Biology of Reproduction,
Год журнала:
2023,
Номер
110(1), С. 211 - 218
Опубликована: Сен. 19, 2023
Abstract
Maternal
exposure
to
microplastics
and
nanoplastics
has
been
shown
result
in
fetal
growth
restriction
mice.
In
this
study,
we
investigated
the
placental
hemodynamic
responses
plastics
mice
using
high-frequency
ultrasound.
Healthy,
pregnant
CD-1
dams
were
given
either
106
ng/L
of
5
μm
polystyrene
or
50
nm
drinking
water
throughout
gestation
compared
with
controls.
both
resulted
evidence
dysfunction
that
was
highly
dependent
on
particle
size.
The
umbilical
artery
blood
flow
increased
by
48%
microplastic-exposed
group
decreased
25%
nanoplastic-exposed
controls
(p
<
0.05).
microplastic-
fetuses
showed
a
significant
decrease
middle
cerebral
pulsatility
index
10%
13%,
respectively,
0.05),
indicating
vasodilation
circulation,
adaptation
is
part
brain
sparing
response
preserve
oxygen
delivery.
Hemodynamic
markers
hypoxia
more
pronounced
exposed
nanoplastics,
suggesting
nanoplastic
during
human
pregnancy
potential
disrupt
development,
which
turn
may
cause
suboptimal
neurodevelopmental
outcomes.
Nanoparticles
(NPs)
have
become
one
of
the
most
popular
objects
scientific
study
during
past
decades.
However,
despite
wealth
reports,
still
there
is
a
gap,
particularly
in
health
toxicology
studies,
underlying
mechanisms,
and
related
evaluation
models
to
deeply
understanding
NPs
risk
effects.
In
this
review,
we
first
present
comprehensive
landscape
applications
on
health,
especially
addressing
role
medical
diagnosis,
therapy.
Then,
toxicity
systems
introduced.
We
describe
detail
effects
various
systems,
including
respiratory,
nervous,
endocrine,
immune,
reproductive
carcinogenicity
NPs.
Furthermore,
unravels
mechanisms
ROS
accumulation,
mitochondrial
damage,
inflammatory
reaction,
apoptosis,
DNA
cell
cycle,
epigenetic
regulation.
addition,
classical
such
as
lines
mice
emerging
3D
organoids
used
for
evaluating
or
are
both
Overall,
review
presents
critical
summary
state
NPs,
giving
readers
more
better
remedy
key
gaps
knowledge
techniques.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2022,
Номер
64(11), С. 3502 - 3521
Опубликована: Окт. 17, 2022
Plastic
waste
pollution
is
one
of
the
biggest
problems
in
world
today.
The
amount
plastic
environment
continues
to
increase,
and
human
exposure
microplastic
(MP)
has
become
a
reality.
This
subject
attracted
attention
whole
world.
MP
problem
also
been
noticed
by
scientific
community.
term
mostly
used
define
synthetic
material
with
high
polymer
content
that
can
have
size
range
from
0.1
5000
µm.
paper
aims
characterize
routes
MP,
its
sources,
identify
food
types
contaminated
plastics.
review
addresses
current
state
knowledge
on
this
type
particles,
particular
emphasis
their
influence
health.
Adverse
effects
depend
sources
exposure.
most
common
route
believed
be
gastrointestinal
tract.
Sources
include
fish,
shellfish,
water
as
well
tea,
beer,
wine,
energy
drinks,
soft
milk,
salt,
sugar,
honey,
poultry
meat,
fruits,
vegetables.
Studies
shown
particles
PET,
PE,
PP,
PS,
PVC,
PA,
PC
are
frequently
found
food.
Particle and Fibre Toxicology,
Год журнала:
2023,
Номер
20(1)
Опубликована: Ноя. 22, 2023
Microplastics
and
nanoplastics
(MNPs)
are
emerging
environmental
contaminants
detected
in
human
samples,
have
raised
concerns
regarding
their
potential
risks
to
health,
particularly
neurotoxicity.
This
study
aimed
investigate
the
deleterious
effects
of
polystyrene
(PS-NPs,
50
nm)
understand
mechanisms
inducing
Parkinson's
disease
(PD)-like
neurodegeneration,
along
with
exploring
preventive
strategies.
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 4, 2024
Plastics
found
in
our
everyday
environment
are
becoming
an
increasing
concern
for
individual
and
population-level
health,
the
extent
of
exposure
potential
toxic
effects
these
contaminants
on
numerous
human
organ
systems
clear.
Microplastics
(MPs),
tiny
plastic
particles,
appear
to
have
many
same
biological
as
their
precursors
compounded
effect
accumulation
different
organs.
Recently,
microplastic
was
observed
placenta,
raising
important
questions
related
health
pregnancies
offspring.
These
concerns
particularly
heightened
considering
developmental
origins
disease
(DOHaD)
framework,
which
postulates
that
utero
can
programme
lifelong
The
current
review
examines
state
knowledge
this
topic
highlights
avenues
future
investigation.
Particle and Fibre Toxicology,
Год журнала:
2024,
Номер
21(1)
Опубликована: Март 7, 2024
Abstract
Background
With
rapid
increase
in
the
global
use
of
various
plastics,
microplastics
(MPs)
and
nanoplastics
(NPs)
pollution
their
adverse
health
effects
have
attracted
attention.
MPs
been
detected
out
human
body
both
NPs
showed
female
reproductive
toxicological
animal
models.
Miscarriage
(abnormal
early
embryo
loss),
accounting
for
15-25%
pregnant
women
worldwide,
greatly
harms
reproduction.
However,
on
miscarriage
never
explored.
Results
In
this
study,
we
identified
that
polystyrene
(PS)
plastics
particles
were
present
villous
tissues.
Their
levels
higher
tissues
unexplained
recurrent
(RM)
patients
vs.
healthy
control
(HC)
group.
Furthermore,
mouse
assays
further
confirmed
exposure
to
(PS-NPs,
50
nm
diameter,
or
100
mg/kg)
indeed
induced
miscarriage.
mechanism,
PS-NPs
(50,
100,
150,
200
µg/mL)
increased
oxidative
stress,
decreased
mitochondrial
membrane
potential,
apoptosis
trophoblast
cells
by
activating
Bcl-2/Cleaved-caspase-2/Cleaved-caspase-3
signaling
through
pathway.
The
alteration
was
consistent
placental
PS-NPs-exposed
model
RM
patients.
Supplement
with
Bcl-2
could
efficiently
suppress
reduce
alleviate
model.
Conclusions
Exposure
activated
Bcl-2/Cleaved-caspase-2/Cleaved-caspase-3,
leading
excessive
mice
tissues,
inducing
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