Beyond the nucleus: Plastic chemicals activate G protein-coupled receptors DOI Creative Commons
Molly McPartland, S. Edward Stevens, Zdeňka Bartošová

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Окт. 6, 2023

Abstract Figure G protein-coupled receptors (GPCRs) are central mediators of cell signaling and physiological function. Despite their biological significance, GPCRs have not been widely studied in the field toxicology. Herein, we investigated these novel targets plastic chemicals using a high-throughput drug screening assay with 126 human non-olfactory GPCRs. In first-pass screen, tested activity triphenol phosphate, bisphenol A, diethyl phthalate as well three real-world mixtures extracted from food packaging covering all major polymer types. We found 11 GPCR-chemical interactions, which chemical exhibited most robust at Adenosine receptor 1 (ADORA1) Melatonin (MTNR1A) confirmatory secondary screen. further confirmed that polyvinyl chloride polyurethane products contain ADORA1 or MTNRA1 agonists pharmacological knockdown experiments. Finally, an analysis associated gene ontology terms suggests MTNR1A activation may be linked to downstream effects on circadian metabolic processes. Our findings exemplify diversity endpoints can target demonstrate relevance non-genomic pathways thus far remained unexplored.

Язык: Английский

Primary plastic polymers: Urgently needed upstream reduction DOI Creative Commons
Juan Baztan, Bethany Jorgensen, Bethanie Carney Almroth

и другие.

Cambridge Prisms Plastics, Год журнала: 2024, Номер 2

Опубликована: Янв. 1, 2024

An abstract is not available for this content so a preview has been provided. As you have access to content, full PDF via the 'Save PDF' action button.

Язык: Английский

Процитировано

17
Evidence for widespread human exposure to food contact chemicals DOI Creative Commons
Birgit Geueke, Lindsey V. Parkinson, Ksenia J. Groh

и другие.

Journal of Exposure Science & Environmental Epidemiology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 17, 2024

Over 1800 food contact chemicals (FCCs) are known to migrate from articles used store, process, package, and serve foodstuffs. Many of these FCCs have hazard properties concern, still others never been tested for toxicity. Humans be exposed via foods, but the full extent human exposure all is unknown.

Язык: Английский

Процитировано

13
Assessment of chemical risks and circular economy implications of recycled PET in food packaging with functional barriers DOI Creative Commons
Phuong‐Mai Nguyen,

Carole Berrard,

Natacha Daoud

и другие.

Resources Environment and Sustainability, Год журнала: 2024, Номер 17, С. 100163 - 100163

Опубликована: Июль 10, 2024

In response to regulatory demands for sustainable practices, there has been a significant increase in the use of recycled materials food packaging, particularly when incorporated behind functional barriers. This study, conducted as part "ABA Modeling" project, evaluates migration contaminants from non-decontaminated, polyethylene terephthalate (rPET) B-layer, which is sandwiched between two virgin A-layers three-layer trays. The study aims assess long-term implications safety within context European and French circular economy frameworks. Using modeling approach based on "worst-case" scenarios ten – similar methodologies employed decontaminated direct contact PET levels chemical residues are analyzed compared. Findings highlight impact co-extrusion process suitability rPET contact. Additionally, discusses risks challenges recycling sector, managing contamination during mechanical recycling. Recommendations provided improve industrial emphasizing importance ongoing monitoring ensure sustainability these practices.

