The possible impacts of nano and microplastics on human health: lessons from experimental models across multiple organs DOI

Bernardo Lannes Monteiro Fontes,

Lorena Cristina de Souza e Souza,

Ana Paula Santos da Silva de Oliveira

и другие.

Journal of Toxicology and Environmental Health Part B, Год журнала: 2024, Номер 27(4), С. 153 - 187

Опубликована: Март 22, 2024

The widespread production and use of plastics have resulted in accumulation plastic debris the environment, gradually breaking down into smaller particles over time. Nano-plastics (NPs) microplastics (MPs), defined as than 100 nanometers 5 millimeters, respectively, raise concerns due to their ability enter human body through various pathways including ingestion, inhalation, skin contact. Various investigators demonstrated that these may produce physical chemical damage cells, tissues, organs, disrupting cellular processes, triggering inflammation oxidative stress, impacting hormone neurotransmitter balance. In addition, micro- nano-plastics (MNPLs) carry toxic chemicals pathogens, exacerbating adverse effects on health. magnitude nature are not yet fully understood, requiring further research for a comprehensive risk assessment. Nevertheless, evidence available suggests environment potential uptake causes concern. Urgent measures reduce pollution limit exposure MNPLs necessary safeguard health environment. this review, current knowledge regarding influence is summarized, toxicity mechanisms, pathways, outcomes across multiple organs. critical need additional also emphasized comprehensively assess risks posed by degradation inform strategies addressing emerging environmental challenge. Finally, new directions proposed evaluation gene regulation associated with exposure.

Язык: Английский

The potential of micro- and nanoplastics to exacerbate the health impacts and global burden of non-communicable diseases DOI Creative Commons
Stefan Krause, Valérie Ouellet, Deonie Allen

и другие.

Cell Reports Medicine, Год журнала: 2024, Номер 5(6), С. 101581 - 101581

Опубликована: Май 22, 2024

Non-communicable diseases (NCD) constitute one of the highest burdens disease globally and are associated with inflammatory responses in target organs. There is increasing evidence significant human exposure to micro- nanoplastics (MnPs). This review environmental MnP health impacts indicates that particles, directly indirectly through their leachates, may exacerbate inflammation. Meanwhile, persistent inflammation NCDs gastrointestinal respiratory systems potentially increases uptake, thus influencing access distal Consequently, a future increase augments risk severity NCDs. critical need for an integrated one-health approach research assessing drivers bidirectional links Assessing these risks requires interdisciplinary efforts identify link organismal uptake studies impacted mechanisms outcomes.

Язык: Английский

Процитировано

28
The alarming link between environmental microplastics and health hazards with special emphasis on cancer DOI

Sohini Goswami,

Satadal Adhikary, Suchandra Bhattacharya

и другие.

Life Sciences, Год журнала: 2024, Номер 355, С. 122937 - 122937

Опубликована: Авг. 3, 2024

Язык: Английский

Процитировано

23
Micro/nano-plastics impacts in cardiovascular systems across species DOI
Ji Liang, Feng Ji,

Anisah Lee Binti Abdullah

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 942, С. 173770 - 173770

Опубликована: Июнь 7, 2024

Язык: Английский

Процитировано

17
Microplastics in the bloodstream can induce cerebral thrombosis by causing cell obstruction and lead to neurobehavioral abnormalities DOI Creative Commons
Haipeng Huang, Jiaqi Hou,

Mingxiao Li

и другие.

Science Advances, Год журнала: 2025, Номер 11(4)

Опубликована: Янв. 22, 2025

Human health is being threatened by environmental microplastic (MP) pollution. MPs were detected in the bloodstream and multiple tissues of humans, disrupting regular physiological processes organs. Nanoscale plastics can breach blood-brain barrier, leading to neurotoxic effects. How cause brain functional irregularities remains unclear. This work uses high-depth imaging techniques investigate within vivo. We show that circulating are phagocytosed lead these cells obstruction capillaries cortex. These blockages as thrombus formation reduced blood flow neurological abnormalities mice. Our data reveal a mechanism which disrupt tissue function indirectly through regulation cell interference with local circulation, rather than direct penetration. revelation offers lens comprehend toxicological implications invade bloodstream.

Язык: Английский

Процитировано

6
Quantification of microplastics released from plastic food containers during rinsing and migration by pyrolysis-gas chromatography/mass spectrometry DOI

Zhongping Huang,

Junhao Zhang,

Baoquan Pan

и другие.

Food Chemistry, Год журнала: 2025, Номер 472, С. 142934 - 142934

Опубликована: Янв. 17, 2025

Язык: Английский

Процитировано

2
Polystyrene nanoplastic exposure induces excessive mitophagy by activating AMPK/ULK1 pathway in differentiated SH-SY5Y cells and dopaminergic neurons in vivo DOI Creative Commons

Yuji Huang,

Boxuan Liang,

Zhiming Li

и другие.

