Oceans,
Год журнала:
2024,
Номер
5(2), С. 181 - 195
Опубликована: Апрель 3, 2024
Tetrabromobisphenol
A
(TBBPA)
is
a
fire-retardant
containing
bromine,
produced
in
large
quantities
worldwide
and
extensively
used
several
industrial
products.
This
compound
was
identified
as
potential
contaminant
of
the
environment,
causing
toxicity
to
organisms.
However,
its
remains
poorly
understood
marine
bivalves.
The
first
objective
this
work
evaluate
impact
TBBPA
on
mussels
(Mytilus
galloprovincialis)
exposed
for
28
days
various
concentrations
(0,
1,
10,
100
µg·L−1),
by
assessing
stress
biomarkers’
responses
(Glutathione
S-transferase,
superoxide
dismutase,
catalase,
lipid
peroxidation,
total
antioxidant
capacity,
ubiquitin,
caspase-3
acetylcholinesterase).
results
showed
that
lower
(1
10
µg·L−1)
were
efficiently
detoxified,
suggested
GST
activities,
which
supported
other
biomarkers.
most
pronounced
effects
observed
animals
highest
concentration
(100
suggesting
oxidative
stress.
Additionally,
significant
strong
correlations
found
between
capacity
some
biomarkers
(superoxide
dismutase
peroxidation),
showing
processes
involved
fighting
are
working
avoid
cell
injury.
In
brief,
mussels’
defense
mechanisms
capable
dealing
with
exposure
tested.
Despite
this,
risk
consuming
shellfish
or
fishery
products
contaminated
should
be
cause
concern.
Environmental Science & Technology,
Год журнала:
2023,
Номер
58(1), С. 63 - 74
Опубликована: Дек. 19, 2023
The
detrimental
effects
of
bisphenol
(BP)
exposure
are
a
concern
for
vulnerable
species,
Indo-Pacific
humpback
dolphins
(Sousa
chinensis).
To
investigate
the
characteristics
BP
profiles
and
their
adverse
impact
on
dolphins,
we
assessed
concentrations
six
BPs,
including
A
(BPA),
S
(BPS),
F
(BPF),
AF
(BPAF),
B
(BPB),
P
(BPP)
in
blubber
(n
=
26)
kidney
12)
stranded
Pearl
River
Estuary,
China.
BPS
accounted
largest
proportion
total
bisphenols
(∑BPs)
(55%)
(69%).
concentration
∑BP
was
significantly
higher
than
that
liver.
EC50
values
five
BPA
alternatives
were
lower
those
dolphin
skin
fibroblasts
(ScSF)
human
(HSF).
ScSF
more
sensitive
to
BPS,
BPAF,
BPB,
BPP
HSF.
enrichment
pathway
found
be
associated
with
inflammation
immune
dysregulation,
while
demonstrated
preference
genotoxicity.
BPA,
BPP,
which
had
risk
quotients
(RQs)
>
1,
contribute
subhealth
chronic
disease
dolphins.
According
EC50-based
assessment,
poses
health
This
study
successfully
evaluated
risks
rare
endangered
cetacean
cell
lines
using
noninvasive
method.
More
vivo
field
observations
necessary
know
whether
likely
regrettable
substitutions.
Oceans,
Год журнала:
2024,
Номер
5(2), С. 181 - 195
Опубликована: Апрель 3, 2024
Tetrabromobisphenol
A
(TBBPA)
is
a
fire-retardant
containing
bromine,
produced
in
large
quantities
worldwide
and
extensively
used
several
industrial
products.
This
compound
was
identified
as
potential
contaminant
of
the
environment,
causing
toxicity
to
organisms.
However,
its
remains
poorly
understood
marine
bivalves.
The
first
objective
this
work
evaluate
impact
TBBPA
on
mussels
(Mytilus
galloprovincialis)
exposed
for
28
days
various
concentrations
(0,
1,
10,
100
µg·L−1),
by
assessing
stress
biomarkers’
responses
(Glutathione
S-transferase,
superoxide
dismutase,
catalase,
lipid
peroxidation,
total
antioxidant
capacity,
ubiquitin,
caspase-3
acetylcholinesterase).
results
showed
that
lower
(1
10
µg·L−1)
were
efficiently
detoxified,
suggested
GST
activities,
which
supported
other
biomarkers.
most
pronounced
effects
observed
animals
highest
concentration
(100
suggesting
oxidative
stress.
Additionally,
significant
strong
correlations
found
between
capacity
some
biomarkers
(superoxide
dismutase
peroxidation),
showing
processes
involved
fighting
are
working
avoid
cell
injury.
In
brief,
mussels’
defense
mechanisms
capable
dealing
with
exposure
tested.
Despite
this,
risk
consuming
shellfish
or
fishery
products
contaminated
should
be
cause
concern.
