Associations of Exposure to 24 Endocrine-Disrupting Chemicals with Perinatal Depression and Lifestyle Factors: A Prospective Cohort Study in Korea

Environments, Год журнала: 2025, Номер 12(1), С. 15 - 15

Опубликована: Янв. 6, 2025

During pregnancy, reproductive hormonal changes could affect the mental health of women, such as depression and anxiety. Previous studies have shown that exposure to endocrine disrupting chemicals (EDCs) is significantly associated with symptoms; however, results were inconsistent. We aimed examine association between 24 endocrine-disrupting in maternal urine perinatal their dietary lifestyle factors. Participants recruited from “No Environmental Hazards for Mother–Child” cohort Korea. Structured questionnaires asking factors evaluation depressive symptoms administered during antepartum (14 weeks gestation) postpartum (within four after birth) periods. Urine samples collected 242 119 women periods, respectively. To assess depression, we used Center Epidemiological Studies-Depression Scale Edinburgh Postnatal Depression Scale. Antepartum mono(2-ethyl-5-carboxypentyl) phthalate (MECPP) (1.50, 1.01–2.23) 1-hydroxypyrene (1-OHP) (0.05, 0–0.89) showed significant positive association. Additionally, associations mono(2-ethyl-5-oxohexyl) (MEOHP) (2.78, 1.00–7.70), mono(2-ethyl-5-hydroxyhexyl) (MEHHP) (2.79, 1.04–7.46), 2-hydroxynaphthalene (2-NAP) (7.22, 1.43–36.59), 2-hydroxyfluorene (2-FLU) (<0.01, 0–0.004). Some (consumption fish, fermented foods, cup noodles, popcorn) consumer product (use skin care, makeup, perfume, antibiotics, sunscreen, nail polish, new furniture, plastic tableware, detergent, paint, pesticide) concentration level chemicals. found several EDCs pregnancy period was dietary–lifestyle Women childbirth need actively seek out information about make efforts avoid them own fetal health.

Язык: Английский

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Parabens as the double-edged sword: Understanding the benefits and potential health risks

The Science of The Total Environment, Год журнала: 2024, Номер 954, С. 176547 - 176547

Опубликована: Сен. 30, 2024

Язык: Английский

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Rats' testicular toxicity induced by bisphenol A is lessened by crocin via an antiapoptotic mechanism and bumped P-glycoprotein expression

Toxicon, Год журнала: 2024, Номер 241, С. 107674 - 107674

Опубликована: Март 6, 2024

Язык: Английский

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Associations of pharmaceutical and personal care product chemical exposure with thyroid nodules and thyroid homeostasis

Journal of Environmental Sciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Urinary Exposure Level of Emerging Chemicals in Chinese Pregnant Women and Their Associations with Oxidative Stress

Emerging contaminants, Год журнала: 2025, Номер unknown, С. 100502 - 100502

Опубликована: Март 1, 2025

Язык: Английский

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Associations of exposure to polycyclic aromatic hydrocarbons with hearing in U.S. Adults

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 22, 2025

Polycyclic aromatic hydrocarbons (PAHs) pollution and hearing loss are important issues in the environment public health. However, current research still lacks data on their association real-world environments. This study included 658 American adults who participated National Health Nutrition Examination Survey (NHANES) from 2015 to 2016. The correlation between single PAH exposure was estimated by weighted logistic regression, overall mixed PAHs evaluated Bayesian kernel machine regression grouped quantile sum chemicals were identified this study. results showed that 1-Hydroxynaphthalene (1-OHNa) positively correlated with condition, level threshold (OR = 1.41, 95% CI 1.08-1.84, P < 0.01; OR 1.04-1.87, 0.05; 4.34, 1.74-10.81, 0.01, respectively). And 1-Hydroxypyrene (1-OHP) condition 1.83, 0.99-3.36, 5.83, 1.31-26.03, 0.05, respectively) after using covariate correction. of BKMR WQS indicated a positive decreased hearing, higher PAHs, greater risk loss. Further analysis revealed 1-OHP an chemical substance related hearing. result consistent model. These insights provide critical new perspective highlighting urgent need for strategies reduce environmental protect human

Язык: Английский

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Multi-omics profiling of dairy cattle oxidative stress identifies hindgut-derived Phascolarctobacterium succinatutens exhibiting antioxidant activity

npj Biofilms and Microbiomes, Год журнала: 2025, Номер 11(1)

