Journal of Nutrition, Год журнала: 2024, Номер 154(11), С. 3190 - 3202
Опубликована: Сен. 30, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 4024 - 4024
Опубликована: Апрель 4, 2024
The animal gut microbiota, comprising a diverse array of microorganisms, plays pivotal role in shaping host health and physiology. This review explores the intricate dynamics microbiome animals, focusing on its composition, function, impact host–microbe interactions. composition intestinal microbiota animals is influenced by ecology, including factors such as temperature, pH, oxygen levels, nutrient availability, well genetic makeup, diet, habitat, stressors, husbandry practices. Dysbiosis can lead to various gastrointestinal immune-related issues impacting overall productivity. Extracellular vesicles (EVs), particularly exosomes derived from play crucial intercellular communication, influencing transporting bioactive molecules across barriers like brain barriers. Dysregulation gut–brain axis has implications for disorders highlighting potential microbiota-derived EVs disease progression. Therapeutic approaches modulate probiotics, prebiotics, microbial transplants, phage therapy, offer promising strategies enhancing performance. Studies investigating effects therapy have shown results, with improving food safety poultry production systems. Understanding complex interactions between provides valuable insights into mechanisms underlying their Further research this field essential developing effective therapeutic interventions management promote well-being animals.
Язык: Английский
Процитировано
22
Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 136095 - 136095
Опубликована: Окт. 8, 2024
Язык: Английский
Процитировано
12
iMeta, Год журнала: 2025, Номер 4(2)
Опубликована: Фев. 26, 2025
Abstract Clinical nutritional support is recognized by Klinefner's Surgery as one of the four pivotal advancements in surgical practice during 20th century. Surgeons regard clinical nutrition a “life‐saving” discipline, preserving lives numerous critically ill patients and facilitating success many procedures. Parenteral (PN) serves crucial component therapy, while range complications associated with total parenteral (TPN) can significantly undermine efficacy patient treatment. Impaired intestinal homeostasis strongly occurrence progression TPN‐related infections, yet underlying mechanisms remain poorly understood. In this study, RNA sequencing single‐cell (scRNA‐Seq) revealed that reduced secretion interleukin‐22 (IL‐22) Group 3 innate lymphoid cells (ILC3s) significant factor contributing to onset infections. Additionally, through 16S ribosomal (16S rRNA) gene gut microbiota from chronic failure metagenomic analysis mice, we observed TPN abundance Lactobacillus murinus ( L. ), supplementation could promote IL‐22 ILC3s. Mechanistically, upregulates indole‐3‐carboxylic acid, which activates nuclear receptor Rorγt stimulate This pathway strengthens barrier integrity reduces infection susceptibility. Our findings enhance our understanding driving highlighting critical role maintaining immune improving outcomes.
Язык: Английский
Процитировано
2
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159546 - 159546
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Foods, Год журнала: 2025, Номер 14(8), С. 1416 - 1416
Опубликована: Апрель 19, 2025
Cyclophosphamide (CTX) is a widely used anticancer drug in clinical practice; however, its administration can lead to gastrointestinal damage and immune suppression. Lactobacillus murinus (L. murinus) has been shown regulate cell activity protect the system, showing potential application as functional food. The objective of this study was investigate effects L. ZNL-13 on CTX-induced intestinal mucosal injury gut microbiota mice. results demonstrated that significantly alleviated weight loss pathological damage. Moreover, mice, enhanced release factors, suppressed apoptosis, protected barrier. Additionally, it activated TLR4/NF-κB pathway, thereby promoting activity. Furthermore, contributed restoration microbial homeostasis by increasing relative abundance short-chain fatty acid-producing bacteria. Taken together, investigation highlights protecting barrier enhancing function while laying groundwork for development novel probiotic
Язык: Английский
Процитировано
1
Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Год журнала: 2024, Номер 15(1)
Опубликована: Ноя. 7, 2024
Abstract Probiotic extracellular vesicles (pEVs) are biologically active nanoparticle structures that can regulate the intestinal tract through direct or indirect mechanisms. They enhance barrier function in livestock and poultry help alleviate diseases. The specific effects of pEVs depend on their internal functional components, including nucleic acids, proteins, lipids, other substances. This paper presents a narrative review impact across various segments tract, exploring mechanisms action while highlighting limitations current research. Investigating which probiotics operate via could deepen our understanding provide theoretical foundation for application production.
