Environmental Research,
Год журнала:
2025,
Номер
unknown, С. 121278 - 121278
Опубликована: Март 1, 2025
Because
of
the
ubiquity
microplastics
(MPs)
in
environment
there
are
concerns
regarding
human
exposure.
In
this
study,
MPs
have
been
determined
three
physiological
fluids:
urine,
sputum
and
bronchoalveolar
fluid
(BALF);
from
30
adult
patients
Iran
with
respiratory
conditions.
A
total
nine
small
(20
-
100
μm)
mainly
green
red
fibres
polyethylene,
polypropylene
polystyrene
construction
were
detected
urine
samples
eight
participants.
By
contrast,
358
that
dominated
by
small,
white
transparent
fibres,
but
also
included
larger
(100
500
fragments
spherules,
samples.
Here,
a
broader
range
polymers
was
identified
polyurethane
dominant.
BALF
samples,
123
higher
proportion
along
spherules.
The
colour
distribution
these
similar
to
polymer
closer
These
observations
suggest
inhaled
ingested
might
be
fractionated
differently
though
body.
Further
research
is
required
elucidate
how
particles
than
theoretical
limits
(set
filtration
mechanisms)
present
fluids,
what
fractionation
processes
present,
whether
or
responsible
for
acute
chronic
health
impacts.
Human
health
is
being
threatened
by
environmental
microplastic
(MP)
pollution.
MPs
were
detected
in
the
bloodstream
and
multiple
tissues
of
humans,
disrupting
regular
physiological
processes
organs.
Nanoscale
plastics
can
breach
blood-brain
barrier,
leading
to
neurotoxic
effects.
How
cause
brain
functional
irregularities
remains
unclear.
This
work
uses
high-depth
imaging
techniques
investigate
within
vivo.
We
show
that
circulating
are
phagocytosed
lead
these
cells
obstruction
capillaries
cortex.
These
blockages
as
thrombus
formation
reduced
blood
flow
neurological
abnormalities
mice.
Our
data
reveal
a
mechanism
which
disrupt
tissue
function
indirectly
through
regulation
cell
interference
with
local
circulation,
rather
than
direct
penetration.
revelation
offers
lens
comprehend
toxicological
implications
invade
bloodstream.
European Heart Journal,
Год журнала:
2024,
Номер
45(38), С. 4099 - 4110
Опубликована: Сен. 6, 2024
Abstract
Emerging
evidence
indicates
that
chemical
exposures
in
the
environment
are
overlooked
drivers
of
cardiovascular
diseases
(CVD).
Recent
suggests
micro-
and
nanoplastic
(MNP)
particles
derived
largely
from
or
mechanical
degradation
plastics
might
represent
a
novel
CVD
risk
factor.
Experimental
data
preclinical
models
suggest
MNPs
can
foster
oxidative
stress,
platelet
aggregation,
cell
senescence,
inflammatory
responses
endothelial
immune
cells
while
promoting
range
metabolic
alterations
lead
to
disease
premature
death.
In
humans,
various
plastics,
including
polyethylene
polyvinylchloride,
have
been
detected
atherosclerotic
plaques
other
tissues,
pericardia,
epicardial
adipose
pericardial
myocardia,
left
atrial
appendages.
measurable
levels
within
thrombi
seem
accumulate
preferentially
areas
vascular
lesions.
Their
presence
carotid
is
associated
with
subsequent
increased
incidence
events.
To
further
investigate
possible
causal
role
CVD,
future
studies
should
focus
on
large,
prospective
cohorts
assessing
exposure
individuals
plastic-related
pollution,
routes
absorption,
existence
putative
safety
limit,
correspondence
between
accumulation
timing
development,
pathophysiological
mechanisms
instigated
by
pertinent
concentrations
MNPs.
Data
such
would
allow
design
preventive,
even
therapeutic,
strategies.
Meanwhile,
existing
reducing
plastic
production
use
will
produce
benefits
for
human
health.
This
goal
could
be
achieved
through
UN
Global
Plastics
Treaty
currently
negotiation.
Microplastics
are
ubiquitous,
widespread
environmental
pollutants
with
unavoidable
human
exposure.
Herein,
it
was
aimed
to
investigate
the
presence
of
microplastics
in
prostate
tissue.
Environmental Advances,
Год журнала:
2024,
Номер
17, С. 100555 - 100555
Опубликована: Июнь 5, 2024
Recent
evidence
indicates
that
the
human
womb
is
contaminated
with
a
variety
of
particulate
contaminants.
Microplastics
(MPs,
tiny
plastic
particles,
0.1
–
5000
µm)
generated
by
breakdown
larger
products
in
environment)
accumulation
placenta
has
recently
been
described.
In
addition,
recent
correlated
number
air
pollution
particulates
term
placentas
to
loading
these
particles
dust
from
gestational
parent
home.
The
current
study
sought
characterize
and
non-plastic
(NPP)
within
placenta.
Placenta
tissues
were
collected
healthy,
singleton
pregnancies
following
vaginal
(n=5)
caesarean
section
deliveries
at
tertiary
care
centre
located
an
urban
Canadian
city
(Ottawa,
ON),
detected
characterized
Raman
micro-spectroscopy.
Both
identified
all
examined,
average
1
±
1.2
MPs
/g
4
2.9
NPP
tissue.
Similar
tissue
concentrations
NNP
regions
(basal
plate,
chorionic
villous,
plate),
did
not
differ
according
mode
delivery.
ranged
size
(2
60
μm),
most
abundant
being
polyethylene
(PE),
polypropylene
(PP),
polystyrene
(PS)
polyvinyl
chloride
(PVC).
abundantly
carbon,
graphite,
lead
oxide.
Collectively,
results
demonstrate
foreign
including
MPs,
throughout
Given
vital
functions
supporting
fetal
growth
development,
potential
for
induce
toxicity,
further
investigations
into
harmful
effects
environmental
toxicants
on
maternal
health
warranted.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 7074 - 7074
Опубликована: Июнь 27, 2024
Microplastics
(MPs)
pervade
the
environment,
infiltrating
food
sources
and
human
bodies,
raising
concerns
about
their
impact
on
health.
This
review
is
focused
three
key
questions:
(i)
What
type
of
polymers
are
humans
most
exposed
to?
(ii)
prevalent
shapes
MPs
found
in
samples?
(iii)
Are
data
influenced
by
detection
limit
size
particles?
Through
a
systematic
literature
analysis,
we
have
explored
polymer
types
samples.
The
provide
evidence
that
polyester
commonly
detected
humans,
followed
polyamide,
polyurethane,
polypropylene,
polyacrylate.
Fibres
emerge
as
predominant
shape
across
all
categories,
suggesting
potential
environmental
contamination
from
textile
industry.
Studies
drinking
water
reported
small
particles,
contrast
to
larger
research,
particular
seafood.
Discrepancies
methodologies
different
reports
were
identified,
which
could
some
discussed
trends.
study
highlights
need
for
more
comprehensive
research
interactions
between
biological
systems
effects
toxicity,
together
with
standardised
analytical
accurately
assess
levels
exposure.
Understanding
these
dynamics
essential
formulating
effective
strategies
mitigate
health
implications
MP
pollution.
