Hydrological and hydraulic drivers of microplastics in a rural river sourced from the UK’s largest opencast coal mine

Environmental Pollution, Год журнала: 2025, Номер 368, С. 125722 - 125722

Опубликована: Янв. 17, 2025

Microplastics (MPs) are ubiquitous in river and freshwater ecosystems. However, the hydraulic hydrological mechanisms that regulate activation emissions of MPs from both land surface subsurface into rivers not well understood. This study aims to quantify instream MP concentration load a remote headwater catchment (Taff Bargoed, Wales UK), which drains UK's largest opencast coal mine (Ffos-y-fran), over two-year period. Small fibers (< 1 mm) composed acrylic polyester dominated sampled Taff while less commonly observed fragments were mostly polysulfone. River concentrations ranged 0.27 - 28.87 MP/m³ (average: 14.6 ± 10.31 MP/m³), one order magnitude 0.08 3.04 MP/s (average:1.42 0.81 MP/s). Statistically significant relationships found between concentration, number dry weather hours discharge, indicated rainfall-runoff induced, source limited, dilution effects on concentration. A negligible relationship discharge was observed, suggests variability independent flow conditions, hours, Bargoed. Significant positive total suspended solids also indicating this may provide useful proxy for estimating variation No longitudinal 2 km reach where differences drainage area negligible, however, increased by factor 4 downstream an inflowing tributary, sourced Ffos-y-fran mine. Overall, results evidence mining activities can contribute rural rivers, with their contribution being regulated processes catchment.

Язык: Английский

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Review on personal protective equipment: Emerging concerns in micro(nano)plastic pollution and strategies for addressing environmental challenges

Environmental Research, Год журнала: 2024, Номер 257, С. 119345 - 119345

Опубликована: Июнь 6, 2024

Язык: Английский

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The micro(nano)plastics perspective: exploring cancer development and therapy

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 24, 2025

Microplastics, as an emerging environmental pollutant, have received widespread attention for their potential impact on ecosystems and human health. Microplastics are defined plastic particles less than 5 millimeters in diameter can be categorized primary secondary microplastics. Primary microplastics usually originate directly from industrial production, while formed by the degradation of larger items. capable triggering cytotoxicity chronic inflammation, may promote cancer through mechanisms such pro-inflammatory responses, oxidative stress endocrine disruption. In addition, improved bring new perspectives to therapy, studies drug carriers underway, showing high targeting bioavailability. Although current suggest association between certain cancers (e.g., lung, liver, breast cancers), long-term effects specific still need studied. This review aimed at exploring carcinogenicity promising applications therapy provides important directions future research emphasizes multidisciplinary collaboration address this global health challenge.

Язык: Английский

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Lewy body diseases and the gut

Molecular Neurodegeneration, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 30, 2025

Abstract Gastrointestinal (GI) involvement in Lewy body diseases (LBDs) has been observed since the initial descriptions of patients by James Parkinson. Recent experimental and human observational studies raise possibility that pathogenic alpha-synuclein (⍺-syn) might develop GI tract subsequently spread to susceptible brain regions. The cellular mechanistic origins ⍺-syn propagation disease are under intense investigation. Experimental LBD models have implicated important contributions from intrinsic gut microbiome, intestinal immune system, environmental toxicants, acting as triggers modifiers pathologies. Here, we review primary clinical observations link dysfunctions LBDs. We first provide an overview anatomy repertoire relevant for disease, with a focus on luminal-sensing cells epithelium including enteroendocrine express make direct contact nerves. describe interactions within resident microbes exogenous how these may directly contribute pathology along related metabolic immunological responses. Finally, critical knowledge gaps field highlighted, focusing pivotal questions remain some 200 years after dysfunction predict better understanding pathophysiologies influence risk progression will accelerate discoveries lead deeper overall potential therapeutic strategies targeting gut-brain axis delay, arrest, or prevent progression.

Язык: Английский

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Microplastics and Nanoplastics Increase Major Adverse Cardiac Events in Patients with Myocardial Infarction

Journal of Hazardous Materials, Год журнала: 2025, Номер 489, С. 137624 - 137624

Опубликована: Фев. 19, 2025

Microplastics and nanoplastics (MNPs) have implicated in cardiovascular disease preclinical studies. Our objective is to investigate the relationship between MNPs coronary arteries major adverse cardiac events (MACE) patients with myocardial infarction (MI).We conducted a prospective observational study involving undergoing angiography for MI. Coronary blood samples were analyzed presence of using pyrolysis-gas chromatography-mass spectrometry. A total 142 enrolled, 110 completing 31.5-month follow-up. Among them, 48 (43.6 %) had detectable polystyrene, 79 (71.8 polyethylene, 105 (95.4 polyvinyl chloride (PVC), 68 (61.8 polyamide 66 their blood. PVC concentration was higher who experienced MACE. Furthermore, levels positively associated proinflammatory factors (IL-1β, IL-6, IL-18, TNF-α), odds MACE (OR: 1.090, 95 %CI: 1.032-1.1523, P = 0.002). Notably, each 10-unit increase PVC, there 1.374-fold risk (OR=2.374, 1.366-4.128, Additionally, we collected thrombus from an additional 21 MI patients, finding that thrombi correlated inflammatory markers monocyte/macrophage infiltration.