Язык: Английский
Процитировано
6
Gut Microbes, Год журнала: 2024, Номер 16(1)
Опубликована: Ноя. 13, 2024
Lactic acid bacteria derived extracellular vesicles (LAB-EVs) are nano-sized and carry a variety of biological cargoes. LAB-EVs have proven to be potential mediators intercellular communication, serving not only the parental but also host cell in both physiology pathology. therapeutically beneficial various diseases through cell-free strategy. Particularly, EVs secreted from probiotics can exert health-promoting effects on humans. Additionally, excitement around has extended their use as drug carriers, since they traverse barriers. Nevertheless, significant challenges terms isolation, characterization, safety must addressed ensure clinical application LAB-EVs. Therefore, this review emphasizes isolation purification methods We introduce biogenesis, cargo sorting, functions The regulatory factors summarized discussed. Special attention is given interaction between host, ability maintain intestinal homeostasis, immunity inflammation induce diverse diseases. Furthermore, we summarize characterization LAB-EV cargoes by advanced analytical such proteomics. Finally, discuss opportunities means diagnosis treatment translation. In conclusion, scrutinizes current knowledge provides guidelines for proposing new perspectives future research field
Язык: Английский
Процитировано
6
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3478 - 3478
Опубликована: Март 20, 2024
The intestinal ecological environment plays a crucial role in nutrient absorption and overall well-being. In recent years, research has focused on the effects of extracellular vesicles (EVs) both physiological pathological conditions intestine. intestine does not only consume EVs from exogenous foods, but also those other endogenous tissues cells, even gut microbiota. alteration microbiota subsequently gives rise to changes organs systems, including central nervous system (CNS), namely microbiome-gut-brain axis, which exhibits significant involvement EVs. This review first an overview generation isolation techniques EVs, then mainly focuses elucidating functions derived various origins microenvironment, as well impacts altered microenvironment systems. Lastly, we discuss microbial cellular axis. enhances understanding specific roles system, thereby promoting more effective treatment strategies for certain associated diseases.
Язык: Английский
Процитировано
4
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Авг. 30, 2024
Probiotic extracellular vesicles are biochemically active structures responsible for biological effects elicited by probiotic bacteria.
Язык: Английский
Процитировано
3
Veterinary Medicine and Science, Год журнала: 2025, Номер 11(1)
Опубликована: Янв. 1, 2025
ABSTRACT Background Clostridium butyricum is a probiotic widely used in animal husbandry, and there evidence to suggest that it can alleviate intestinal inflammation pigs may be related its lipoteichoic acid (LTA), but the mechanism still unclear. Objective This study aimed determine regulatory effect potential of C. LTA on LPS‐stimulated porcine epithelial line‐J2 (IPEC‐J2). Methods IPEC‐J2 cells were treated with LPS different concentrations (0.05, 0.1 0.15 mM). After treatment 0.5, 1.5 4.5 h, cell culture media collected for measurement TNF‐α IL‐10 by using ELISA kits, RT‐qPCR Western blotting detections. Further elucidating pathway regulating gene expression inhibiting key proteins toll‐like receptor antagonists C34, PDTC, SB230580 U0126. Results High‐dose significantly promoted secretion anti‐inflammatory factor cells, inhibited pro‐inflammatory short term. TLR4 reduced protein phosphorylation levels p38, ERK1/2 p65. The inhibition TLR4, p65 caused LPS; increased TLR2 expression, ERK rather than expression. Conclusion Our found was an important component inflammatory response cells. mainly while stimulating IL‐10. Downstream p65, p38 involved both However, only increase not LTA. work supplemented provided theoretical basis application
Язык: Английский
Процитировано
0