Environmental Factors Ultraviolet A and Ozone Exacerbate the Repeated Inhalation Toxicity of 6PPD in Mice via Accelerating the Aging Reaction DOI
Xianjie Li,

Caixia Wu,

Ping Yang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 486, P. 137000 - 137000

Published: Dec. 25, 2024

Language: Английский

Navigating the environmental dynamics, toxicity to aquatic organisms and human associated risks of an emerging tire wear contaminant 6PPD-quinone DOI
Syed Shabi Ul Hassan Kazmi, Qiao Xu, Muhammad Tayyab

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 356, P. 124313 - 124313

Published: June 3, 2024

Language: Английский

Citations

11
Drosophila melanogaster as a tractable eco-environmental model to unravel the toxicity of micro- and nanoplastics DOI Creative Commons
Yán Wāng, Yang Jiang

Environment International, Journal Year: 2024, Volume and Issue: 192, P. 109012 - 109012

Published: Sept. 17, 2024

Language: Английский

Citations

6
The spatio-temporal accumulation of 6 PPD-Q in greenbelt soils and its effects on soil microbial communities DOI

Wei Wu,

Qiao Xu,

Jinhu Li

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 358, P. 124477 - 124477

Published: June 29, 2024

Language: Английский

Citations

5
Neurotoxicity from long-term exposure to 6-PPDQ: Recent advances DOI Creative Commons
Changsheng Ma,

Dong-Lun Li,

Fang Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 282, P. 116689 - 116689

Published: July 15, 2024

The recent acceleration of industrialization and urbanization has brought significant attention to N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6-PPDQ), an emerging environmental pollutant from tire wear, due its long-term effects on the environment organisms. Recent studies suggest that 6-PPDQ can disrupt neurotransmitter synthesis release, impact receptor function, alter signaling pathways, potentially causing oxidative stress, inflammation, apoptosis. This review investigates potential neurotoxic prolonged exposure, mechanisms underlying cytotoxicity, associated health risks. We emphasize need for future research, including precise exposure assessments, identification individual differences, development risk assessments intervention strategies. article provides a comprehensive overview 6-PPDQ's behavior, impact, neurotoxicity in environment, highlighting key areas challenges research.

Language: Английский

Citations

5
Tire rubber-derived contaminants 6PPD and 6PPD-quinone reduce attachment and outgrowth of trophoblast spheroids onto endometrial epithelial cells DOI Creative Commons
Jong Geol Lee, Seon Min Lee, Moonjung Hyun

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 290, P. 117744 - 117744

Published: Jan. 1, 2025

N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD), a synthetic additive widely used in the rubber industry, and its oxidized product 6PPD-quinone (6PPDQ), have garnered widespread attention as an emerging hazardous chemicals owing to their potential detrimental effects on aquatic ecosystem human health. The of 6PPD 6PPDq female reproductive tract, especially embryo implantation, remain unknown were investigated this study. We spheroid attachment outgrowth models BeWo trophoblastic spheroids Ishikawa cells surrogates for blastocyst endometrial epithelium, respectively. Treatment with up 48 h decreased viability dose- cell line-dependent manner (20-100 μM 10-100 6PPDQ both lines). At noncytotoxic concentration, exposure 1 10 reduced further inhibited invasion epithelial monolayer. A similar result was observed 6PPDQ-exposed groups. Gene expression profiling 6PPD- revealed that differentially regulated panel transcript markers toward overall downregulation receptivity invasion. study provides first proof adverse trophoblast during window warranting need vivo clinical studies.

Language: Английский

Citations

0
p-Phenylenediamines and their derived quinones: A review of their environmental fate, human exposure, and biological toxicity DOI
Xuefei Chen,

Yanna Le,

Wanyue Wang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137373 - 137373

Published: Jan. 25, 2025

Language: Английский

Citations

0
6-PPD triggered lipid metabolism disorder and inflammatory response in larval zebrafish (Danio rerio) by regulating PPARγ/NF-κB pathway DOI
Qiuhui Qian,

Ji Wu,

Cuizhen Wang

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 125785 - 125785

Published: Feb. 1, 2025

Language: Английский

Citations

0
GLOBAL TRENDS OF WASTE TIRE PYROLYSIS RESEARCH: A BIBLIOMETRIC ANALYSIS DOI Creative Commons

Zaki Siti Nuramirah Rabbani Muhammad Zaki,

Zainal Nurul Fatahah Asyqin,

Tay Chia Chay

et al.

Cleaner Energy Systems, Journal Year: 2025, Volume and Issue: unknown, P. 100181 - 100181

Published: Feb. 1, 2025

Language: Английский

Citations

0
6PPD induces apoptosis and autophagy in SH-SY5Y cells via ROS-mediated PI3K/AKT/mTOR pathway: in vitro and in silico approaches DOI
Ziwei Wang, Shutao Wang, Yingying Liu

et al.

Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 154091 - 154091

Published: Feb. 1, 2025

Language: Английский

Citations

0
6PPD impairs growth performance by inducing intestinal oxidative stress and ferroptosis in zebrafish DOI
Hao Xu,

Xiaoyu Mao,

Dashuang Mo

et al.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2025, Volume and Issue: 293, P. 110161 - 110161

Published: Feb. 21, 2025

Language: Английский

Citations

0