Environmental contamination by bisphenols: from plastic production to modulation of the intestinal morphophysiology in experimental models

Food and Chemical Toxicology, Год журнала: 2025, Номер unknown, С. 115280 - 115280

Опубликована: Фев. 1, 2025

Язык: Английский

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Correlation between the interleukin-36 subfamily and gut microbiota in patients with liver cirrhosis: Implications for gut-liver axis imbalance

World Journal of Hepatology, Год журнала: 2025, Номер 17(4)

Опубликована: Апрель 25, 2025

Liver cirrhosis (LC) affect millions of people worldwide. The pathogenesis involves complex interactions between immune responses and gut microbiota. Recent studies have highlighted the role interleukin-36 (IL-36) subfamily in inflammation regulation. However, relationship serum IL-36 levels microbiota patients remains unclear. This study aimed to explore clinical significance their association with patients. To among Sixty-one were enrolled from Lihuili Hospital Ningbo University May 2022 November 2023 as LC group 29 healthy volunteers control (HC) group. expressions IL-36α, IL-36β, IL-36γ, IL-36Ra, IL-38 measured through ELISA, while 16S rRNA gene sequencing was employed rate microbial community human fecal samples. remarkably exceeded those HC (P < 0.05). related positively Child-Pugh score 0.05) prominently C absolute abundance harmful bacteria (Bacteroides, Bifidobacterium, Faecalibacterium) rose, beneficial (Firmicutes, Bacteroides, Escherichia-Shigella) notably decreased Lactobacillus 0.05), negatively Fusicatenibacter IL-36γ show promise potential biomarkers for progression, but further validation is required.

Язык: Английский

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Unravelling immunomodulatory effects of bisphenol A substitutes on human macrophages, T and B lymphocytes using in vitro models

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 300, С. 118406 - 118406

Опубликована: Май 30, 2025

Язык: Английский

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Transcriptomic Integration Analyses Uncover Common Bisphenol A Effects Across Species and Tissues Primarily Mediated by Disruption of JUN/FOS, EGFR, ER, PPARG, and P53 Pathways

Environmental Science & Technology, Год журнала: 2023, Номер 57(48), С. 19156 - 19168

Опубликована: Ноя. 18, 2023

Bisphenol A (BPA) is a common endocrine disruptor widely used in the production of electronic, sports, and medical equipment, as well consumer products like milk bottles, dental sealants, thermal paper. Despite its widespread use, current assessments BPA exposure risks remain limited due to lack comprehensive cross-species comparative analyses. To address this gap, we conducted study aimed at identifying genes fundamental molecular processes consistently affected by various species tissues, employing an effective data integration method bioinformatic Our findings revealed that led significant changes lipid metabolism, proliferation, apoptosis tissues/cells mammals, fish, nematodes. These were found be commonly adipose, liver, mammary, uterus, testes, ovary tissues. Additionally, through in-depth analysis signaling pathways influenced different observed JUN/FOS, EGFR, ER, PPARG, P53 pathways, along with their downstream key transcription factors kinases, all impacted BPA. provides compelling evidence indeed induces similar toxic effects across Furthermore, our investigation sheds light on underlying mechanisms responsible for these effects. By uncovering mechanisms, gain valuable insights into potential health implications associated exposure, highlighting importance awareness disruptor.

Язык: Английский

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Unveiling the next generation of bisphenol analogs and their impact on human health using in vitro methods

Emerging contaminants, Год журнала: 2023, Номер 10(2), С. 100296 - 100296

Опубликована: Дек. 7, 2023

Bisphenols are a group of organic compounds used frequently in industries to make plastics, coatings, and resins. These recently gained attention due their potential endocrine-disrupting effects. Bisphenol A (BPA) is the most studied compound among bisphenol group. Many countries have banned use because its toxic effects, which led invention other analogs, such as F, B, P, AF. studies found that analogs may also pose effects like BPA or can be even more toxic. Additionally, they exhibit genotoxicity, cytotoxicity, reproductive toxicity. Increased concentrations been detected abiotic environment human urine. In some regions, quantity similar higher than BPA. However, significant research gap exists concerning precise elucidation mechanism action, adverse physiological ramifications for health associated with analogs. Consequently, compelling need arises accumulation empirical data address consequences analog exposure ensure public preservation. The findings resulting from initiatives biomonitoring varied explorations into detrimental accentuate pressing requirement exhaustive investigation. This manuscript provides comprehensive review prevalence toxicity along existing knowledge gaps. It underscores these gaps effective regulatory strategies, contributing informed approach managing risks posed by

Язык: Английский

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Schisandra chinensis lignans regulate and cooperate with endogenous cannabinoid systems to ameliorate intestinal barrier injury associated with depression

Phytomedicine, Год журнала: 2024, Номер 133, С. 155929 - 155929

Опубликована: Июль 31, 2024

Язык: Английский

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Heterogeneity effects of bisphenol A and its substitute, fluorene-9-bisphenol, on intestinal homeostasis

Environment International, Год журнала: 2024, Номер 191, С. 108948 - 108948

Опубликована: Авг. 13, 2024

Bisphenol A (BPA) and its substitute fluorene-9-bisphenol (BHPF) are used in consumer products; however, their toxic effects on intestinal epithelium remain largely unknown. In this study, we combined organoids single-cell RNA sequencing to investigate the impact of BPA BHPF exposure cell composition, differentiation, function. Both compounds inhibited growth small organoids, with exhibiting a more potent inhibitory effect. did not significantly alter overall type composition; they led different alterations cell-cell communications. Gene Ontology enrichment analysis showed that exposures affected various biological processes, such as glutathione transferase activity, antioxidant lipid metabolism, type-specific compound-dependent manners. Trajectory demonstrated altered differentiation trajectory cells. To further connect cellular mechanism phenotypic vivo, constructed mouse model exposed or observed significant morphology, including reduced crypt depth villus length impaired stem proliferation self-renewal. These results provide novel insights into highlight potential risks these compounds. Our findings underscore importance evaluating safety substitutes contribute better understanding environmental chemicals gut health.

Язык: Английский

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Evaluation of THP-1 and Jurkat Cell Lines Coculture for the In Vitro Assessment of the Effects of Immunosuppressive Substances

Toxics, Год журнала: 2024, Номер 12(8), С. 607 - 607

Опубликована: Авг. 19, 2024

The strong appeal to reduce animal testing calls for the development and validation of in vitro, chemico silico models that would replace need vivo ex materials. A category requires such new approach methods is assessment immunosuppression can be induced by chemicals including environmental pollutants. To assess immunosuppressive action on monocytes lymphocytes, we mimicked whole-blood cytokine-release assay preparing an vitro coculture THP-1 Jurkat cell lines. We optimised its activation investigated effects known drugs with different mechanisms release proinflammatory cytokines. Decreased secretion IL-8 was achieved several therefore selected as appropriate marker immunosuppression. set environmentally occurring bisphenols, BPA, BPAP, BPP, BPZ, BPE, TCBPA BPS-MAE, were then applied model BPP BPZ found act potent immunosuppressants at micromolar concentrations.

Язык: Английский

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A “spore-like” oral nanodrug delivery platform for precision targeted therapy of inflammatory bowel disease

Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110180 - 110180

Опубликована: Июнь 1, 2024

Язык: Английский

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Comparative Analysis of Intestinal TLR4 Gene Expression and Functional Verification in Lepus yarkandensis and Oryctolagus cuniculus

Biochemical Genetics, Год журнала: 2024, Номер unknown

Опубликована: Сен. 30, 2024

Язык: Английский

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