bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 6, 2023
Abstract
Figure
G
protein-coupled
receptors
(GPCRs)
are
central
mediators
of
cell
signaling
and
physiological
function.
Despite
their
biological
significance,
GPCRs
have
not
been
widely
studied
in
the
field
toxicology.
Herein,
we
investigated
these
novel
targets
plastic
chemicals
using
a
high-throughput
drug
screening
assay
with
126
human
non-olfactory
GPCRs.
In
first-pass
screen,
tested
activity
triphenol
phosphate,
bisphenol
A,
diethyl
phthalate
as
well
three
real-world
mixtures
extracted
from
food
packaging
covering
all
major
polymer
types.
We
found
11
GPCR-chemical
interactions,
which
chemical
exhibited
most
robust
at
Adenosine
receptor
1
(ADORA1)
Melatonin
(MTNR1A)
confirmatory
secondary
screen.
further
confirmed
that
polyvinyl
chloride
polyurethane
products
contain
ADORA1
or
MTNRA1
agonists
pharmacological
knockdown
experiments.
Finally,
an
analysis
associated
gene
ontology
terms
suggests
MTNR1A
activation
may
be
linked
to
downstream
effects
on
circadian
metabolic
processes.
Our
findings
exemplify
diversity
endpoints
can
target
demonstrate
relevance
non-genomic
pathways
thus
far
remained
unexplored.
Cambridge Prisms Plastics,
Год журнала:
2024,
Номер
2
Опубликована: Янв. 1, 2024
An
abstract
is
not
available
for
this
content
so
a
preview
has
been
provided.
As
you
have
access
to
content,
full
PDF
via
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'Save
PDF'
action
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Journal of Exposure Science & Environmental Epidemiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 17, 2024
Over
1800
food
contact
chemicals
(FCCs)
are
known
to
migrate
from
articles
used
store,
process,
package,
and
serve
foodstuffs.
Many
of
these
FCCs
have
hazard
properties
concern,
still
others
never
been
tested
for
toxicity.
Humans
be
exposed
via
foods,
but
the
full
extent
human
exposure
all
is
unknown.
Resources Environment and Sustainability,
Год журнала:
2024,
Номер
17, С. 100163 - 100163
Опубликована: Июль 10, 2024
In
response
to
regulatory
demands
for
sustainable
practices,
there
has
been
a
significant
increase
in
the
use
of
recycled
materials
food
packaging,
particularly
when
incorporated
behind
functional
barriers.
This
study,
conducted
as
part
"ABA
Modeling"
project,
evaluates
migration
contaminants
from
non-decontaminated,
polyethylene
terephthalate
(rPET)
B-layer,
which
is
sandwiched
between
two
virgin
A-layers
three-layer
trays.
The
study
aims
assess
long-term
implications
safety
within
context
European
and
French
circular
economy
frameworks.
Using
modeling
approach
based
on
"worst-case"
scenarios
ten
–
similar
methodologies
employed
decontaminated
direct
contact
PET
levels
chemical
residues
are
analyzed
compared.
Findings
highlight
impact
co-extrusion
process
suitability
rPET
contact.
Additionally,
discusses
risks
challenges
recycling
sector,
managing
contamination
during
mechanical
recycling.
Recommendations
provided
improve
industrial
emphasizing
importance
ongoing
monitoring
ensure
sustainability
these
practices.
Environment International,
Год журнала:
2024,
Номер
191, С. 108949 - 108949
Опубликована: Авг. 15, 2024
Ageing
is
a
nature
process
of
microplastics
that
occurrs
daily,
and
human
beings
are
inevitably
exposed
to
aged
microplastics.
However,
systematic
understanding
ageing
status
its
toxic
effect
currently
still
lacking.
In
this
study,
plastic
cup
lids-originated
polypropylene
(PP)
were
UV-photoaged
until
the
carbonyl
index
(CI),
canonical
indicator
for
ageing,
achieved
0.08,
0.17,
0.22
0.28.
The
adverse
hepatic
these
PPs
(aPPs)
was
evaluated
in
Balb/c
mice
(75
ng/mL
water,
about
200
particles/day)
human-originated
liver
organoids
(LOs,
50
particles/mL,
ranged
from
5.94
13.15
ng/mL)
at
low-dose
equivalent
exposure
level.