Опубликована: Апрель 22, 2025

An imbalance between oxidative and antioxidant processes in the host can lead to excessive oxidation, a condition known as stress (OS). Although changes hindgut microbiota have been frequently linked OS, specific microbial metabolic underpinnings of this association remain unclear. In study, we enrolled 81 postpartum Holstein cows stratified them into high (HOS, n = 9) low (LOS, groups based on index (OSi). Using multi-omics approach, performed 16S rRNA gene sequencing evaluate diversity, conducted metagenomic analysis identify functional bacteria, utilized untargeted metabolomics profile serum metabolites. Our analyses revealed elevated levels kynurenine, formyl-5-hydroxykynurenamine, 5-hydroxyindole-3-acetic acid LOS dairy cows. Additionally, had higher abundance short-chain fatty acids (SCFAs)-producing including Bacteroidetes bacterium, Paludibacter propionicigenes, Phascolarctobacterium succinatutens (P. succinatutens), which were negatively correlated with OSi. To explore potential role these bacteria mitigating administered P. (108 cfu/day for 14 days) C57BL/6 J mice (n 10). Oral administration significantly increased total capacity, decreased oxidants, reduced OSi mice. Moreover, treatment promoted activation Nrf2-Keap1 pathway, enhancing enzymatic activities GSH-Px SOD, well concentrations acetate propionate colon. conclusion, our findings suggest that systemic tryptophan metabolism disordered SCFAs production are concurrent factors influenced by associated OS development. Modulating microbiota, particularly introducing SCFAs-producing could be promising strategy combating OS.

Язык: Английский

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Risk assessment and environmental influencing factors of urinary polycyclic aromatic hydrocarbons metabolites in pregnant women in Zunyi

Journal of Environmental Sciences, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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The Association Between Maternal Dietary Intake and the Risk of Heavy Metals in Human Breast Milk in Korea

Toxics, Год журнала: 2025, Номер 13(5), С. 381 - 381

Опубликована: Май 8, 2025

Heavy metals (HMs) persist in the environment and enter human body via various pathways. Once stored adipose tissue, they can be transferred to breast milk, posing risks infants. Moreover, maternal diet plays a key role influencing HM levels milk. The aim of this study was measure concentration HMs, including lead (Pb), cadmium (Cd), mercury (Hg), arsenic (As), milk Korean mothers, assess their potential health risks, identify dietary factors Survey data on maternal–infant pairs samples from 209 healthy lactating mothers were collected between January March 2023. Trained nurses manually expressed prevent external contamination, intake systematically assessed using 24 h recall method. concentrations Pb, Cd, Hg, As measured, risk assessment conducted estimated daily hazard quotient. A multiple linear regression model employed evaluate association HMs factors. Cd detected 99% samples, high detection rates observed for Hg (97%), (89%), Pb (79%). Arsenic largest contributor HM-contaminated Positive associations legume seaweed consumption, vegetable sugar intake, meat intake. This highlights that is closely linked elevated potentially pose These findings underscore importance adopting reduce exposure promote safer breastfeeding practices.

Язык: Английский

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First Evidence of the Associations of Exposure to Pyrethroid Insecticides with the Risk of Gestational Diabetes Mellitus

Environmental Science & Technology Letters, Год журнала: 2024, Номер 11(5), С. 418 - 425

Опубликована: Апрель 5, 2024

Pyrethroids, a class of extensively used insecticides, may pose health risks to humans. Whether pyrethroid exposure contributes the development gestational diabetes mellitus (GDM) in pregnant women remains unknown. The potential association urinary concentrations metabolites [3-phenoxybenzoic acid (3-PBA) and 4-fluoro-3-phenoxybenzoic acid] with risk GDM was assessed using nested case-control study 220 cases 440 controls from prospective cohort. mediation roles oxidative stress biomarkers [advanced glycation end products (AGEs) malondialdehyde (MDA)] associations were investigated. Urinary 3-PBA these significantly higher than those controls. positively associated GDM. adjusted odds increased by 32% each unit increment ln-transformed concentration 3-PBA. significant dose–response relationships serum AGEs (Ptrend = 0.03) MDA < 0.001) observed. However, there no correlations between or MDA, nor effect on We provide first evidence that early pyrethroids is an environmental factor for

Язык: Английский

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