Applied Sciences,
Год журнала:
2024,
Номер
14(16), С. 7280 - 7280
Опубликована: Авг. 19, 2024
Nanoplastics
(NPs)
represent
an
escalating
hazard
to
both
humans
and
the
ecosystem
due
their
pervasive
presence.
This
review
delves
into
(i)
widespread
occurrence
of
NPs
across
different
environmental
matrices,
including
food;
(ii)
routes
estimates
for
human
exposure;
(iii)
mechanisms
blood–brain
barrier
(BBB)
crossing;
(iv)
implications
health,
with
a
specific
focus
on
molecular
features
associated
neurotoxicity
neurodegenerative
processes.
The
impact
central
nervous
system,
ability
cross
BBB
underpinning
mechanisms,
potential
initiate
by
fostering
β-amyloid
aggregation,
interactions
metallo-enzymes
(such
as
superoxide
dismutase)
are
elucidated.
analysis
transcriptomics
epigenomic
results,
microRNA
dysregulation,
unveil
how
could
contribute
neurological
disorders.
need
considering
overlaps
among
diverse
pathogenetic
when
probing
effects
is
discussed.
Additional
urgent
needs
development
reliable
in
vitro
models
studies
able
mimic
complexity
system
exposure
such
more
environmentally
relevant
NPs.
Finally,
extremely
sensitive
detection
methodologies
quantify
biological
matrices
pressing
priority.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(29)
Опубликована: Авг. 24, 2023
Nanoplastics
(NPs)
may
pass
through
the
blood-brain
barrier,
giving
rise
to
serious
concerns
about
their
potential
toxicity
brain.
In
this
study,
effects
of
NPs
exposure
on
learning
and
memory,
primary
cognitive
functions
brain,
are
assessed
in
zebrafish
with
classic
T-maze
exploration
tasks.
Additionally,
reveal
affecting
mechanisms,
impacts
brain
aging,
oxidative
damage,
energy
provision,
cell
cycle
evaluated.
The
results
demonstrate
that
NP-exposed
takes
significantly
longer
for
first
entry
spends
markedly
less
time
reward
zone
task,
indicating
occurrence
memory
deficits.
Moreover,
higher
levels
aging
markers
(β-galactosidase
lipofuscin)
detected
brains
fish.
Along
accumulation
reactive
free
radicals,
suffer
significant
damage.
Furthermore,
lower
Adenosine
triphosphate
(ATP)
cyclin-dependent
kinase
2
p53
observed
zebrafish,
suggesting
also
a
shortage
supply
an
arrestment
cycle.
These
findings
suggest
pose
severe
threat
health,
which
deserves
closer
attention.
Environmental Science and Ecotechnology,
Год журнала:
2024,
Номер
21, С. 100428 - 100428
Опубликована: Май 3, 2024
Micro/nanoplastics
(MNPs)
are
detected
in
human
liver,
and
pose
significant
risks
to
health.
Oral
exposure
MNPs
derived
from
non-biodegradable
plastics
can
induce
toxicity
mouse
liver.
Similarly,
nasal
cause
airway
dysbiosis
mice.
However,
the
hepatotoxicity
induced
by
foodborne
airborne
biodegradable
remains
poorly
understood.
Here
we
show
hepatotoxic
effects
of
polylactic
acid
(PLA)
through
multi-omics
analysis
various
biological
samples
mice,
including
gut,
fecal,
nasal,
lung,
blood
samples.
Our
results
that
both
PLA
compromise
liver
function,
disrupt
serum
antioxidant
activity,
pathology.
Specifically,
lead
gut
microbial
dysbiosis,
metabolic
alterations
serum,
transcriptomic
changes.
Airborne
affect
lung
microbiota,
alter
metabolites,
transcriptomics.
The
Lachnospiraceae_NK4A136_group
is
a
potential
biomarker
for
MNP
exposure,
while
unclassified
Journal of Applied Toxicology,
Год журнала:
2024,
Номер
44(11), С. 1657 - 1678
Опубликована: Март 17, 2024
Abstract
Plastic
waste
comprises
polymers
of
different
chemicals
that
disintegrate
into
nanoplastic
particles
(NPLs)
1–100‐nm
size,
thereby
littering
the
environment
and
posing
a
threat
to
wildlife
human
health.
Research
on
NPL
contamination
has
up
now
focused
ecotoxicology
effects
pollution
rather
than
health
risks.
This
review
aimed
speculate
about
possible
properties
carcinogenic
neurotoxic
as
pollutants.
Given
their
low‐dimensional
size
high
surface
ratio,
NPLs
can
easily
penetrate
biological
membranes
cause
functional
structural
damage
in
cells.
Once
inside
cell,
interrupt
autophagy
flux
cellular
debris,
alter
proteostasis,
provoke
mitochondrial
dysfunctions,
induce
endoplasmic
reticulum
stress.
Harmful
metabolic
processes
induced
by
include
oxidative
stress
(OS),
ROS
generation,
pro‐inflammatory
reactions.
Depending
cell
cycle
status,
may
direct
DNA
damage,
tumorigenesis,
lately
carcinogenesis
tissues
with
self‐renewal
capabilities
like
epithelia.
In
cells
able
live
longest
neurons,
could
trigger
neurodegeneration
promoting
toxic
proteinaceous
aggregates,
OS,
chronic
inflammation.
genotoxicity
neurotoxicity
are
discussed
based
gathered
evidence,
when
available,
within
context
intracellular
uptake
these
newcomer
nanoparticles.
summary,
this
explains
how
risk
evaluation
for
benefit
from
accurately
monitoring
toxicokinetics
toxicodynamics
at
resolution
level.
