Exposure to Per- and Polyfluoroalkyl Substances and Alterations in Plasma Microrna Profiles in Children DOI
Yijie Li, Brittney O. Baumert,

Nikos Stratakis

et al.

Published: Jan. 1, 2024

Background: Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that persist in the environment can accumulate humans, leading to adverse health effects. MicroRNAs (miRNAs) emerging biomarkers advance understanding of mechanisms PFAS effects on human health. However, little is known about associations between exposures miRNA alterations humans. Objective: To investigate concentrations levels children. Methods: Data from two distinct cohorts were utilized: 176 participants (average age 16.6 years; 75.6% female) Teen-Longitudinal Assessment Bariatric Surgery (Teen-LABS) cohort United States, 64 6.5 years, 39.1% Rhea study, a mother-child Greece. assessed plasma samples both studies. Associations individual examined after adjusting for covariates. Additionally, cumulative mixtures evaluated using an exposure burden score. Ingenuity Pathways Analysis was employed identify potential disease functions PFAS-associated miRNAs. Results: Plasma associated with 476 miRNAs Teen-LABs study 13 (FDR p < 0.1). Specifically, consistently decreased miR-148b-3p miR-29a-3p cohorts. Pathway analysis indicated PFAS-related linked numerous chronic pathways, including cardiovascular diseases, inflammatory conditions, carcinogenesis. Conclusion: Through screenings independent cohorts, this identified novel revealed involvement these several cancer inflammation-related pathways. Further studies warranted enhance our relationships risks, as and/or mediators complex

Language: Английский

Longitudinal association of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) exposure with lipid traits, in a healthy unselected population DOI Creative Commons

Yasrab Raza,

Julia S. El-Sayed Moustafa, Xinyuan Zhang

et al.

Journal of Exposure Science & Environmental Epidemiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Background Perfluorooctanoic acid (PFOA) and Perfluorooctanesulfonic Acid (PFOS) are synthetic substances with long half-lives. Their presence is widespread pervasive, they noted for their environmental persistence. Research has shown these chemicals to be associated dyslipidaemia, although few studies have considered the long-term associations in general population. Objectives The aim of this study was consider longitudinal cross-sectional lipid phenotypes. Methods We investigated association total cholesterol (TC), low-density lipoprotein (LDL), high-density (HDL), triglycerides (TG), cholesterol: ratio (TC:HDL), a healthy unselected British population twins ( n = 2069), measured at three timepoints between 1996 2014. Results Serum levels PFOA PFOS decreased over time during period. demonstrate across serum both PFOS, finding positive TC (PFOA:β 0.51, p 1.9e−07; PFOS:β 0.24, 3.8e−05) LDL 0.61, 1.7e−11; 0.42, 1.6e−14), consistent negative HDL (β −0.12, 0.003) −0.25, <2e−16). also observe PFAS lipids all timepoints. Impact remain persistent environment, despite regulations, due structural properties, leaving humans open exposure. There less understanding how chronic low exposure chemicals, particularly within an population, may impact health outcomes. This reports 18-year window 5 phenotypes, highlighting that falling levels, lead hyperlipidaemia. further investigate understand time-dependent effects, demonstrating persist. work aids our on effect

Language: Английский

Citations

0
Synthesis, purification and characterisation of novel PFAS following nontarget analysis DOI Creative Commons
Ana R. L. Araújo,

А. М. Павлов,

Jon Eigill Johansen

et al.

Journal of Fluorine Chemistry, Journal Year: 2025, Volume and Issue: 282, P. 110398 - 110398

Published: Jan. 25, 2025

Language: Английский

Citations

0
Dose-Dependent PFESA-BP2 Exposure Increases Risk of Liver Toxicity and Hepatocellular Carcinoma DOI Creative Commons

Grace Kostecki,

Kai-Hsin Chuang,

Allen Buxton

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 98 - 98

Published: Feb. 5, 2025

Per- and polyfluoroalkyl substances (PFASs) are persistent highly bioaccumulative emerging environmental contaminants of concern that display significant toxic carcinogenic effects. An PFAS is PFESA-BP2, a ether sulfonic acid found in drinking water the serum humans animals. While PFESA-BP2-induced liver intestinal toxicity has been demonstrated, toxicological mechanisms potential PFESA-BP2 have remained relatively understudied. Here, we studied how different doses affect gene activity related to risk cancer such as hepatocellular carcinoma (HCC) mice exposed once daily through oral gavage for seven days. analysis key hepatic pathways suggested increased hepatotoxicity result exposure. Increased oxidative stress response was associated with all concentrations Liver pathways, including PXR/RXR activation fibrosis, showed dose-dependent alteration primarily at low doses, suggesting an inflammation injury. Additionally, HCC-specific cancer, particularly doses. Low-dose exposure (0.03 0.3 mg/kg-day) HCC carcinogenesis, indicated by tumor-related HCC-associated pathways. In contrast, these were inhibited high (3.0 6.0 mg/kg-day), accompanied HCC-suppressive The development mechanistically linked signaling HIF, EGF, NOTCH4, HGF, VEGF. Biomarkers risk, prognoses, diagnoses also identified Overall, our findings on hepatotoxic pathway patterns suggest increases development,

