Frontiers in Physiology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 17, 2023
In
recent
years,
the
role
of
ferroptosis
in
pulmonary
fibrosis
has
garnered
increasing
interest
as
a
potential
therapeutic
target.
Pulmonary
is
pathological
process
characterized
by
accumulation
extracellular
matrix
affected
lung
tissues,
and
currently,
there
are
no
effective
therapies
for
preventing
or
reversing
fibrotic
lesions.
Ferroptosis
form
programmed
cell
death
that
regulated
network
enzymes
signaling
pathways.
Dysregulation
been
implicated
several
diseases,
including
fibrosis.
The
lipid
peroxides
course
causes
damage
to
membranes
other
cellular
components,
leading
ultimately
death.
Relevant
targets
intervention
include
key
enzymes,
such
glutathione
peroxidase
4,
transcription
factors
like
nuclear
factor
erythroid
2-related
2,
iron
chelation.
This
review
provides
an
overview
emerging
highlights
this
pathway.
Further
research
needed
develop
safe
approaches
targeting
treatment
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: March 18, 2024
In
the
last
decade,
ferroptosis
has
received
much
attention
from
scientific
research
community.
It
differs
other
modes
of
cell
death
at
morphological,
biochemical,
and
genetic
levels.
Ferroptosis
is
mainly
characterized
by
non-apoptotic
iron-dependent
caused
lipid
peroxide
excess
accompanied
abnormal
iron
metabolism
oxidative
stress.
recent
years,
more
studies
have
shown
that
closely
related
to
occurrence
development
lung
diseases.
COPD,
asthma,
injury,
fibrosis,
cancer,
infection
respiratory
diseases
become
third
most
common
chronic
worldwide,
bringing
serious
economic
psychological
burden
people
around
world.
However,
exact
mechanism
which
involved
in
progression
not
been
fully
revealed.
this
manuscript,
we
describe
ferroptosis,
targeting
signaling
pathways
proteins,
summarize
relationship
between
diseases,
explore
intervention
targeted
therapy
for
Environment International,
Journal Year:
2023,
Volume and Issue:
183, P. 108252 - 108252
Published: Oct. 17, 2023
Understanding
the
atmospheric
processes
involving
carbonaceous
aerosols
(CAs)
is
crucial
for
assessing
air
pollution
impacts
on
human
health
and
climate.
The
sources
formation
mechanisms
of
CAs
are
not
well
understood,
making
it
challenging
to
quantify
in
models.
Studies
suggest
residential
wood
combustion
(RWC)
traffic
significantly
contribute
Europe's
urban
rural
areas.
Here,
we
used
an
chemistry
model
(MONARCH)
three
different
emission
inventories
(two
versions
European-scale
inventory
CAMS-REG_v4
HERMESv3
detailed
national
Spain)
assess
uncertainties
simulation
source
allocation
(from
traffic,
RWC,
shipping,
fires
others)
Northeast
Spain.
For
this,
black
carbon
(BC)
organic
aerosol
(OA)
measurements
performed
at
supersites
representing
environments
(urban,
regional
remote)
were
used.
Our
findings
show
importance
resolution
input
data
accurately
reproducing
BC/OA
observations.
Even
though
emissions
total
particulate
matter
rather
consistent
between
Spain,
found
discrepancies
them
mainly
related
spatiotemporal
disaggregation
(particularly
relevant
RWC)
treatment
condensable
fraction
RWC
(changes
speciation
elemental/organic
carbon).
main
contribution
BC
concentrations
site
accounting
71.1%/65.2%
(January/July)
close
agreement
with
fossil
derived
from
observations
(78.8%/84.2%),
followed
by
(12.8%/3%)
shipping
(5.4%/13.8%).
An
over-representation
(winter)
(summer)
obtained
CAMS-REG_v4.
Noteworthy
arise
OA
results
due
condensables
a
limited
secondary
production
model.
These
offer
insights
into
MONARCH's
effectiveness
simulating
study
highlights
benefits
combining
new
datasets
modeling
techniques
refine
better
understand
mitigate
impacts.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 3, 2023
As
the
outbreak
of
COVID-19
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
first
broke
out
in
Hubei
Province,
China,
at
end
2019.
It
has
brought
great
challenges
and
harms
to
global
public
health.
SARS-CoV-2
mainly
affects
lungs
is
manifested
as
pulmonary
disease.
However,
one
biggest
crises
arises
from
emergence
COVID-19-induced
fibrosis.
At
present,
there
are
still
many
questions
about
how
induced
fibrosis
(PF)
occurs
treat
regulate
its
long-term
effects.
In
addition,
an
important
process
fibrosis,
effect
on
epithelial-mesenchymal
transition
(EMT)
may
be
factor
driving
PF.
This
review
summarizes
main
pathogenesis
treatment
mechanisms
related
Starting
with
basic
PF,
such
EMT,
transforming
growth
factor-β
(TGF-β),
fibroblasts
myofibroblasts,
inflammation,
macrophages,
innate
lymphoid
cells,
matrix
metalloproteinases
tissue
inhibitors
metalloproteinases,
hedgehog
pathway
well
Notch
signaling.
Further,
we
highlight
importance
EMT
PF
provide
overview
molecular
mechanisms,
which
will
facilitate
future
research
propose
new
clinical
therapeutic
solutions
for
Frontiers in Physiology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 17, 2023
In
recent
years,
the
role
of
ferroptosis
in
pulmonary
fibrosis
has
garnered
increasing
interest
as
a
potential
therapeutic
target.
Pulmonary
is
pathological
process
characterized
by
accumulation
extracellular
matrix
affected
lung
tissues,
and
currently,
there
are
no
effective
therapies
for
preventing
or
reversing
fibrotic
lesions.
Ferroptosis
form
programmed
cell
death
that
regulated
network
enzymes
signaling
pathways.
Dysregulation
been
implicated
several
diseases,
including
fibrosis.
The
lipid
peroxides
course
causes
damage
to
membranes
other
cellular
components,
leading
ultimately
death.
Relevant
targets
intervention
include
key
enzymes,
such
glutathione
peroxidase
4,
transcription
factors
like
nuclear
factor
erythroid
2-related
2,
iron
chelation.
This
review
provides
an
overview
emerging
highlights
this
pathway.
Further
research
needed
develop
safe
approaches
targeting
treatment
