Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
287, С. 117268 - 117268
Опубликована: Ноя. 1, 2024
Per-
and
polyfluoroalkyl
substances
(PFAS)
have
attracted
significant
attention
due
to
their
environmental
toxicity.
However,
the
detrimental
impact
of
PFAS
on
development
female
reproductive
system
remains
controversial.
In
this
study,
we
investigated
effects
three
specific
compounds
perfluorooctanoic
acid
(PFOA),
perfluorononanoic
(PFNA),
perfluorodecanoic
(PFDA)
ovarian
development.
Among
these
compounds,
PFDA
demonstrated
most
pronounced
cytotoxic
effect
granulosa
cells.
The
results
showed
that
a
200
μM
concentration
induced
cell
apoptosis
via
intrinsic
pathway
by
elevating
reactive
oxygen
species
(ROS)
levels
activating
Caspase-9
Caspase-3.
Furthermore,
triggered
necroptosis,
form
regulated
death
(RCD),
through
receptor-interacting
serine/threonine
kinase
1
(RIPK1),
receptor
interacting
protein
3
(RIPK3),
mixed-lineage
domain-like
(MLKL)
axis,
mediated
inhibition
canonical
proteolytic
enzyme
Caspase-8.
vivo
experiments
confirmed
mice
exposed
displayed
significantly
reduced
index
compared
control
group,
accompanied
evident
follicular
atresia.
Ovarian
tissues
from
PFDA-exposed
group
upregulated
necroptosis
markers,
which
were
effectively
mitigated
inhibiting
phosphorylation
RIPK1
at
Ser166.
Importantly,
study
provides
first
evidence
disrupts
novel
mechanism
involving
RIPK1-mediated
pathway,
alongside
detection
pathway.
This
greatly
expands
our
insight
into
death.
finding
highlights
potential
public
health
hazards
associated
with
exposure
emphasizes
need
for
further
research
fully
understand
its
broader
implications.
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 15, 2025
Recurrent
spontaneous
abortion
(RSA)
represents
a
significant
clinical
challenge,
with
its
underlying
mechanisms
yet
to
be
fully
elucidated.
Despite
advances
in
understanding,
the
precise
pathophysiology
driving
RSA
remains
unclear.
Angelica
sinensis,
traditional
herbal
remedy,
is
frequently
used
as
an
adjunctive
treatment
for
miscarriage.
However,
it
uncertain
whether
primary
active
component,
sinensis
polysaccharide
(ASP),
plays
definitive
role
therapeutic
effects.
The
specific
function
and
mechanism
of
ASP
context
require
further
investigation.
In
this
study,
we
sought
evaluate
autophagy
levels
at
maternal-fetal
interface
patients
mouse
model
treated
ASP,
complemented
by
comprehensive
metabolomic
analysis.
Autophagy
flux
decidua
was
compared
between
eight
healthy
pregnant
women.
Additionally,
changes
were
assessed
following
treatment,
embryos
placental
tissues
collected
subsequent
profiling.
Our
results
revealed
reduction
Beclin
1
protein
normal
pregnancy
group.
Conversely,
restored
autophagy-related
expression,
including
ATG7,
ATG16L,
1,
higher
than
those
observed
untreated
Metabolomic
analyses
identified
phosphatidylethanolamine
ASP-treated
control
groups,
differential
metabolites
enriched
pathways
related
glycolysis/gluconeogenesis,
glycerolipid
metabolism,
glycine,
serine,
threonine
metabolism.
Functional
assays
that
enhances
trophoblast
cell
proliferation,
migration,
invasion.
summary,
our
findings
demonstrate
diminished
activity
patients,
while
appears
restore
regulate
key
metabolic
pathways,
glycolysis/gluconeogenesis.
These
provide
new
insights
into
protective
RSA,
suggesting
potential
intervention
condition.
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Insulin
and
insulin-like
growth
factor
1
(IGF1)
play
key
roles
in
fetal
development.
However,
their
the
association
between
perfluoroalkyl
polyfluoroalkyl
substance
(PFAS)
exposure
remain
unclear.