Language: Английский

Citations

0
Health Impacts of Per- and Polyfluoroalkyl Substances (PFASs): A Comprehensive Review DOI Creative Commons
Csilla Mišľanová, Martina Valachovičová

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 573 - 573

Published: April 1, 2025

Per- and polyfluoroalkyl substances (PFASs) are among the persistent organic pollutants characterized by their persistence in environment, high mobility, adverse impact not only on ecosystem but also human health. The biggest challenges biomonitoring low concentrations of PFASs biological matrices presence matrix interferents samples. combination liquid chromatography with tandem mass spectrometry (LC-MS/MS) solid-phase extraction (SPE) as a sample preparation technique appears to be most suitable solution for achieving desired selectivity sensitivity PFAS determination. aim this review is describe possible sources PFASs, various matrices, analytical methods determining different using pretreatment techniques complex samples, well health risks associated exposure. studied include PFOA PFOS, which frequently detected such plasma, serum, breast milk. average range from 1.0 2.6 ng.mL−1 1.9 2.4 0.4 3.1 For were 2.0–4.0 ng.mL−1, 3.7–4.6 3.6–4.8 milk, respectively. significant effects exposure long-chain (such PFOS) lipid disorders, hypertension, diabetes mellitus, thyroid infertility, cancer, obesity, autism, neurodevelopmental issues, cardiovascular diseases, kidney liver disorders. It utmost importance monitor exposure, predict toxicity, develop effective strategies mitigate potential

Language: Английский

Citations

0
Unveiling the Research Void: Exploring the Reproductive Effects of PFAS Compounds on Male Health DOI

Haoyang Qu,

Yating Han,

Cui Wang

et al.

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown, P. 127 - 162

Published: Jan. 1, 2025

Language: Английский

Citations

0
Adverse health effects of PFAS DOI
Marcelo Andrade de Lima, Judith T. Zelikoff

EXPLORE, Journal Year: 2025, Volume and Issue: 21(4), P. 103174 - 103174

Published: April 29, 2025

Language: Английский

Citations

0
Quantitative Measurements of PFAS at Femtomole Concentrations via Integrated SERS and Single Photon Detection Methods DOI

Tianhang Huo,

Yehong Li, Silvana Andreescu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Per- and polyfluoroalkyl substances (PFAS) pose significant environmental health concerns, necessitating their efficient accurate identification to facilitate eventual mitigation from the environment. Surface-enhanced Raman spectroscopy (SERS) enables highly sensitive precise molecular identification, but trace-level detection of chemicals fluorescence interference remain challenges. Here, we present a uniform 3D AgNP@Si substrate for SERS, leveraging photon counting achieve susceptible low-fluorescence detection. This approach PFAS, including perfluorooctanoic acid (PFOA) perfluorooctane sulfonate (PFOS), at concentrations as low 10− 15 M, with Rhodamine 6G (R6G) used model analyte. Additionally, quantitative analysis demonstrated strong logarithmic relationship between intensity analyte concentration, high correlation coefficients (R2 = 0.98 R6G 0.97 PFOA PFOS). pioneering offers promising alternative current analytical techniques monitoring PFAS other contaminants in

Language: Английский

Citations

0
Per- and poly-fluoroalkyl substances (PFAS) accelerate biological aging mediated by increased C-reactive protein DOI

Zong-Xi Zhao,

Jiayan Zhou,

Anye Shi

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136090 - 136090

Published: Oct. 9, 2024

Language: Английский

Citations

3
Cohort profile: The Obesity and Disease Development Sweden (ODDS) study, a pooled cohort DOI Creative Commons
Marisa da Silva, Josef Fritz, Innocent B. Mboya

et al.

BMJ Open, Journal Year: 2024, Volume and Issue: 14(7), P. e084836 - e084836

Published: July 1, 2024

Purpose The Obesity and Disease Development Sweden (ODDS) study was designed to create a large cohort body mass index (BMI), waist circumference (WC) changes in weight WC, relation morbidity mortality. Participants ODDS includes 4 295 859 individuals, 2 165 048 men 130 811 women, Swedish cohorts national registers with information on assessed once (2 555 098 individuals) or more (1 740 761 individuals), total constituting 7 733 901 assessments at the age of 17–103 years 1963–2020 (recalled as 1911). Information WC is available 152 089 212 658 out whom 108 795 have repeated (in 512 273 assessments). mortality retrieved from registers, follow-up until end 2019–2021, varying between registers. Findings date Among all (of which 85% are objectively measured), median year, BMI (IQR) 1985 (1977–1994) 2001 (1991–2010) 19 (18–40) 30 (26–36) women 22.9 (20.9–25.4) kg/m 23.2 (21.2–26.1) women. Normal (BMI 18.5–24.9 ) present 67% 64% obesity (BMI≥30 5% 10% time first measured self-reported current assessment emigration, death 31.4 (21.8–40.8) 19.6 (9.3–29.0) During follow-up, 283 244 123 457 died. Future plans sample size long Study will provide robust results anthropometric measures risk common diseases causes deaths, novel findings subgroups rarer outcomes.

Language: Английский

Citations

2
Exposure to per- and polyfluoroalkyl substances and alterations in plasma microRNA profiles in children DOI
Yijie Li, Brittney O. Baumert,

Nikos Stratakis

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 259, P. 119496 - 119496

Published: June 25, 2024

Language: Английский

Citations

1