Язык: Английский

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Microplastics exacerbate ferroptosis via mitochondrial reactive oxygen species-mediated autophagy in chronic obstructive pulmonary disease

Autophagy, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Microplastics (MPs) induce mitochondrial dysfunction and iron accumulation, contributing to macroautophagy/autophagy ferroptosis, which has increased susceptibility the exacerbation of chronic obstructive pulmonary disease (COPD); however, underlying mechanism remains unclear. We demonstrated that MPs intensified inflammation in COPD by enhancing autophagy-dependent ferroptosis (ADF) vitro vivo. In lung tissues patients with COPD, concentrations MPs, especially polystyrene microplastics (PS-MPs), were significantly higher than control group, as detected pyrolysis gas chromatography mass spectrometry (Py-GCMS), accumulation. The exposure PS-MPs, 2 μm size, resulted their being deposited lungs model mice optical vivo imaging, observed bronchial epithelial cells traced GFP-labeled PS-MPs. There impairments accompanied reactive oxygen species (mito-ROS) overproduction levels lysosome biogenesis acidification pDHBE PS-MP stimulation, triggering occurrence ferritinophagy ADF triggered acute (AECOPD). Reestablishing via mitochondria-specific ROS scavenging or inhibition alleviated excessive ameliorated AECOPD induced Collectively, our data initially revealed exacerbate mito-ROS-mediated autophagy sheds light on further hazard assessments human respiratory health potential therapeutic agents for COPD.

Язык: Английский

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zMicroplastics and nanoplastics co-exposure modulates chromium bioaccumulation and physiological responses in rats

Environment International, Год журнала: 2025, Номер unknown, С. 109421 - 109421

Опубликована: Март 1, 2025

The environmental fragmentation of plastics generates a mixture plastic particles various sizes, which frequently co-occur with other mobile and persistent pollutants. Despite the prevalence such scenarios, interaction between micro- nanoplastics (MNPs) their combined effects pollutants, as highly toxic hexavalent chromium (Cr(VI)), remain almost entirely unexplored in mammalian species. This study demonstrated that nanoplastic microplastic co-aggregate together influence Cr bioaccumulation patterns related physiological alterations rats. Following four-week repeated intragastric exposure Wistar rats to MNPs Cr(VI), either alone or combination, significantly enhanced liver, heart, brain, skin. Under co-exposure conditions, Cr(VI) was primary driver cellular observed blood, including shifts immune cell subpopulations (e.g., neutrophils, lymphocytes) red blood indices, while serum biochemistry reflected limited stress. per se decreased creatine kinase activity increased cholesterol levels. In summary, polystyrene increase distribution bioavailability, but does not uniformly exacerbate toxicity. Instead, may selectively alter responses, emphasizing need for deeper understanding potential health risks.

Язык: Английский

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Micro-and nanoplastics in soil: New insights, knowledge gaps and challenges

Chemosphere, Год журнала: 2025, Номер 373, С. 144117 - 144117

Опубликована: Янв. 25, 2025

Язык: Английский

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Adolescent exposure to micro/nanoplastics induces cognitive impairments in mice with neuronal morphological damage and multi-omic alterations

Environment International, Год журнала: 2025, Номер 197, С. 109323 - 109323

Опубликована: Фев. 7, 2025

Polystyrene micro/nanoplastics (MPs/NPs) are globally recognized environmental concerns due to their widespread pollution and detrimental effects on physiological functions. However, the neurotoxic underlying mechanisms of MPs/NPs brain function in adolescents remain incompletely understood. This study investigated polystyrene neurobehavioral adolescent mice, utilizing multi-omic analysis molecular biology assays explore potential mechanisms. Following oral exposure MPs (5 μm) or NPs (0.5 at 0.5 mg/day for 4 weeks, induced more severe cognitive impairment mice than MPs, as assessed by Morris water maze Y-maze tests. might be associated with neuron loss neurogenesis inhibition caused NPs, while dendritic spine mediated hippocampus. Furthermore, hippocampal transcriptome Western blotting indicated involvement PI3K/AKT pathway NPs-induced neurotoxicity. Meanwhile, pronounced disruptions metabolome gut microbiota, strong correlations were observed between changes metabolites bacteria. elucidated toxicity mechanism inducing providing insights into toxicological impacts strategies intervention.

Язык: Английский

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Recent advances in strontium ion removal from wastewater

Applied Materials Today, Год журнала: 2025, Номер 43, С. 102641 - 102641

Опубликована: Фев. 16, 2025

Язык: Английский

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