Transcriptomic and metabolomic profile changes in the liver of Sprague Dawley rat offspring after maternal PFOS exposure during gestation and lactation DOI Creative Commons
Ruiyuan Zhang,

Guoqi Yu,

Tingyu Luo

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 270, P. 115862 - 115862

Published: Dec. 28, 2023

Epidemiological and experimental research has indicated an association between perfluorooctane sulfonate (PFOS) exposure liver disease. However, the potential hepatotoxic effects mechanisms of low-level prenatal PFOS in offspring remain ambiguous. The objective this was to examine alterations transcriptomic metabolomic profiles rats at postnatal day (PND) 30 following gestational lactational (from 1 20 PND 21). Pregnant Sprague-Dawley were separated into a control group (3% starch gel solution, oral gavage) (0.03 mg/kg body weight per day, gavage). Histopathological changes sections observed by hematoxylin eosin staining. Biochemical analysis conducted evaluate glucose lipid metabolism. Transcriptomic analyses utilized identify significant genes metabolites associated with metabolism through integrated multi-omics analysis. No differences found measured biochemical parameters. In total, 167 differentially expressed (DEGs) related processes such as steroid biosynthesis, PPAR signaling pathway, fat digestion absorption identified group. Ninety-five altered exhibited group, heptaethylene glycol, lysoPE (0:0/18:0), lucidenic acid K, p-Cresol sulfate. DEGs significantly upregulated (P < 0.05). correlations that there inverse correlation all differential levels fasting blood glucose, high-density lipoprotein, triglycerides Our findings demystify early-life can lead offspring's liver, which provided mechanistic insights hepatotoxicity developmental toxicity environmentally relevant exposure.

Language: Английский

The mechanism of maternal inheritance of glycolipid metabolism disorder in a zebrafish model of type 2 diabetes DOI Creative Commons

Fuqi Yang,

Ying Zhang, Po‐Chung Ju

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 30, 2025

In recent years, the number of people with type 2 diabetes mellitus (T2DM) has been increasing, and there is obvious familial aggregation T2DM. Pregestational gestational are most common chronic conditions during pregnancy. However, mechanism by which maternal preconception hyperglycaemia affects glucolipid metabolism in offspring not fully understood. Zebrafish have widely used to construct T2DM models. this study, we established a successful model female zebrafish immersing them 2% glucose solution for 28 days. The results showed that group exhibited damage ovaries livers. Fasting blood glucose, insulin, cholesterol triglycerides were increased compared control group. Moreover, delayed hatching rate, yolk sac area, body length heart rate decreased flow velocity observed F1 larvae from Glucose, insulin lipid prominently affected offspring. Importantly, influence on fasting could persist into adulthood Transcriptomic indicated signalling pathways gluconeogenesis, fat digestion absorption amino acid enriched perturbed This study emphasised impacts glycolipid offspring, transferring origin disease stage providing reference further research aetiology disorders.

Language: Английский

Citations

0
Transcriptomics integrated with metabolomics reveals perfluorobutane sulfonate (PFBS) exposure effect during pregnancy and lactation on lipid metabolism in rat offspring DOI
Meng Xi,

Guoqi Yu,

Tingyu Luo

et al.

Chemosphere, Journal Year: 2023, Volume and Issue: 341, P. 140120 - 140120

Published: Sept. 9, 2023

Language: Английский

Citations

10
Ecosurveillance reveals subtle metabolic effects on the non-native cane toad (Rhinella marina) from low levels of accumulated environmental per- and polyfluoroalkyl substances DOI Creative Commons
Damian C. Lettoof, Marina Suzuki, Sandra Nilsson

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: 372, P. 125968 - 125968

Published: March 4, 2025

Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that persist in the environment, bioaccumulate, may have toxic effects. This study used non-native cane toads (Rhinella marina) to examine PFAS metal accumulation impacts large terrestrial amphibians from urban peri-urban areas. We quantified 38 compounds 36 environmental legacy metal(loid)s 52 adult toad livers collected six locations around Southeast Queensland, Australia, along a known gradient. Associations among PFAS, metal(loid) concentrations, whole-organism metrics were assessed. An omics-led approach assessed biochemical responses liver, muscle, fat gonad/egg tissues associated with these concentrations. Liver concentrations ranged 0.5 82.1 μg/kg ww, one male outlier at 452 ww (mean: 18 ± 21 SD excluding outlier). PFOS was most dominant (60 26 SD% of total), followed by PFDoDA (13 9 SD%). The liver statistically significant variation sex Al, As, Ca, Cu, Mn, Ni, Se, Sn, Sr V. Total had no associations metrics, body condition relative femur length showed weak interaction effect between Ni. Metabolic profiling revealed sex-specific differences linked total females showing broader metabolic perturbation. strongest signals glycerolipid metabolism, ether lipid fatty acid biosynthesis, though effects weak. levels low compared those previously recorded tertiary consumers aquatic vertebrates contaminated Despite minor metabolomic changes, overall health impact minimal. These findings contribute development tissue guideline values for wild amphibians, but further studies on higher additional amphibian species needed.