Low-dose
PP
could
induce
reductive
stress
both
vitro
vivo,
by
elevating
NADH/NAD+ratio
CI-dependent
manner,
together
with
hepatoxicity
(indicated
increased
AST
secretion
cytotoxicity),
disrupted
genes
encoding
nutrients
transporters
NADH
subunits
accompanied
restricted
ATP
supply,
declined
mitochondrial
membrane
potential
complexI/IV
activities,
without
significant
increase
MDA
levels
liver.
These
changes
metabolism,
representing
circulatory
panel
increases
lactate,
triglyceride,
Fgf21
levels,
decreases
pyruvate
level,
linked
body
weight
gain
but
elevated
contents
following
aPPs
exposure.
Additionally,
assessing
LOs,
it
found
digestion
drastically
accelerated
worsen
energy
supply
upon
mitochondria,
"scattergun
effect"
induced
formation
micro-
nano-plastics
mixture
toward
NADH/NAD+imbalance.
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(11), С. 4872 - 4883
Опубликована: Март 5, 2024
G
protein-coupled
receptors
(GPCRs)
are
central
mediators
of
cell
signaling
and
physiological
function.
Despite
their
biological
significance,
GPCRs
have
not
been
widely
studied
in
the
field
toxicology.
Herein,
we
investigated
these
as
novel
targets
plastic
chemicals
using
a
high-throughput
drug
screening
assay
with
126
human
non-olfactory
GPCRs.
In
first-pass
screen,
tested
activity
triphenol
phosphate,
bisphenol
A,
diethyl
phthalate,
well
three
real-world
mixtures
extracted
from
food
packaging
covering
all
major
polymer
types.
We
found
11
GPCR-chemical
interactions,
which
chemical
exhibited
most
robust
at
adenosine
receptor
1
(ADORA1)
melatonin
(MTNR1A).
further
confirm
that
polyvinyl
chloride
polyurethane
products
contain
ADORA1
or
MTNRA1
agonists
confirmatory
secondary
screen
pharmacological
knockdown
experiments.
Finally,
an
analysis
associated
gene
ontology
terms
suggests
MTNR1A
activation
may
be
linked
to
downstream
effects
on
circadian
metabolic
processes.
This
work
highlights
disruption
caused
by
is
broader
than
previously
believed
demonstrates
relevance
nongenomic
pathways,
have,
thus
far,
remained
unexplored.
Frontiers in Toxicology,
Год журнала:
2025,
Номер
6
Опубликована: Янв. 10, 2025
In
the
United
States,
regulatory
agencies
have
approved
tens
of
thousands
chemicals
for
uses
ranging
from
agricultural
and
industrial
purposes,
in
food
personal
care
products,
other
consumer
goods
(Wang
et
al.,
2020).
For
many
these
chemicals,
exposures
to
human
populations
are
ubiquitous.
Many
them
been
allowed
be
used
with
little
or
no
scrutiny
agencies.
Using
as
an
example,
less
than
40%
US
Food
Drug
Administration
has
included
Americans'
diets
enough
data
estimate
amount
that
would
safe
public
ingest
(Neltner
2013);
vast
majority
lack
reproductive
developmental
toxicity
data.The
presence
bodies
people,
combined
adverse
effects
they
cause
controlled
animal
studies,
well
their
association
health
outcomes
populations,
suggest
approaches
protect
hazardous
insufficient
purposes
(Maffini
Vandenberg,
2017).
There
failures
testing
strategies
evaluate
analysis
hazard
by
(Sass
2024),
manage
risks
2024)
.Numerous
emerging
topics
on
chemical
safety
assessment
need
attention
scientific
community,
regulators,
regulated
industries.
These
include:Better
use
available
data:
The
mammary
gland
is
sensitive
exposures;
however,
organ
rarely
analyzed
properly
toxicology
(Kay
2022).
A
recent
study
found
76
potential
breast
carcinogens
migrating
contact
materials
sold
globally
(Parkinson
.
Science-based
policy
amendments
addressing
weaknesses
could
opportunity
cancer
prevention.The
endpoints
commonly
measured
conventional
not
kept
up
advances.
can
include
tools
measure
epigenetic
modifications
induced
exposures,
pollutants
microbiome,
relevant
endocrine
disruption,
complex
neurobehavioral
associated
conditions
such
autism
spectrum
disorder.
