Co-exposure to F-53B and Nanoplastics induced hepatic glucolipid metabolism disorders by the PI3K-AKT Signaling Pathway

Environmental Pollution, Год журнала: 2025, Номер 368, С. 125771 - 125771

Опубликована: Янв. 31, 2025

Язык: Английский

Understanding the Role of Exercise and Probiotic Interventions on Non-Alcoholic Fatty Liver Disease Alleviation in Zebrafish: Dialogue Between the Gut and Liver

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1360 - 1360

Опубликована: Фев. 6, 2025

Non-alcoholic fatty liver disease (NAFLD), the most prevalent chronic illness, is characterized by hepatic steatosis. Exercise and probiotics can regulate gut microbiota to treat NAFLD; however, their combined effects mechanisms of gut-liver communication remain unclear. Inconsistent results on probiotic efficacy further warrant investigation. In this study, zebrafish fed a high-fat diet (HFD) for six weeks were subjected swimming exercise (HFDE), intervention (HFDP), or combination both (HFDEP) 10 explore NAFLD corresponding mechanism. The showed that alleviation followed order HFDEP > HFDE HFDP. treatments effectively reduced Body Mass Index (BMI), relative weight, vacuolation density, lipid droplets in sections, triglyceride, free acid, glucose, pyruvic acid. contrast, single treatment had limited impact, suggesting complementary role treatment. Glucose acid metabolism central “gut–liver” axis. conversion glucose decreased synthesis esterification, accelerated transformation CO2 contributed improvement under treatments. This study provides promising theoretical groundwork potential prevention strategies NAFLD.

Язык: Английский

Cumulative inhibitory effect of 6:2 Chlorinated Polyfluorooctane Ether Sulfonate in anaerobic digestion processes

Journal of Hazardous Materials, Год журнала: 2025, Номер 493, С. 138372 - 138372

Опубликована: Апрель 21, 2025

Язык: Английский