The Science of The Total Environment, Год журнала: 2024, Номер 919, С. 170893 - 170893
Опубликована: Фев. 10, 2024
Язык: Английский
Free Radical Biology and Medicine, Год журнала: 2024, Номер 213, С. 359 - 370
Опубликована: Янв. 28, 2024
Язык: Английский
Процитировано
6
International Immunopharmacology, Год журнала: 2024, Номер 134, С. 112165 - 112165
Опубликована: Май 1, 2024
Язык: Английский
Процитировано
6
Environment International, Год журнала: 2023, Номер 183, С. 108252 - 108252
Опубликована: Окт. 17, 2023
Understanding the atmospheric processes involving carbonaceous aerosols (CAs) is crucial for assessing air pollution impacts on human health and climate. The sources formation mechanisms of CAs are not well understood, making it challenging to quantify in models. Studies suggest residential wood combustion (RWC) traffic significantly contribute Europe's urban rural areas. Here, we used an chemistry model (MONARCH) three different emission inventories (two versions European-scale inventory CAMS-REG_v4 HERMESv3 detailed national Spain) assess uncertainties simulation source allocation (from traffic, RWC, shipping, fires others) Northeast Spain. For this, black carbon (BC) organic aerosol (OA) measurements performed at supersites representing environments (urban, regional remote) were used. Our findings show importance resolution input data accurately reproducing BC/OA observations. Even though emissions total particulate matter rather consistent between Spain, found discrepancies them mainly related spatiotemporal disaggregation (particularly relevant RWC) treatment condensable fraction RWC (changes speciation elemental/organic carbon). main contribution BC concentrations site accounting 71.1%/65.2% (January/July) close agreement with fossil derived from observations (78.8%/84.2%), followed by (12.8%/3%) shipping (5.4%/13.8%). An over-representation (winter) (summer) obtained CAMS-REG_v4. Noteworthy arise OA results due condensables a limited secondary production model. These offer insights into MONARCH's effectiveness simulating study highlights benefits combining new datasets modeling techniques refine better understand mitigate impacts.
Язык: Английский
Процитировано
16
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Авг. 3, 2023
As the outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first broke out in Hubei Province, China, at end 2019. It has brought great challenges and harms to global public health. SARS-CoV-2 mainly affects lungs is manifested as pulmonary disease. However, one biggest crises arises from emergence COVID-19-induced fibrosis. At present, there are still many questions about how induced fibrosis (PF) occurs treat regulate its long-term effects. In addition, an important process fibrosis, effect on epithelial-mesenchymal transition (EMT) may be factor driving PF. This review summarizes main pathogenesis treatment mechanisms related Starting with basic PF, such EMT, transforming growth factor-β (TGF-β), fibroblasts myofibroblasts, inflammation, macrophages, innate lymphoid cells, matrix metalloproteinases tissue inhibitors metalloproteinases, hedgehog pathway well Notch signaling. Further, we highlight importance EMT PF provide overview molecular mechanisms, which will facilitate future research propose new clinical therapeutic solutions for
Язык: Английский
Процитировано
14
The Science of The Total Environment, Год журнала: 2024, Номер 919, С. 170893 - 170893
Опубликована: Фев. 10, 2024
Язык: Английский
Процитировано
5