In
this
study,
levels
of
34
PFAS,
IGF1,
insulin
were
measured
258
paired
mother-infant
serum
samples
collected
from
a
nested
case-control
study
Maoming
city.
Isomeric
perfluorooctanesulfonate
(PFOS)
significantly
increased
preterm
birth
or
low
weight
(PTB/LBW)
risk,
odds
ratios
for
∑2m,
3+4+5m,
iso,
branched
PFOS
1.50,
1.72,
1.61,
1.77,
respectively.
Cord
IGF1
could
explain
15.4,
13.4,
9.7,
11.9%
these
associations,
Additionally,
cord
mediated
12.3
to
44.6%
associations
isomers,
perfluorooctanoate
acid
(PFOA),
its
alternative
(perfluorobutanoic
acid:
PFBA)
with
index.
For
instance,
contributed
42.0%
(95%
Cl:
0.8,
140.0%),
42.7%
13.0,
110.0%),
43.0%
8.4,
130.0%)
z-scores
PFOS,
PFOA,
PFBA,
These
findings
suggest
that
plays
mediating
role
PFAS
growth.
Toxics,
Год журнала:
2025,
Номер
13(3), С. 187 - 187
Опубликована: Март 5, 2025
Chemicals
in
personal
care
and
consumer
products
are
suspected
to
disrupt
endocrine
function
affect
reproductive
health.
However,
the
link
between
mixed
exposure
long-term
amenorrhea
is
not
well
understood.
This
study
analyzed
data
from
684
women
(2013–2018
National
Health
Nutrition
Examination
Survey)
assess
eight
polyfluorinated
alkyl
substances
(PFASs),
15
phthalates
(PAEs),
six
phenols,
four
parabens.
Various
statistical
models
for
robustness
tests
mediation
analysis
were
used
explore
associations
with
role
of
serum
globulin.
Biological
mechanisms
identified
through
an
integrated
strategy
involving
target
key
chemicals
intersections,
pathway
analysis,
validation.
Results
showed
that
had
higher
levels
Perfluorodecanoic
acid,
Perfluorohexane
sulfonic
acid
(PFHxS),
Perfluorononanoic
n-perfluorooctanoic
(n_PFOA),
n-perfluorooctane
Perfluoromethylheptane
isomers.
Logistic
regression
different
adjustments
consistently
found
significant
elevated
PFAS
concentrations
increased
risk,
confirmed
by
Partial
Least
Squares
Discriminant
Analysis.
Mediation
revealed
globulin
partially
mediated
relationship
amenorrhea.
Network
suggested
PFHxS
n_PFOA
may
interact
Signal
Transducer
Activator
Transcription
3
(STAT3).
highlights
exposure,
particularly
n_PFOA,
amenorrhea,
STAT3
serving
as
mediators
underlying
mechanisms.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 30, 2025
In
recent
years,
the
number
of
people
with
type
2
diabetes
mellitus
(T2DM)
has
been
increasing,
and
there
is
obvious
familial
aggregation
T2DM.
Pregestational
gestational
are
most
common
chronic
conditions
during
pregnancy.
However,
mechanism
by
which
maternal
preconception
hyperglycaemia
affects
glucolipid
metabolism
in
offspring
not
fully
understood.
Zebrafish
have
widely
used
to
construct
T2DM
models.
this
study,
we
established
a
successful
model
female
zebrafish
immersing
them
2%
glucose
solution
for
28
days.
The
results
showed
that
group
exhibited
damage
ovaries
livers.
Fasting
blood
glucose,
insulin,
cholesterol
triglycerides
were
increased
compared
control
group.
Moreover,
delayed
hatching
rate,
yolk
sac
area,
body
length
heart
rate
decreased
flow
velocity
observed
F1
larvae
from
Glucose,
insulin
lipid
prominently
affected
offspring.
Importantly,
influence
on
fasting
could
persist
into
adulthood
Transcriptomic
indicated
signalling
pathways
gluconeogenesis,
fat
digestion
absorption
amino
acid
enriched
perturbed
This
study
emphasised
impacts
glycolipid
offspring,
transferring
origin
disease
stage
providing
reference
further
research
aetiology
disorders.
