Navigating the environmental dynamics, toxicity to aquatic organisms and human associated risks of an emerging tire wear contaminant 6PPD-quinone

Environmental Pollution, Год журнала: 2024, Номер 356, С. 124313 - 124313

Опубликована: Июнь 3, 2024

Язык: Английский

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Drosophila melanogaster as a tractable eco-environmental model to unravel the toxicity of micro- and nanoplastics

Environment International, Год журнала: 2024, Номер 192, С. 109012 - 109012

Опубликована: Сен. 17, 2024

Язык: Английский

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The spatio-temporal accumulation of 6 PPD-Q in greenbelt soils and its effects on soil microbial communities

Environmental Pollution, Год журнала: 2024, Номер 358, С. 124477 - 124477

Опубликована: Июнь 29, 2024

Язык: Английский

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Neurotoxicity from long-term exposure to 6-PPDQ: Recent advances

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 282, С. 116689 - 116689

Опубликована: Июль 15, 2024

The recent acceleration of industrialization and urbanization has brought significant attention to N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6-PPDQ), an emerging environmental pollutant from tire wear, due its long-term effects on the environment organisms. Recent studies suggest that 6-PPDQ can disrupt neurotransmitter synthesis release, impact receptor function, alter signaling pathways, potentially causing oxidative stress, inflammation, apoptosis. This review investigates potential neurotoxic prolonged exposure, mechanisms underlying cytotoxicity, associated health risks. We emphasize need for future research, including precise exposure assessments, identification individual differences, development risk assessments intervention strategies. article provides a comprehensive overview 6-PPDQ's behavior, impact, neurotoxicity in environment, highlighting key areas challenges research.

Язык: Английский

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Tire rubber-derived contaminants 6PPD and 6PPD-quinone reduce attachment and outgrowth of trophoblast spheroids onto endometrial epithelial cells

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 290, С. 117744 - 117744

Опубликована: Янв. 1, 2025

N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD), a synthetic additive widely used in the rubber industry, and its oxidized product 6PPD-quinone (6PPDQ), have garnered widespread attention as an emerging hazardous chemicals owing to their potential detrimental effects on aquatic ecosystem human health. The of 6PPD 6PPDq female reproductive tract, especially embryo implantation, remain unknown were investigated this study. We spheroid attachment outgrowth models BeWo trophoblastic spheroids Ishikawa cells surrogates for blastocyst endometrial epithelium, respectively. Treatment with up 48 h decreased viability dose- cell line-dependent manner (20-100 μM 10-100 6PPDQ both lines). At noncytotoxic concentration, exposure 1 10 reduced further inhibited invasion epithelial monolayer. A similar result was observed 6PPDQ-exposed groups. Gene expression profiling 6PPD- revealed that differentially regulated panel transcript markers toward overall downregulation receptivity invasion. study provides first proof adverse trophoblast during window warranting need vivo clinical studies.

Язык: Английский

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p-Phenylenediamines and their derived quinones: A review of their environmental fate, human exposure, and biological toxicity

Journal of Hazardous Materials, Год журнала: 2025, Номер 488, С. 137373 - 137373

Опубликована: Янв. 25, 2025

Язык: Английский

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6-PPD triggered lipid metabolism disorder and inflammatory response in larval zebrafish (Danio rerio) by regulating PPARγ/NF-κB pathway

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 125785 - 125785

Опубликована: Фев. 1, 2025

Язык: Английский

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GLOBAL TRENDS OF WASTE TIRE PYROLYSIS RESEARCH: A BIBLIOMETRIC ANALYSIS

Cleaner Energy Systems, Год журнала: 2025, Номер unknown, С. 100181 - 100181

Опубликована: Фев. 1, 2025

Язык: Английский

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6PPD induces apoptosis and autophagy in SH-SY5Y cells via ROS-mediated PI3K/AKT/mTOR pathway: in vitro and in silico approaches

Toxicology, Год журнала: 2025, Номер unknown, С. 154091 - 154091

Опубликована: Фев. 1, 2025

Язык: Английский

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6PPD impairs growth performance by inducing intestinal oxidative stress and ferroptosis in zebrafish

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Год журнала: 2025, Номер 293, С. 110161 - 110161

Опубликована: Фев. 21, 2025

Язык: Английский

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