Microplastics in the bloodstream can induce cerebral thrombosis by causing cell obstruction and lead to neurobehavioral abnormalities

Science Advances, Journal Year: 2025, Volume and Issue: 11(4)

Published: Jan. 22, 2025

Human health is being threatened by environmental microplastic (MP) pollution. MPs were detected in the bloodstream and multiple tissues of humans, disrupting regular physiological processes organs. Nanoscale plastics can breach blood-brain barrier, leading to neurotoxic effects. How cause brain functional irregularities remains unclear. This work uses high-depth imaging techniques investigate within vivo. We show that circulating are phagocytosed lead these cells obstruction capillaries cortex. These blockages as thrombus formation reduced blood flow neurological abnormalities mice. Our data reveal a mechanism which disrupt tissue function indirectly through regulation cell interference with local circulation, rather than direct penetration. revelation offers lens comprehend toxicological implications invade bloodstream.

Language: Английский

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Percutaneous coronary intervention leads to microplastics entering the blood: Interventional devices are a major source

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 476, P. 135054 - 135054

Published: June 27, 2024

Language: Английский

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Effects of microplastics on the kidneys: a narrative review

Kidney International, Journal Year: 2024, Volume and Issue: 106(3), P. 400 - 407

Published: June 18, 2024

Language: Английский

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Micro-nanoplastics and cardiovascular diseases: evidence and perspectives

European Heart Journal, Journal Year: 2024, Volume and Issue: 45(38), P. 4099 - 4110

Published: Sept. 6, 2024

Abstract Emerging evidence indicates that chemical exposures in the environment are overlooked drivers of cardiovascular diseases (CVD). Recent suggests micro- and nanoplastic (MNP) particles derived largely from or mechanical degradation plastics might represent a novel CVD risk factor. Experimental data preclinical models suggest MNPs can foster oxidative stress, platelet aggregation, cell senescence, inflammatory responses endothelial immune cells while promoting range metabolic alterations lead to disease premature death. In humans, various plastics, including polyethylene polyvinylchloride, have been detected atherosclerotic plaques other tissues, pericardia, epicardial adipose pericardial myocardia, left atrial appendages. measurable levels within thrombi seem accumulate preferentially areas vascular lesions. Their presence carotid is associated with subsequent increased incidence events. To further investigate possible causal role CVD, future studies should focus on large, prospective cohorts assessing exposure individuals plastic-related pollution, routes absorption, existence putative safety limit, correspondence between accumulation timing development, pathophysiological mechanisms instigated by pertinent concentrations MNPs. Data such would allow design preventive, even therapeutic, strategies. Meanwhile, existing reducing plastic production use will produce benefits for human health. This goal could be achieved through UN Global Plastics Treaty currently negotiation.

Language: Английский

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The first reported values of microplastics in prostate

BMC Urology, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 14, 2024

Microplastics are ubiquitous, widespread environmental pollutants with unavoidable human exposure. Herein, it was aimed to investigate the presence of microplastics in prostate tissue.

Language: Английский

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Particulate contamination of human placenta: Plastic and non-plastic

Environmental Advances, Journal Year: 2024, Volume and Issue: 17, P. 100555 - 100555

Published: June 5, 2024

Recent evidence indicates that the human womb is contaminated with a variety of particulate contaminants. Microplastics (MPs, tiny plastic particles, 0.1 – 5000 µm) generated by breakdown larger products in environment) accumulation placenta has recently been described. In addition, recent correlated number air pollution particulates term placentas to loading these particles dust from gestational parent home. The current study sought characterize and non-plastic (NPP) within placenta. Placenta tissues were collected healthy, singleton pregnancies following vaginal (n=5) caesarean section deliveries at tertiary care centre located an urban Canadian city (Ottawa, ON), detected characterized Raman micro-spectroscopy. Both identified all examined, average 1 ± 1.2 MPs /g 4 2.9 NPP tissue. Similar tissue concentrations NNP regions (basal plate, chorionic villous, plate), did not differ according mode delivery. ranged size (2 60 μm), most abundant being polyethylene (PE), polypropylene (PP), polystyrene (PS) polyvinyl chloride (PVC). abundantly carbon, graphite, lead oxide. Collectively, results demonstrate foreign including MPs, throughout Given vital functions supporting fetal growth development, potential for induce toxicity, further investigations into harmful effects environmental toxicants on maternal health warranted.

Language: Английский

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Microplastics Contamination in Carbonated Beverage: An Emerging Threat to Human Health in Bangladesh

Journal of Food Composition and Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 107312 - 107312

Published: Jan. 1, 2025

Language: Английский

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Microplastics in coastal and marine environments: A critical issue of plastic pollution on marine organisms, seafood contaminations, and human health implications

Journal of Hazardous Materials Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100663 - 100663

Published: Feb. 1, 2025

Language: Английский

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Mapping Microplastics in Humans: Analysis of Polymer Types, and Shapes in Food and Drinking Water—A Systematic Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7074 - 7074

Published: June 27, 2024

Microplastics (MPs) pervade the environment, infiltrating food sources and human bodies, raising concerns about their impact on health. This review is focused three key questions: (i) What type of polymers are humans most exposed to? (ii) prevalent shapes MPs found in samples? (iii) Are data influenced by detection limit size particles? Through a systematic literature analysis, we have explored polymer types samples. The provide evidence that polyester commonly detected humans, followed polyamide, polyurethane, polypropylene, polyacrylate. Fibres emerge as predominant shape across all categories, suggesting potential environmental contamination from textile industry. Studies drinking water reported small particles, contrast to larger research, particular seafood. Discrepancies methodologies different reports were identified, which could some discussed trends. study highlights need for more comprehensive research interactions between biological systems effects toxicity, together with standardised analytical accurately assess levels exposure. Understanding these dynamics essential formulating effective strategies mitigate health implications MP pollution.

Language: Английский

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From insects to mammals! Tissue accumulation and transgenerational transfer of micro/nano-plastics through the food chain

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136424 - 136424

Published: Nov. 8, 2024

Language: Английский

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