Adverse Effects of Pesticides on the Ovary: Evidence from Epidemiological and Toxicological Studies
Environment & Health,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 22, 2025
Язык: Английский
Decidual Disrupting Effects of Low-Dose Benzophenone-Type UV Filters in Human Endometrial Stromal Cells via ER/PR/FOXO1 Signaling
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Exposure
to
endocrine
disrupting
chemicals
(EDCs),
particularly
benzophenone
(BP)-type
UV
filters,
has
been
epidemiologically
linked
endometrium-related
reproductive
risks
in
women.
However,
their
effects
on
hormone-driven
endometrial
events
and
key
receptor
signaling
at
the
human
cellular
level
remain
unexplored.
Herein,
using
primary
stromal
cells
(HESCs),
we
investigated
of
five
BP
congeners
deciphered
underlying
mechanism
decidualization,
a
functional
change
endometrium
preparing
for
pregnancy.
BP-8,
its
two
metabolites,
BP-3,
BP-1
10
nM
significantly
disrupted
progesterone-dependent
decidualization
HESCs,
marked
by
1.5–1.8-fold
2.2–2.6-fold
upregulation
IGFBP-1
LEFTY,
respectively.
Decidual
transcriptional
activators,
WNT-FOXO1,
were
induced
BPs,
which
are
implicated
G2
phase
cell
arrest
(from
3.26%
8.93%)
apoptosis
12.29%
25.61%).
Mechanistically,
inhibition
estrogen
α
(ERα)
effectively
alleviated
these
decidual
effects.
BPs
increased
transcription
ERα
progesterone
(PR)
enhanced
nuclear
translocation
interaction
between
PR
during
decidualization.
The
ERα-mediated
enhancement
activity
was
further
validated
response
element-luciferase
transfected
cells.
Collectively,
our
findings
elucidate
molecular
pathway
through
disrupt
via
ERα/PR/FOXO1,
providing
critical
mechanistic
insights
risk
assessment
structurally
related
EDCs.
Язык: Английский
Photoprotection in pregnancy: addressing safety concerns and optimizing skin health
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Март 27, 2025
Pregnancy
is
associated
with
physiological
skin
changes,
altered
response
to
UV
exposure
and
increased
risk
of
pigmentary
disorders
such
as
melasma
linea
nigra,
which
can
impact
quality
life.
This
review
explores
the
effects
photoprotection
during
pregnancy,
focusing
on
safety,
efficacy,
role
sunscreens
in
preventing
pregnancy-associated
hyperpigmentation
UV-induced
damage.
Sunscreen
use
pregnant
women
generally
low,
despite
evidence
supporting
benefits
broad-spectrum
mitigate
pigmentation
changes
prevent
DNA
damage
from
exposure.
Physiological
pregnancy
influence
sunscreen
selection;
ideally,
should
be
mineral-based,
cosmetically
acceptable,
potentially
supplemented
safe
organic
filters
optimize
cosmetic
acceptability
adherence,
free
ingredients
potential
risks
pregnancy.
Tinted
sunscreens,
provide
protection
against
high-energy
visible
light
(HEVL),
may
offer
enhanced
prevention
hyperpigmentary
disorders,
are
recommended
due
their
added
camouflage
benefits,
though
shade
options
ideally
match
diverse
tones.
Photoprotection
strategy
include
wide-brimmed
hats,
sun-safe
clothing
regular
high-SPF,
that
protect
UVB,
UVA,
HEVL.
Tinted,
mineral-based
formulations
optimal
for
providing
both
effective
benefits.
Язык: Английский
Exposure profiles to Benzophenones and their impacts on thyroid hormones in pregnant women
A. Khelfi,
Askoufes Houyam,
Agnieszka Dana
и другие.
Journal of Endocrinological Investigation,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 26, 2025
Язык: Английский
The association between maternal exposure to ten neonicotinoid insecticides and preterm birth in Guangxi, China
Environmental Pollution,
Год журнала:
2025,
Номер
unknown, С. 126477 - 126477
Опубликована: Май 1, 2025
Язык: Английский
Cohort Evidence Links Phthalate Exposure to Early Onset of Puberty in Chinese Girls
Environment & Health,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 5, 2025
Язык: Английский
The ENDOMIX perspective: how everyday chemical mixtures impact human health and reproduction by targeting the immune system
Biology of Reproduction,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 24, 2024
Abstract
Endocrine-disrupting
chemicals
are
natural
and
synthetic
compounds
found
ubiquitously
in
the
environment
that
interfere
with
hormonal-immune
axis,
potentially
impacting
human
health
reproduction.
Exposure
to
endocrine-disrupting
has
been
associated
numerous
risks,
such
as
neurodevelopmental
disorders,
metabolic
syndrome,
thyroid
dysfunction,
infertility,
cancers.
Nevertheless,
current
approach
establishing
causality
between
these
substances
disease
outcomes
limitations.
Epidemiological
experimental
research
on
faces
challenges
accurately
assessing
chemical
exposure
interpreting
non-monotonic
dose
response
curves.
In
addition,
most
studies
have
focused
single
or
simple
mixtures,
overlooking
complex
real-life
exposures
mechanistic
insights,
particular
regarding
chemicals'
impact
immune
system.
The
ENDOMIX
project,
funded
by
EU’s
Horizon
Health
Program,
addresses
integrating
epidemiological,
risk
assessment,
immunotoxicology
methodologies.
This
systemic
comprises
triangulation
of
cohort,
vitro,
vivo
data
determine
combined
effects
mixtures.
present
review
presents
discusses
literature
reproduction
context
immunotolerance
disruption
mode
action.
It
further
underscores
perspective
elucidate
immune-reproductive
health.
Язык: Английский