Язык: Английский

Процитировано

10
Editorial: Emerging topics on chemical safety assessment DOI Creative Commons
Maricel V. Maffini, Laura N. Vandenberg

Frontiers in Toxicology, Год журнала: 2025, Номер 6

Опубликована: Янв. 10, 2025

In the United States, regulatory agencies have approved tens of thousands chemicals for uses ranging from agricultural and industrial purposes, in food personal care products, other consumer goods (Wang et al., 2020). For many these chemicals, exposures to human populations are ubiquitous. Many them been allowed be used with little or no scrutiny agencies. Using as an example, less than 40% US Food Drug Administration has included Americans' diets enough data estimate amount that would safe public ingest (Neltner 2013); vast majority lack reproductive developmental toxicity data.The presence bodies people, combined adverse effects they cause controlled animal studies, well their association health outcomes populations, suggest approaches protect hazardous insufficient purposes (Maffini Vandenberg, 2017). There failures testing strategies evaluate analysis hazard by (Sass 2024), manage risks 2024) .Numerous emerging topics on chemical safety assessment need attention scientific community, regulators, regulated industries. These include:Better use available data: The mammary gland is sensitive exposures; however, organ rarely analyzed properly toxicology (Kay 2022). A recent study found 76 potential breast carcinogens migrating contact materials sold globally (Parkinson . Science-based policy amendments addressing weaknesses could opportunity cancer prevention.The endpoints commonly measured conventional not kept up advances. can include tools measure epigenetic modifications induced exposures, pollutants microbiome, relevant endocrine disruption, complex neurobehavioral associated conditions such autism spectrum disorder. It should assumed mechanistic also evidence adversity. exposure glyphosate glyphosate-based herbicides contributed failed embryonic implantation through a mechanism likely involve genetic uterus (Lorenz .Improving assessments environmental monitoring: Improving risk management requires more improved assessment; updates needed (Vandenberg 2023). settings where mixtures (e.g., pesticides, detergents, disinfection byproducts) expected, rapid screening techniques discharge pf active compounds prevent inadvertent contamination matrixes (Aneck-Hahn .The concept 'essential use' decades-old approach minimize phase-out toxic (Protocol, 1987). More recently, European Commission announced it apply same eliminated ozone-depleting prioritize "the most harmful" (European Commission: Directorate-General An 100 ECHA's REACH authorization applications information qualify substances' "essential" identified major challenges this categorization including clear detailed guidance applicants (Borchert 2024).One critiques considered too one sector but products toys vs food). Globally Harmonized System (GHS) Classification Labelling Chemicals useful tool enhance protections environment if achieve aim "one substance, assessment". Union, classification, labeling packaging improve regulations (Kättström However, even straightforward continuously avoid ambiguity how labels interpreted, whether self-classification manufacturers appropriate consistent between companies. Scientific contributions different disciplines fields our knowledge chronic diseases increasing concern populations. Stalled agencies, under pressure industry, halted progress harmful continue. Conflicts interest, changes governmental administrations, ecosystem resistant change contributing inertia plagues toxicology. When fail public, remedies available, educational advocacy campaigns designed shift behaviors away citizen petitions push take action, judicial system hold both polluting industries accountable failure act harm inflict 2024).Ultimately, best must support decision-making authorities, decisions reviewed latest mind. Approaches testing, assessment, time. static puts at risk.

Язык: Английский

Процитировано

1
Aged fragmented-polypropylene microplastics induced ageing statues-dependent bioenergetic imbalance and reductive stress: In vivo and liver organoids-based in vitro study DOI Creative Commons
Wei Cheng,

Hange Chen,

Yue Zhou

и другие.

Environment International, Год журнала: 2024, Номер 191, С. 108949 - 108949

Опубликована: Авг. 15, 2024

Ageing is a nature process of microplastics that occurrs daily, and human beings are inevitably exposed to aged microplastics. However, systematic understanding ageing status its toxic effect currently still lacking. In this study, plastic cup lids-originated polypropylene (PP) were UV-photoaged until the carbonyl index (CI), canonical indicator for ageing, achieved 0.08, 0.17, 0.22 0.28. The adverse hepatic these PPs (aPPs) was evaluated in Balb/c mice (75 ng/mL water, about 200 particles/day) human-originated liver organoids (LOs, 50 particles/mL, ranged from 5.94 13.15 ng/mL) at low-dose equivalent exposure level. Low-dose PP could induce reductive stress both vitro vivo, by elevating NADH/NAD+ratio CI-dependent manner, together with hepatoxicity (indicated increased AST secretion cytotoxicity), disrupted genes encoding nutrients transporters NADH subunits accompanied restricted ATP supply, declined mitochondrial membrane potential complexI/IV activities, without significant increase MDA levels liver. These changes metabolism, representing circulatory panel increases lactate, triglyceride, Fgf21 levels, decreases pyruvate level, linked body weight gain but elevated contents following aPPs exposure. Additionally, assessing LOs, it found digestion drastically accelerated worsen energy supply upon mitochondria, "scattergun effect" induced formation micro- nano-plastics mixture toward NADH/NAD+imbalance.