It
should
assumed
mechanistic
also
evidence
adversity.
exposure
glyphosate
glyphosate-based
herbicides
contributed
failed
embryonic
implantation
through
a
mechanism
likely
involve
genetic
uterus
(Lorenz
.Improving
assessments
environmental
monitoring:
Improving
risk
management
requires
more
improved
assessment;
updates
needed
(Vandenberg
2023).
settings
where
mixtures
(e.g.,
pesticides,
detergents,
disinfection
byproducts)
expected,
rapid
screening
techniques
discharge
pf
active
compounds
prevent
inadvertent
contamination
matrixes
(Aneck-Hahn
.The
concept
'essential
use'
decades-old
approach
minimize
phase-out
toxic
(Protocol,
1987).
More
recently,
European
Commission
announced
it
apply
same
eliminated
ozone-depleting
prioritize
"the
most
harmful"
(European
Commission:
Directorate-General
An
100
ECHA's
REACH
authorization
applications
information
qualify
substances'
"essential"
identified
major
challenges
this
categorization
including
clear
detailed
guidance
applicants
(Borchert
2024).One
critiques
considered
too
one
sector
but
products
toys
vs
food).
Globally
Harmonized
System
(GHS)
Classification
Labelling
Chemicals
useful
tool
enhance
protections
environment
if
achieve
aim
"one
substance,
assessment".
Union,
classification,
labeling
packaging
improve
regulations
(Kättström
However,
even
straightforward
continuously
avoid
ambiguity
how
labels
interpreted,
whether
self-classification
manufacturers
appropriate
consistent
between
companies.
Scientific
contributions
different
disciplines
fields
our
knowledge
chronic
diseases
increasing
concern
populations.
Stalled
agencies,
under
pressure
industry,
halted
progress
harmful
continue.
Conflicts
interest,
changes
governmental
administrations,
ecosystem
resistant
change
contributing
inertia
plagues
toxicology.
When
fail
public,
remedies
available,
educational
advocacy
campaigns
designed
shift
behaviors
away
citizen
petitions
push
take
action,
judicial
system
hold
both
polluting
industries
accountable
failure
act
harm
inflict
2024).Ultimately,
best
must
support
decision-making
authorities,
decisions
reviewed
latest
mind.
Approaches
testing,
assessment,
time.
static
puts
at
risk.
Globalization and Health,
Год журнала:
2024,
Номер
20(1)
Опубликована: Окт. 24, 2024
Among
the
crises
engulfing
world
is
symbiotic
rise
of
ultra-processed
foods
(UPFs)
and
plastics.
Together,
this
co-dependent
duo
generates
substantial
profits
for
agri-food
petrochemical
industries
at
high
costs
people
planet.
Cheap,
lightweight
highly
functional,
plastics
have
ideal
properties
that
enable
business
models
to
create
demand
low-cost,
mass-produced
hyper-palatable
UPFs
among
populations
worldwide,
hungry,
or
not.
Evidence
linking
UPF
consumption
deterioration
in
diet
quality
higher
risk
chronic
diseases
well-established
growing
rapidly.
At
same
time,
issue
plastic
food
contact
chemicals
(FCCs)
receiving
increasing
attention
human
health
community,
as
generation
dispersion
micro-
nanoplastics.
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(45), С. 20147 - 20159
Опубликована: Окт. 28, 2024
In
this
study,
we
show
that
low-density
polyethylene
films,
a
prevalent
choice
for
food
packaging
in
everyday
life,
generated
high
numbers
of
microplastics
(MPs)
and
hundreds
to
thousands
plastic-derived
dissolved
organic
matter
(DOM)
substances
under
simulated
preparation
storage
conditions.
Specifically,
the
plastic
film
66-2034
MPs/cm
Cambridge Prisms Plastics,
Год журнала:
2025,
Номер
unknown, С. 1 - 20
Опубликована: Янв. 16, 2025
An
abstract
is
not
available
for
this
content
so
a
preview
has
been
provided.
As
you
have
access
to
content,
full
PDF
via
the
'Save
PDF'
action
button.