Particle and Fibre Toxicology, Год журнала: 2023, Номер 20(1)

Опубликована: Ноя. 22, 2023

Microplastics and nanoplastics (MNPs) are emerging environmental contaminants detected in human samples, have raised concerns regarding their potential risks to health, particularly neurotoxicity. This study aimed investigate the deleterious effects of polystyrene (PS-NPs, 50 nm) understand mechanisms inducing Parkinson's disease (PD)-like neurodegeneration, along with exploring preventive strategies.

Язык: Английский

Процитировано

41
Nanoplastics induces oxidative stress and triggers lysosome-associated immune-defensive cell death in the earthworm Eisenia fetida DOI Creative Commons
Yanfei Zhou, Gang He, Hao Jiang

и другие.

Environment International, Год журнала: 2023, Номер 174, С. 107899 - 107899

Опубликована: Март 27, 2023

Nanoplastics (NPs) are increasingly perceived as an emerging threat to terrestrial environments, but the adverse impacts of NPs on soil fauna and mechanisms behind these negative outcomes remain elusive. Here, a risk assessment was conducted model organism (earthworm) from tissue cell. Using palladium-doped polystyrene NPs, we quantitatively measured nanoplastic accumulation in earthworm investigated its toxic effects by combining physiological with RNA-Seq transcriptomic analyses. After 42-day exposure, accumulated up 15.9 143.3 mg kg-1 for low (0.3 kg-1) high (3 dose groups, respectively. retention led decrease antioxidant enzyme activity reactive oxygen species (O2- H2O2), which reduced growth rate 21.3 %-50.8 % caused pathological abnormalities. These were enhanced positively charged NPs. Furthermore, observed that irrespective surface charge, after 2 h gradually internalized coelomocytes (∼0.12 μg per cell) mainly amassed at lysosomes. Those agglomerations stimulated lysosomal membranes lose stability even rupture, resulting impeded autophagy process cellular clearance, eventually coelomocyte death. In comparison negatively nanoplastics, exerted 83 higher cytotoxicity. Our findings provide better understanding how posed harmful have important implications evaluating ecological

Язык: Английский

Процитировано

40
Polystyrene nanoplastics-induced lung apoptosis and ferroptosis via ROS-dependent endoplasmic reticulum stress DOI
Qiumei Wu, Chao Liu, Dan Liu

и другие.

The Science of The Total Environment, Год журнала: 2023, Номер 912, С. 169260 - 169260

Опубликована: Дек. 10, 2023

Язык: Английский

Процитировано

39
Atmospheric microplastic and nanoplastic: The toxicological paradigm on the cellular system DOI Creative Commons
Anmol Choudhury, Faizan Zarreen Simnani, Dibyangshee Singh

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 259, С. 115018 - 115018

Опубликована: Май 20, 2023

The increasing demand for plastic in our daily lives has led to global pollution. improper disposal of resulted a massive amount atmospheric microplastics (MPs), which further the production nanoplastics (NPs). Because its intimate relationship with environment and human health, microplastic nanoplastic contamination is becoming problem. are microscopic light, they may penetrate deep into lungs. Despite several studies demonstrating abundance air, potential risks remain unknown. small size, characterization presented significant challenges. This paper describes sampling procedures nanoplastics. study also examines numerous harmful effects particles on health other species. There void research toxicity airborne upon inhalation, toxicological future. Further needed determine influence pulmonary diseases.

Язык: Английский

Процитировано

38
Cutting Boards: An Overlooked Source of Microplastics in Human Food? DOI

Himani Yadav,

Md Rakib Hasan Khan,

Mohiuddin Quadir

и другие.

Environmental Science & Technology, Год журнала: 2023, Номер 57(22), С. 8225 - 8235

Опубликована: Май 23, 2023

Plastic cutting boards are a potentially significant source of microplastics in human food. Thus, we investigated the impact chopping styles and board materials on released during chopping. As progressed, effects microplastic release became evident. The mass number from polypropylene were greater than polyethylene by 5-60% 14-71%, respectively. Chopping was associated with vegetable (i.e., carrots) without carrots. Microplastics showed broad, bottom-skewed normal distribution, dominated <100 μm spherical-shaped microplastics. Based our assumptions, estimated per-person annual exposure 7.4-50.7 g 49.5 board. We further that person could be exposed to 14.5 71.9 million annually, compared 79.4 boards. preliminary toxicity study did not show adverse viability mouse fibroblast cells for 72 h. This identifies plastic as substantial food, which requires careful attention.

Язык: Английский

Процитировано

37