Nanofiltration (NF) application in drinking water treatment plants and the challenges of its concentrate management in China
Desalination,
Год журнала:
2025,
Номер
unknown, С. 118937 - 118937
Опубликована: Апрель 1, 2025
Язык: Английский
Hepatotoxicity in Carp (Carassius auratus) Exposed to Perfluorooctane Sulfonate (PFOS): Integrative Histopathology and Transcriptomics Analysis
Animals,
Год журнала:
2025,
Номер
15(4), С. 610 - 610
Опубликована: Фев. 19, 2025
Perfluorooctane
sulfonate
(PFOS)
contamination
poses
a
significant
environmental
threat
due
to
its
widespread
distribution
and
persistence.
However,
the
hepatotoxic
effects
of
PFOS
on
key
aquatic
species,
such
as
crucian
carp,
remain
understudied.
This
study
systematically
investigated
hepatotoxicity
underlying
molecular
mechanisms
associated
with
exposure
in
carp
over
21
day
period.
We
determined
96
h
50%
lethal
concentration
(LC50)
23.17
mg/L.
Histopathological
transcriptomic
analyses
confirmed
PFOS-induced
liver
damage
characterized
by
venous
congestion,
nucleolar
dissolution
cellular
vacuolation.
Transcriptomic
profiling
further
identified
1036
differentially
expressed
genes
(DEGs),
involving
critical
pathways
related
lipid
energy
metabolism,
immunity,
endocrine
regulation.
These
are
integral
development
nonalcoholic
fatty
disease
(NAFLD).
Specifically,
DEGs
metabolism
showed
changes,
while
those
involved
indicated
disrupted
ATP
production
mitochondrial
function.
Genes
immune
response
revealed
an
upregulation
pro-inflammatory
markers,
hormone
regulation
highlighted
alterations
signaling.
Our
findings
emphasized
that
exhibits
acute
toxicity
potentially
inducing
disrupting
multiple
physiological
systems.
research
provides
theoretical
foundation
for
mitigating
pollution
protecting
eco-health,
contributing
broader
ecological
conservation
biology
discussions.
Язык: Английский
Ecotoxicological effects of per- and polyfluoroalkyl substances in aquatic organisms: A review
Marine Pollution Bulletin,
Год журнала:
2025,
Номер
214, С. 117678 - 117678
Опубликована: Фев. 20, 2025
Язык: Английский
Perfluorobutane Sulfonate (PFOS) Accumulation in Tissues of Cherax quadricarinatus and Its Toxicity Mechanism
Toxics,
Год журнала:
2025,
Номер
13(4), С. 269 - 269
Опубликована: Апрель 1, 2025
Perfluoroctane
sulfonate
(PFOS)
is
an
emerging
pollutant
widely
existing
in
aquatic
environments
that
has
attracted
many
scholars’
attention.
Cherax
quadricarinatus
(C.
quadricarinatus)
are
crustaceans
live
freshwater
environments.
This
study
aimed
to
investigate
the
long-term
toxic
exposure
effect
of
PFOS
on
C.
quadricarinatus.
Three
environment
concentrations
(1
ng/L,
100
and
10
μg/L)
were
set
for
28
days
The
results
indicated
was
detected
serum,
muscle,
hepatopancreas
quadricarinatus,
order
accumulation
levels
as
follows:
>
serum
muscle.
Furthermore,
transcriptomics
showed
function
differentially
expressed
genes
(DEGs)
groups
related
biological
processes,
metabolism,
organic
system,
immune
response.
Kyoto
Encyclopedia
Genes
Genomes
enrichment
analysis
DEGs
significantly
enriched
lysosome
signaling
pathway,
retinol
binding,
fructose
mannose
glutathione
etc.,
pathway
most
significant,
which
key
effects
Язык: Английский
High-Throughput Single-Cell Mass Spectrometry Reveals Sex-Specific Metabolic Responses to 6:2 Chlorinated Polyfluoroalkyl Ether Sulfonate in Zebrafish Liver Cells
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
Compound
6:2
chlorinated
polyfluoroalkyl
ether
sulfonate
(6:2
Cl-PFESA)
is
an
emerging
per-
and
substance
(PFAS)
with
potential
toxicity
health
risks
to
biosystems
ecosystems.
Here,
we
developed
a
metabolomics
method
based
on
single-cell
mass
spectrometry
investigate
the
hepatotoxicity
heterogeneous
responses
in
zebrafish
exposed
Cl-PFESA.
Zebrafish
were
environmentally
relevant
concentration
(200
ng/L)
of
Cl-PFESA
for
14
days.
The
livers
dissociated
prepared
as
cell
suspensions
then
introduced
high-throughput
analysis
endogenous
metabolites
individual
primary
liver
cells.
Significant
sex-specific
heterogeneity
accumulation
was
observed
(p
<
0.05).
Metabolomics
revealed
perturbations
lipid
metabolism,
particularly
affecting
unsaturated
fatty
acids,
lipids,
sphingolipids
cells,
indicating
hepatotoxicity.
Sex-dependent
metabolic
evident:
males
showed
notable
changes
glucose
acid
whereas
females
experienced
pronounced
disruptions
glycerophospholipid
amino
pathways.
ROC
identified
biomarkers,
including
FA(18:3)
FA(16:1)
(AUC
>
0.85),
well
proline
phosphatidylcholine
0.90).
These
findings
reflect
dysregulation
highlight
responses.
This
study
demonstrates
feasibility
elucidate
cellular
mechanisms
pollutant
exposure,
offering
insights
into
precise
comprehensive
assessments
at
level.
Язык: Английский
Contribution of gut microbiota to hepatic steatosis following F-53B exposure from the perspective of glucose and fatty acid metabolism
Journal of Hazardous Materials,
Год журнала:
2024,
Номер
480, С. 136104 - 136104
Опубликована: Окт. 9, 2024
Язык: Английский
Strategically using Yupingfeng polysaccharides to improve the growth performance, antioxidant capacity, liver health, and lipid metabolism of largemouth bass (Micropterus salmoides) under a high-lipid diet
Zhuozhi Ou,
Yuhua Yue,
Xianjun Feng
и другие.
Aquaculture Reports,
Год журнала:
2024,
Номер
39, С. 102473 - 102473
Опубликована: Ноя. 11, 2024
Язык: Английский