A biochemical and histological evaluation of in vivo exposure of bisphenol P for multi-organ toxicity and pathology in rats DOI
Saadia Sattar, Asif Nadeem, Wasim Shehzad

и другие.

Toxicology and Industrial Health, Год журнала: 2024, Номер 40(4), С. 194 - 205

Опубликована: Фев. 12, 2024

Bisphenol P (BPP) is a structural analog of bisphenol A (BPA) and increasingly used as substitute BPA in commercial household applications. In recent years, BPP has been frequently detected terrestrial aquatic ecosystems. Very little epidemiological experimental information are available on the toxicity potential human animal systems, which very concerning view its increasing use. The current study evaluated biochemical histopathological effects rats. seven groups ( n = 5 rats/group) included BPA5 (5 mg), BPA50 (50 BPA100 (100 BPP5 BPP50 BPP100 mg) while remaining one group served untreated control. At end treatment, organs (liver, kidney, heart, lung) rats were harvested for oxidative stress analyses. significant p < .05) decrease was observed weight liver, lungs, kidneys similar to compared with control group. Further, also concentrations antioxidant enzymes (catalase, peroxidase, superoxide dismutase, glutathione peroxidase) kidneys, heart at highest two doses respective induced changes liver such nuclei distortion, excessive necrosis hepatocytes, shrinkage pyknosis cells disrupted cell structure (BPP100), cellular congestion degeneration hepatocytes (BPP50) BPA. treated showed varying kidney tissue, lung tissue conclusion, present indicated that induce alter histomorphological architecture different deleterious

Язык: Английский

Chemical profiling of paper recycling grades using GC-MS and LC-MS: An exploration of contaminants and their possible sources DOI Creative Commons
Nondumiso N. Mofokeng, Lawrence Mzukisi Madikizela,

Ineke Tiggelman

и другие.

Waste Management, Год журнала: 2024, Номер 189, С. 148 - 158

Опубликована: Авг. 27, 2024

Paper packaging made with recycled paperboard is used to pack various consumer goods that can include amongst others, electronics, toys, food, cosmetics, and stationery. Chemical profiling of the paper recycling grades in manufacture was undertaken investigate possible sources contaminants their propagation chain. Pre-consumer, retail post-consumer paper-based materials were collected at papermills, corrugators, grocery stores, household waste, solid waste disposal sites facilities. In GC-MS analysis, phthalates, long-chain aliphatic compounds, fatty acids most commonly detected compounds whilst phthalates bisphenols featured prevalently LC-MS analysis. The factors identified as likely contributors detection different chemical included presence wood derivatives, use certain additives during manufacturing, exposure from consumers, other environment. Waste mingling, recovery, sorting reprocessing into also shown influence profile materials. Sparse partial least squares-discriminate analysis indicated newspaper office had unique constituents, cartons have higher variability. By looking key stages recycling, this study showed persistence transformation must be evaluated when considering recyclability Further, it highlighted separation approaches may required reduce contaminant opportunities

Язык: Английский

Процитировано

0

Prenatal exposure to environmental bisphenols over time and their association with childhood asthma, allergic rhinitis and atopic dermatitis in the ECHO consortium DOI
Rachel L. Miller, Mengling Liu, Jenny Aalborg

и другие.

Environmental Pollution, Год журнала: 2024, Номер unknown, С. 125415 - 125415

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

0

A biochemical and histological evaluation of in vivo exposure of bisphenol P for multi-organ toxicity and pathology in rats DOI
Saadia Sattar, Asif Nadeem, Wasim Shehzad

и другие.

Toxicology and Industrial Health, Год журнала: 2024, Номер 40(4), С. 194 - 205

Опубликована: Фев. 12, 2024

Bisphenol P (BPP) is a structural analog of bisphenol A (BPA) and increasingly used as substitute BPA in commercial household applications. In recent years, BPP has been frequently detected terrestrial aquatic ecosystems. Very little epidemiological experimental information are available on the toxicity potential human animal systems, which very concerning view its increasing use. The current study evaluated biochemical histopathological effects rats. seven groups ( n = 5 rats/group) included BPA5 (5 mg), BPA50 (50 BPA100 (100 BPP5 BPP50 BPP100 mg) while remaining one group served untreated control. At end treatment, organs (liver, kidney, heart, lung) rats were harvested for oxidative stress analyses. significant p < .05) decrease was observed weight liver, lungs, kidneys similar to compared with control group. Further, also concentrations antioxidant enzymes (catalase, peroxidase, superoxide dismutase, glutathione peroxidase) kidneys, heart at highest two doses respective induced changes liver such nuclei distortion, excessive necrosis hepatocytes, shrinkage pyknosis cells disrupted cell structure (BPP100), cellular congestion degeneration hepatocytes (BPP50) BPA. treated showed varying kidney tissue, lung tissue conclusion, present indicated that induce alter histomorphological architecture different deleterious

Язык: Английский

Процитировано

0