The ENDOMIX perspective: how everyday chemical mixtures impact human health and reproduction by targeting the immune system DOI Creative Commons
Sergio Gómez-Olarte, Volker Mailänder, Júlia Castro-Neves

et al.

Biology of Reproduction, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Abstract Endocrine-disrupting chemicals are natural and synthetic compounds found ubiquitously in the environment that interfere with hormonal-immune axis, potentially impacting human health reproduction. Exposure to endocrine-disrupting has been associated numerous risks, such as neurodevelopmental disorders, metabolic syndrome, thyroid dysfunction, infertility, cancers. Nevertheless, current approach establishing causality between these substances disease outcomes limitations. Epidemiological experimental research on faces challenges accurately assessing chemical exposure interpreting non-monotonic dose response curves. In addition, most studies have focused single or simple mixtures, overlooking complex real-life exposures mechanistic insights, particular regarding chemicals' impact immune system. The ENDOMIX project, funded by EU’s Horizon Health Program, addresses integrating epidemiological, risk assessment, immunotoxicology methodologies. This systemic comprises triangulation of cohort, vitro, vivo data determine combined effects mixtures. present review presents discusses literature reproduction context immunotolerance disruption mode action. It further underscores perspective elucidate immune-reproductive health.

Language: Английский

Adverse Effects of Pesticides on the Ovary: Evidence from Epidemiological and Toxicological Studies DOI Creative Commons
Linping Wang, Xiaochen Ma, Jing Liu

et al.

Environment & Health, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Language: Английский

Citations

0
Decidual Disrupting Effects of Low-Dose Benzophenone-Type UV Filters in Human Endometrial Stromal Cells via ER/PR/FOXO1 Signaling DOI
Tingjie Zhan,

Lilai Shen,

Yuyao Zhang

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Exposure to endocrine disrupting chemicals (EDCs), particularly benzophenone (BP)-type UV filters, has been epidemiologically linked endometrium-related reproductive risks in women. However, their effects on hormone-driven endometrial events and key receptor signaling at the human cellular level remain unexplored. Herein, using primary stromal cells (HESCs), we investigated of five BP congeners deciphered underlying mechanism decidualization, a functional change endometrium preparing for pregnancy. BP-8, its two metabolites, BP-3, BP-1 10 nM significantly disrupted progesterone-dependent decidualization HESCs, marked by 1.5–1.8-fold 2.2–2.6-fold upregulation IGFBP-1 LEFTY, respectively. Decidual transcriptional activators, WNT-FOXO1, were induced BPs, which are implicated G2 phase cell arrest (from 3.26% 8.93%) apoptosis 12.29% 25.61%). Mechanistically, inhibition estrogen α (ERα) effectively alleviated these decidual effects. BPs increased transcription ERα progesterone (PR) enhanced nuclear translocation interaction between PR during decidualization. The ERα-mediated enhancement activity was further validated response element-luciferase transfected cells. Collectively, our findings elucidate molecular pathway through disrupt via ERα/PR/FOXO1, providing critical mechanistic insights risk assessment structurally related EDCs.

Language: Английский

Citations

0
Photoprotection in pregnancy: addressing safety concerns and optimizing skin health DOI Creative Commons
Henry W. Lim, Jaime Piquero‐Casals, Sérgio Schalka

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 27, 2025

Pregnancy is associated with physiological skin changes, altered response to UV exposure and increased risk of pigmentary disorders such as melasma linea nigra, which can impact quality life. This review explores the effects photoprotection during pregnancy, focusing on safety, efficacy, role sunscreens in preventing pregnancy-associated hyperpigmentation UV-induced damage. Sunscreen use pregnant women generally low, despite evidence supporting benefits broad-spectrum mitigate pigmentation changes prevent DNA damage from exposure. Physiological pregnancy influence sunscreen selection; ideally, should be mineral-based, cosmetically acceptable, potentially supplemented safe organic filters optimize cosmetic acceptability adherence, free ingredients potential risks pregnancy. Tinted sunscreens, provide protection against high-energy visible light (HEVL), may offer enhanced prevention hyperpigmentary disorders, are recommended due their added camouflage benefits, though shade options ideally match diverse tones. Photoprotection strategy include wide-brimmed hats, sun-safe clothing regular high-SPF, that protect UVB, UVA, HEVL. Tinted, mineral-based formulations optimal for providing both effective benefits.

Language: Английский

Citations

0
Exposure profiles to Benzophenones and their impacts on thyroid hormones in pregnant women DOI
A. Khelfi,

Askoufes Houyam,

Agnieszka Dana

et al.

Journal of Endocrinological Investigation, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Language: Английский

Citations

0
The ENDOMIX perspective: how everyday chemical mixtures impact human health and reproduction by targeting the immune system DOI Creative Commons
Sergio Gómez-Olarte, Volker Mailänder, Júlia Castro-Neves

et al.

Biology of Reproduction, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Abstract Endocrine-disrupting chemicals are natural and synthetic compounds found ubiquitously in the environment that interfere with hormonal-immune axis, potentially impacting human health reproduction. Exposure to endocrine-disrupting has been associated numerous risks, such as neurodevelopmental disorders, metabolic syndrome, thyroid dysfunction, infertility, cancers. Nevertheless, current approach establishing causality between these substances disease outcomes limitations. Epidemiological experimental research on faces challenges accurately assessing chemical exposure interpreting non-monotonic dose response curves. In addition, most studies have focused single or simple mixtures, overlooking complex real-life exposures mechanistic insights, particular regarding chemicals' impact immune system. The ENDOMIX project, funded by EU’s Horizon Health Program, addresses integrating epidemiological, risk assessment, immunotoxicology methodologies. This systemic comprises triangulation of cohort, vitro, vivo data determine combined effects mixtures. present review presents discusses literature reproduction context immunotolerance disruption mode action. It further underscores perspective elucidate immune-reproductive health.

Language: Английский

Citations

2