Язык: Английский

Процитировано

9
Beyond the Nucleus: Plastic Chemicals Activate G Protein-Coupled Receptors DOI Creative Commons
Molly McPartland, S. Edward Stevens, Zdeňka Bartošová

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер 58(11), С. 4872 - 4883

Опубликована: Март 5, 2024

G protein-coupled receptors (GPCRs) are central mediators of cell signaling and physiological function. Despite their biological significance, GPCRs have not been widely studied in the field toxicology. Herein, we investigated these as novel targets plastic chemicals using a high-throughput drug screening assay with 126 human non-olfactory GPCRs. In first-pass screen, tested activity triphenol phosphate, bisphenol A, diethyl phthalate, well three real-world mixtures extracted from food packaging covering all major polymer types. We found 11 GPCR-chemical interactions, which chemical exhibited most robust at adenosine receptor 1 (ADORA1) melatonin (MTNR1A). further confirm that polyvinyl chloride polyurethane products contain ADORA1 or MTNRA1 agonists confirmatory secondary screen pharmacological knockdown experiments. Finally, an analysis associated gene ontology terms suggests MTNR1A activation may be linked to downstream effects on circadian metabolic processes. This work highlights disruption caused by is broader than previously believed demonstrates relevance nongenomic pathways, have, thus far, remained unexplored.

Язык: Английский

Процитировано

7
A toxic relationship: ultra-processed foods & plastics DOI Creative Commons
Joe Yates, Suneetha Kadiyala, Megan Deeney

и другие.

Globalization and Health, Год журнала: 2024, Номер 20(1)

Опубликована: Окт. 24, 2024

Among the crises engulfing world is symbiotic rise of ultra-processed foods (UPFs) and plastics. Together, this co-dependent duo generates substantial profits for agri-food petrochemical industries at high costs people planet. Cheap, lightweight highly functional, plastics have ideal properties that enable business models to create demand low-cost, mass-produced hyper-palatable UPFs among populations worldwide, hungry, or not. Evidence linking UPF consumption deterioration in diet quality higher risk chronic diseases well-established growing rapidly. At same time, issue plastic food contact chemicals (FCCs) receiving increasing attention human health community, as generation dispersion micro- nanoplastics.

Язык: Английский

Процитировано

4
Rapid Generation of Microplastics and Plastic-Derived Dissolved Organic Matter from Food Packaging Films under Simulated Aging Conditions DOI
Liuwei Wang, Jing Gao, Wei‐Min Wu

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер 58(45), С. 20147 - 20159

Опубликована: Окт. 28, 2024

In this study, we show that low-density polyethylene films, a prevalent choice for food packaging in everyday life, generated high numbers of microplastics (MPs) and hundreds to thousands plastic-derived dissolved organic matter (DOM) substances under simulated preparation storage conditions. Specifically, the plastic film 66-2034 MPs/cm

Язык: Английский

Процитировано

4
Addressing the toxic chemicals problem in plastics recycling DOI Creative Commons
Bethanie Carney Almroth, Eric Carmona, Nnaemeka Chukwuone

и другие.

Cambridge Prisms Plastics, Год журнала: 2025, Номер unknown, С. 1 - 20

Опубликована: Янв. 16, 2025

An abstract is not available for this content so a preview has been provided. As you have access to content, full PDF via the 'Save PDF' action button.

Язык: Английский

Процитировано

0
Degree of food processing and serum poly- and perfluoroalkyl substance concentrations in the US National Health and Nutrition Examination Survey, 2003–2018 DOI
Diana C. Pacyga, Jessie P. Buckley, Eurídice Martínez Steele

и другие.

International Journal of Hygiene and Environmental Health, Год журнала: 2025, Номер 266, С. 114557 - 114557

Опубликована: Март 11, 2025

Язык: Английский

Процитировано

0