Environmental Research, Год журнала: 2024, Номер 250, С. 118465 - 118465

Опубликована: Фев. 15, 2024

Estuaries in South Africa are very important for biodiversity conservation and serve as focal points leisure tourism activities. The organophosphate flame retardants (OPFRs) levels these aquatic systems haven't been documented any studies of yet. Due to the negative effects persistent organic pollutants African estuaries, we examined occurrence eight OPFRs sediments two estuaries by studying their spatiotemporal distribution, season variation, ecological risks. Sundays Estuary (SDE), a semi-urbanized agricultural surrounding system, recorded an ∑

Язык: Английский

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Indoor Air Pollution and Airway Health

Journal of Allergy and Clinical Immunology, Год журнала: 2024, Номер 154(4), С. 835 - 846

Опубликована: Авг. 24, 2024

Because of the disproportionate amount time that people spend indoors and complexities air pollutant exposures found there, indoor pollution is a growing concern for airway health. Both infiltration outdoor into space sources (such as smoke from tobacco products, cooking or heating practices combustion associated fuels, household materials) contribute to unique exposure mixtures. Although there substantial literature on chemistry pollution, research focused health effects only beginning emerge remains an important area need protect public We provide review emerging spanning past 3 years relating health, with specific focus impact either individual common lower airways. Factors defining susceptibility and/or vulnerability are reviewed consideration priority populations modifiable risk factors may be targeted advance equity.

Язык: Английский

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A comprehensive and quantitative comparison of organophosphate esters: Characteristics, applications, environmental occurrence, toxicity, and health risks

Critical Reviews in Environmental Science and Technology, Год журнала: 2024, Номер 55(5), С. 310 - 333

Опубликована: Сен. 28, 2024

Язык: Английский

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Exposure to organophosphate flame retardants and plasticizers is positively associated with wheeze and FeNO and eosinophil levels among school-aged children: The Hokkaido study

Environment International, Год журнала: 2023, Номер 181, С. 108278 - 108278

Опубликована: Окт. 20, 2023

Exposure to organophosphate flame retardants and plasticizers (PFRs) increases the risk of asthma allergies. However, little is known about its association with type 2 inflammation (T2) biomarkers used in management The study investigated associations among urinary PFR metabolite concentrations, allergic symptoms, T2 biomarkers. data samples were collected between 2017 2020, including school children (n = 427) aged 9-12 years living Sapporo City, Japan, participants "The Hokkaido Study on Environment Children's Health." Thirteen metabolites measured by LC-MS/MS. Allergic symptoms assessed using International Asthma Allergies Childhood questionnaire. For biomarkers, peripheral blood eosinophil counts, fraction exhaled nitric oxide level (FeNO), serum total immunoglobulin E measured. Multiple logistic regression analysis, quantile-based g-computation (qg-computation), Bayesian kernel machine (BKMR) examine health outcomes individual PFRs mixtures. highest concentration was Σtris(1-chloro-isopropyl) phosphates (ΣTCIPP) (Median:1.20 nmol/L). Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) significantly associated a high odds ratio (OR, 95%CI:1.36, 1.07-1.72) for wheeze. TDCIPP 95%CI:1.19, 1.02-1.38), Σtriphenyl (ΣTPHP) 95%CI:1.81, 1.40-2.37), Σtris(2-butoxyethyl) (ΣTBOEP) 95%:1.40, 1.13-1.74) increased FeNO (≥35 ppb). ΣTPHP 95%CI:1.44, 1.15-1.83) counts (≥300/μL). mixtures, one-quartile increase all 95%CI:1.48, 1.18-1.86) ppb) qg-computation model. mixture positively (≥300/μL) BKMR models. These results may suggest that exposure probability asthma, allergies, inflammation.

Язык: Английский

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The relationship of organophosphate flame retardants with hyperuricemia and gout via the inflammatory response: An integrated approach

The Science of The Total Environment, Год журнала: 2023, Номер 908, С. 168169 - 168169

Опубликована: Ноя. 1, 2023

Язык: Английский

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Do the same chlorinated organophosphorus flame retardants that cause cytotoxicity and DNA damage share the same pathway?

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 273, С. 116158 - 116158

Опубликована: Фев. 27, 2024

Organophosphorus flame retardants (OPFRs) have been frequently detected with relatively high concentrations in various environmental media and are considered emerging pollutants. However, their biological effect underlying mechanism is still unclear, whether chlorinated OPFRs (Cl-OPFRs) cause adverse outcomes the same molecular initial events or share key (KEs) remains unknown. In this study, vitro bioassays were conducted to analyze cytotoxicity, mitochondrial impairment, DNA damage mechanisms of two Cl-OPFRs. The results showed that these Cl-OPFRs, which similar structures, induced severe cellular damages via different mechanisms. Both tris(2-chloroethyl) phosphate (TCEP) tris(1-chloro-2-propyl) (TCPP) oxidative stress-mediated impairment damage, as shown by overproduction intracellular reactive oxygen species (ROS) superoxide. Furthermore, caused TCPP resulted p53/p21-mediated cell cycle arrest, evidenced flow cytometry real-time PCR. At levels, increased sub-G1 apoptotic peak upregulated p53/Bax apoptosis pathway, possibly associated its stronger cytotoxicity. Although structurally TCPP, TCEP did not induce KEs. These provide insight into toxicity Cl-OPFRs structures but mechanisms, great significance for constructing outcome pathways determining intermediate

Язык: Английский

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