Language: Английский

Citations

0
Association of Personal Care and Consumer Product Chemicals with Long-Term Amenorrhea: Insights into Serum Globulin and STAT3 DOI Creative Commons
Ziyi Li, Xue Song,

Daniel Abdul Karim Turay

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 187 - 187

Published: March 5, 2025

Chemicals in personal care and consumer products are suspected to disrupt endocrine function affect reproductive health. However, the link between mixed exposure long-term amenorrhea is not well understood. This study analyzed data from 684 women (2013–2018 National Health Nutrition Examination Survey) assess eight polyfluorinated alkyl substances (PFASs), 15 phthalates (PAEs), six phenols, four parabens. Various statistical models for robustness tests mediation analysis were used explore associations with role of serum globulin. Biological mechanisms identified through an integrated strategy involving target key chemicals intersections, pathway analysis, validation. Results showed that had higher levels Perfluorodecanoic acid, Perfluorohexane sulfonic acid (PFHxS), Perfluorononanoic n-perfluorooctanoic (n_PFOA), n-perfluorooctane Perfluoromethylheptane isomers. Logistic regression different adjustments consistently found significant elevated PFAS concentrations increased risk, confirmed by Partial Least Squares Discriminant Analysis. Mediation revealed globulin partially mediated relationship amenorrhea. Network suggested PFHxS n_PFOA may interact Signal Transducer Activator Transcription 3 (STAT3). highlights exposure, particularly n_PFOA, amenorrhea, STAT3 serving as mediators underlying mechanisms.

Language: Английский

Citations

0
Co-exposure of PFASs, PAHs and metals, immune inflammation and triglyceride-glucose index: Exploring associations and mediation effects in children DOI
Miao Liu, Biao Zhang, Yuanyuan Zhang

et al.

Journal of Environmental Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Insights into the effect of benzotriazoles in liver using integrated metabolomic and transcriptomic analysis DOI Creative Commons

Ze‐Qin Guo,

Huimin Li, Wenmin Yu

et al.

Environment International, Journal Year: 2024, Volume and Issue: 187, P. 108716 - 108716

Published: May 1, 2024

Benzotriazoles (BTRs) are a class of benzoheterocyclic chemicals that frequently used as metal-corrosive inhibitors, both in industry and daily use. However, the exposure effect information on BTRs remains relatively limited. In this study, an integrated metabolomic transcriptomic approach was utilized to evaluate three BTRs, benzotriazole, 6-chloro-1-hydroxi-benzotriazole, 1-hydroxy-benzotriazole, mouse liver with results showing disrupted basal metabolic processes vitamin cofactor metabolism after 28 days. The expression several genes related inflammatory response aryl hydrocarbon receptor pathways, such Gstt2 Arntl, altered by BTRs. Exposure also affected metabolites involved immune system xenobiotic responses. cytochrome P450 family reveal potential detoxification mechanism liver. Taken together, our findings provide new insights into multilayer well resource for further exploration molecular mechanisms which occurs.

Language: Английский

Citations

3
Hunting Metabolic Biomarkers for Exposure to Per- and Polyfluoroalkyl Substances: A Review DOI Creative Commons

Xue Ma,

Delei Cai,

Qing Chen

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(7), P. 392 - 392

Published: July 19, 2024

Per- and polyfluoroalkyl substances (PFAS) represent a class of persistent synthetic chemicals extensively utilized across industrial consumer sectors, raising substantial environmental human health concerns. Epidemiological investigations have robustly linked PFAS exposure to spectrum adverse outcomes. Altered metabolites stand as promising biomarkers, offering insights into the identification specific pollutants their deleterious impacts on health. However, elucidating metabolic alterations attributable ensuing effects has remained challenging. In light this, this review aims elucidate potential biomarkers by presenting comprehensive overview recent metabolomics-based studies exploring toxicity. Details types, sources, patterns are provided. Furthermore, PFAS-induced liver toxicity, reproductive developmental cardiovascular glucose homeostasis disruption, kidney carcinogenesis synthesized. Additionally, thorough examination utilizing metabolomics delineate toxicity blood, liver, urine specimens is presented. This endeavors advance our understanding regarding associated toxicological effects.

Language: Английский

Citations

3
Prenatal exposures to endocrine disrupting chemicals: The role of multi-omics in understanding toxicity DOI Creative Commons

Margaret H. Rabotnick,

Jessa Ehlinger,

Ariana Haidari

et al.

Molecular and Cellular Endocrinology, Journal Year: 2023, Volume and Issue: 578, P. 112046 - 112046

Published: Aug. 19, 2023

Language: Английский

Citations

7
Perinatal exposure to perfluorooctane sulfonate and the risk of hepatic inflammation in rat offspring: Perturbation of gut-liver crosstalk DOI
Yongjie Liu,

Guoqi Yu,

Hannah Medsker

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 259, P. 119442 - 119442

Published: June 18, 2024

Language: Английский

Citations

2
Neurochemical mechanisms of perfluoroalkyl substances (PFAS) neurotoxic action DOI
Josephine M. Brown-Leung, Jason R. Cannon

Advances in neurotoxicology, Journal Year: 2023, Volume and Issue: unknown, P. 367 - 398

Published: Jan. 1, 2023

Language: Английский

Citations

4