Exposure to Per- and Polyfluoroalkyl Substances and Alterations in Plasma Microrna Profiles in Children DOI
Yijie Li, Brittney O. Baumert,

Nikos Stratakis

и другие.

Опубликована: Янв. 1, 2024

Background: Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that persist in the environment can accumulate humans, leading to adverse health effects. MicroRNAs (miRNAs) emerging biomarkers advance understanding of mechanisms PFAS effects on human health. However, little is known about associations between exposures miRNA alterations humans. Objective: To investigate concentrations levels children. Methods: Data from two distinct cohorts were utilized: 176 participants (average age 16.6 years; 75.6% female) Teen-Longitudinal Assessment Bariatric Surgery (Teen-LABS) cohort United States, 64 6.5 years, 39.1% Rhea study, a mother-child Greece. assessed plasma samples both studies. Associations individual examined after adjusting for covariates. Additionally, cumulative mixtures evaluated using an exposure burden score. Ingenuity Pathways Analysis was employed identify potential disease functions PFAS-associated miRNAs. Results: Plasma associated with 476 miRNAs Teen-LABs study 13 (FDR p < 0.1). Specifically, consistently decreased miR-148b-3p miR-29a-3p cohorts. Pathway analysis indicated PFAS-related linked numerous chronic pathways, including cardiovascular diseases, inflammatory conditions, carcinogenesis. Conclusion: Through screenings independent cohorts, this identified novel revealed involvement these several cancer inflammation-related pathways. Further studies warranted enhance our relationships risks, as and/or mediators complex

Язык: Английский

Novel Method for Simultaneously Untargeted Metabolome and Targeted Exposome Analysis in One Injection DOI

Pengwei Guan,

Yuting Wang, Tiantian Chen

и другие.

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Serum endogenous metabolites and coexisting exogenous compounds are closely related to human health. Metabolomics often uses high-resolution mass spectrometry (HRMS), but current exposomics studies typically rely on triple quadrupole tandem due lower concentrations in the body. As a result, metabolome-exposome-wide association (mEWAS) require combination of untargeted metabolomics several targeted methods measure more exposures, leading increased time sample consumption. In this study, novel method was proposed by leveraging advantages recently introduced Zeno MRMHR technology; it allows for simultaneous acquisition metabolome HRMS exposome multiple reaction monitoring (MRM) modes one injection. The signal responses MRM were comparable those HRMS. This rigorously validated, all standards had relative standard deviations (RSDs) below 20% intraday interday repeatability. Over 90% metabolic features exhibited RSDs these assessments. also broad quantification range, with limits (LLOQ) from 0.1 25 ng/mL higher (HLOQ) 2.5 1000 ng/mL. approach demonstratively applied type 2 diabetes mellitus cohort identify serum risk factors study metabolome-exposome association. To our knowledge, is first implementation unified analysis mode 210 injection, offering tool mEWAS research.

Язык: Английский

Процитировано

0
Exposure to Per‐ and Polyfluoroalkyl Substances and the Risk of Prostate and Ovarian Cancer: An Epidemiologic Meta‐Analysis DOI Open Access
Shenglan Yang, Hui Dong, X. Gou

и другие.

American Journal of Industrial Medicine, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants. Previous research has linked PFAS exposure to prostate ovarian cancer risk, however, the conclusions have been inconsistent. This purpose was determine relationship between at population level. We systematically reviewed three databases-PubMed, Web of Science, Embase-for from when these databases were established April 15, 2024. The quality retrieved evaluated using Newcastle-Ottawa Scale (NOS) measurement tool. Meta-analysis extracted data conducted Stata 18. also sensitivity subgroup analyses, as well Begg's Egger's tests. Twelve publications involved in analysis for cancer, six included ovary cancer. outcomes indicated that PFOS positively related (OR: 1.13, 95% CI: 1.00-1.28), while mixed 1.63, 1.49-1.78). source heterogeneity identified primarily attributable variations study design. No significant bias detected analysis. demonstrated an association both cancers. Further investigation is required clarify underlying mechanisms potential associations.

Язык: Английский

Процитировано

0
Health Impacts of Per- and Polyfluoroalkyl Substances (PFASs): A Comprehensive Review DOI Creative Commons
Csilla Mišľanová, Martina Valachovičová

Life, Год журнала: 2025, Номер 15(4), С. 573 - 573

Опубликована: Апрель 1, 2025

Per- and polyfluoroalkyl substances (PFASs) are among the persistent organic pollutants characterized by their persistence in environment, high mobility, adverse impact not only on ecosystem but also human health. The biggest challenges biomonitoring low concentrations of PFASs biological matrices presence matrix interferents samples. combination liquid chromatography with tandem mass spectrometry (LC-MS/MS) solid-phase extraction (SPE) as a sample preparation technique appears to be most suitable solution for achieving desired selectivity sensitivity PFAS determination. aim this review is describe possible sources PFASs, various matrices, analytical methods determining different using pretreatment techniques complex samples, well health risks associated exposure. studied include PFOA PFOS, which frequently detected such plasma, serum, breast milk. average range from 1.0 2.6 ng.mL−1 1.9 2.4 0.4 3.1 For were 2.0–4.0 ng.mL−1, 3.7–4.6 3.6–4.8 milk, respectively. significant effects exposure long-chain (such PFOS) lipid disorders, hypertension, diabetes mellitus, thyroid infertility, cancer, obesity, autism, neurodevelopmental issues, cardiovascular diseases, kidney liver disorders. It utmost importance monitor exposure, predict toxicity, develop effective strategies mitigate potential

Язык: Английский

Процитировано

0
Longitudinal association of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) exposure with lipid traits, in a healthy unselected population DOI Creative Commons

Yasrab Raza,

Julia S. El-Sayed Moustafa, Xinyuan Zhang

и другие.

Journal of Exposure Science & Environmental Epidemiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Abstract Background Perfluorooctanoic acid (PFOA) and Perfluorooctanesulfonic Acid (PFOS) are synthetic substances with long half-lives. Their presence is widespread pervasive, they noted for their environmental persistence. Research has shown these chemicals to be associated dyslipidaemia, although few studies have considered the long-term associations in general population. Objectives The aim of this study was consider longitudinal cross-sectional lipid phenotypes. Methods We investigated association total cholesterol (TC), low-density lipoprotein (LDL), high-density (HDL), triglycerides (TG), cholesterol: ratio (TC:HDL), a healthy unselected British population twins ( n = 2069), measured at three timepoints between 1996 2014. Results Serum levels PFOA PFOS decreased over time during period. demonstrate across serum both PFOS, finding positive TC (PFOA:β 0.51, p 1.9e−07; PFOS:β 0.24, 3.8e−05) LDL 0.61, 1.7e−11; 0.42, 1.6e−14), consistent negative HDL (β −0.12, 0.003) −0.25, <2e−16). also observe PFAS lipids all timepoints. Impact remain persistent environment, despite regulations, due structural properties, leaving humans open exposure. There less understanding how chronic low exposure chemicals, particularly within an population, may impact health outcomes. This reports 18-year window 5 phenotypes, highlighting that falling levels, lead hyperlipidaemia. further investigate understand time-dependent effects, demonstrating persist. work aids our on effect

Язык: Английский

Процитировано

0
Unveiling the Research Void: Exploring the Reproductive Effects of PFAS Compounds on Male Health DOI

Haoyang Qu,

Yating Han,

Cui Wang

и другие.

Advances in experimental medicine and biology, Год журнала: 2025, Номер unknown, С. 127 - 162

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Adverse health effects of PFAS DOI
Marcelo Andrade de Lima, Judith T. Zelikoff

EXPLORE, Год журнала: 2025, Номер 21(4), С. 103174 - 103174

Опубликована: Апрель 29, 2025

Язык: Английский

Процитировано

0
Quantitative Measurements of PFAS at Femtomole Concentrations via Integrated SERS and Single Photon Detection Methods DOI

Tianhang Huo,

Yehong Li, Silvana Andreescu

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Май 6, 2025

Abstract Per- and polyfluoroalkyl substances (PFAS) pose significant environmental health concerns, necessitating their efficient accurate identification to facilitate eventual mitigation from the environment. Surface-enhanced Raman spectroscopy (SERS) enables highly sensitive precise molecular identification, but trace-level detection of chemicals fluorescence interference remain challenges. Here, we present a uniform 3D AgNP@Si substrate for SERS, leveraging photon counting achieve susceptible low-fluorescence detection. This approach PFAS, including perfluorooctanoic acid (PFOA) perfluorooctane sulfonate (PFOS), at concentrations as low 10− 15 M, with Rhodamine 6G (R6G) used model analyte. Additionally, quantitative analysis demonstrated strong logarithmic relationship between intensity analyte concentration, high correlation coefficients (R2 = 0.98 R6G 0.97 PFOA PFOS). pioneering offers promising alternative current analytical techniques monitoring PFAS other contaminants in

Язык: Английский

Процитировано

0
Per- and poly-fluoroalkyl substances (PFAS) accelerate biological aging mediated by increased C-reactive protein DOI

Zong-Xi Zhao,

Jiayan Zhou,

Anye Shi

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 136090 - 136090

Опубликована: Окт. 9, 2024

Язык: Английский

Процитировано

3
Per- and Polyfluoroalkyl Substances Exacerbate the Prevalence of Plasmid-Borne Antibiotic Resistance Genes by Enhancing Natural Transformation, In Vivo Stability, and Expression in Bacteria DOI
Yingbin Li, Yunxuan Zhang, Xuran Liu

и другие.

Water Research, Год журнала: 2024, Номер 272, С. 122972 - 122972

Опубликована: Дек. 13, 2024

Язык: Английский

Процитировано

3
Cohort profile: The Obesity and Disease Development Sweden (ODDS) study, a pooled cohort DOI Creative Commons
Marisa da Silva, Josef Fritz, Innocent B. Mboya

и другие.

BMJ Open, Год журнала: 2024, Номер 14(7), С. e084836 - e084836

Опубликована: Июль 1, 2024

Purpose The Obesity and Disease Development Sweden (ODDS) study was designed to create a large cohort body mass index (BMI), waist circumference (WC) changes in weight WC, relation morbidity mortality. Participants ODDS includes 4 295 859 individuals, 2 165 048 men 130 811 women, Swedish cohorts national registers with information on assessed once (2 555 098 individuals) or more (1 740 761 individuals), total constituting 7 733 901 assessments at the age of 17–103 years 1963–2020 (recalled as 1911). Information WC is available 152 089 212 658 out whom 108 795 have repeated (in 512 273 assessments). mortality retrieved from registers, follow-up until end 2019–2021, varying between registers. Findings date Among all (of which 85% are objectively measured), median year, BMI (IQR) 1985 (1977–1994) 2001 (1991–2010) 19 (18–40) 30 (26–36) women 22.9 (20.9–25.4) kg/m 23.2 (21.2–26.1) women. Normal (BMI 18.5–24.9 ) present 67% 64% obesity (BMI≥30 5% 10% time first measured self-reported current assessment emigration, death 31.4 (21.8–40.8) 19.6 (9.3–29.0) During follow-up, 283 244 123 457 died. Future plans sample size long Study will provide robust results anthropometric measures risk common diseases causes deaths, novel findings subgroups rarer outcomes.

Язык: Английский

Процитировано

2