Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches

Molecular Cancer, Год журнала: 2023, Номер 22(1)

Опубликована: Окт. 6, 2023

Abstract Skin cancer is a global threat to the healthcare system and estimated incline tremendously in next 20 years, if not diagnosed at an early stage. Even though it curable stage, novel drug identification, clinical success, resistance another major challenge. To bridge gap bring effective treatment, important understand etiology of skin carcinoma, mechanism cell proliferation, factors affecting growth, resistance. The current article focusses on understanding structural diversity cancers, treatments available till date including phytocompounds, chemotherapy, radiotherapy, photothermal therapy, surgery, combination molecular targets associated with growth metastasis, special emphasis nanotechnology-based approaches for downregulating deleterious disease. A detailed analysis respect types nanoparticles their scope overcoming multidrug as well trials has been discussed. Graphical

Язык: Английский

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Niosomes: Composition, Formulation Techniques, and Recent Progress as Delivery Systems in Cancer Therapy

Pharmaceutics, Год журнала: 2024, Номер 16(2), С. 223 - 223

Опубликована: Фев. 4, 2024

Niosomes are vesicular nanocarriers, biodegradable, relatively non-toxic, stable, and inexpensive, that provide an alternative for lipid-solid carriers (e.g., liposomes). may resolve issues related to the instability, fast degradation, bioavailability, insolubility of different drugs or natural compounds. can be very efficient potential systems specific delivery anticancer, antioxidant, anti-inflammatory, antimicrobial, antibacterial molecules. This review aims present overview their composition, most common formulation techniques, as well recent utilizations in cancer therapy.

Язык: Английский

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Carbon nanotube-mediated platinum-based drug delivery for the treatment of cancer: Advancements and future perspectives

European Polymer Journal, Год журнала: 2024, Номер 206, С. 112800 - 112800

Опубликована: Янв. 26, 2024

Язык: Английский

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Recent advances in nanotechnology

International Journal of Nanomaterials Nanotechnology and Nanomedicine, Год журнала: 2023, Номер 9(2), С. 015 - 023

Опубликована: Сен. 15, 2023

Introduction: Recent advances in nanotechnology have shown significant progress various fields. Nanotechnology involves the manipulation and control of matter at nanoscale, typically ranging from 1 to 100 nanometers. This field has potential revolutionize industries such as electronics, medicine, energy, materials science. led development smaller more efficient devices electronics. Nanoscale transistors memory chips increased computing power storage capacity. Additionally, nanomaterials like carbon nanotubes graphene promise creating flexible transparent Method materials: In opened new possibilities for targeted drug delivery imaging. Nanoparticles can be designed specifically target cancer cells, delivering drugs directly affected area while minimizing side effects. Nano-sensors also used early detection diseases monitoring patient health. Energy is another where made advancements. Nanomaterials quantum dots nanowires improved efficiency solar making them cost-effective sustainable. plays a role energy storage, with high-capacity batteries supercapacitors. Materials science benefited nanotechnology. Nanocomposites, which are nanoscale fillers, enhanced mechanical, thermal, electrical properties. These find applications aerospace, automotive, construction industries. Conclusion: Overall, recent paved way exciting Continued research this hold further breakthroughs advancements future.

Язык: Английский

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Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(16), С. 3807 - 3839

Опубликована: Янв. 1, 2024

This review article explores the innovative field of eco-friendly cyclodextrin-based coordination polymers and metal-organic frameworks (MOFs) for transdermal drug delivery in case skin cancer therapy. We critically examine significant advancements developing these nanocarriers, with a focus on their unique properties such as biocompatibility, targeted release, enhanced permeability. These attributes are instrumental addressing limitations inherent traditional treatments represent paradigm shift towards more effective patient-friendly therapeutic approaches. Furthermore, we discuss challenges faced optimizing synthesis process large-scale production while ensuring environmental sustainability. The also emphasizes immense potential clinical applications nanocarriers therapy, highlighting role facilitating targeted, controlled release which minimizes systemic side effects. Future could see being customized to individual patient profiles, potentially revolutionizing personalized medicine oncology. With further research trials, hold promise transforming landscape treatment. this study, aim provide comprehensive overview current state outline future directions advancing development application nanocarriers.

Язык: Английский

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Harnessing phytoconstituents in ethosomes: A new frontier in skin disorder management

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125273 - 125273

Опубликована: Янв. 1, 2025

Язык: Английский

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Bioadhesive Nanoparticles in Topical Drug Delivery: Advances, Applications, and Potential for Skin Disorder Treatments

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 229 - 229

Опубликована: Фев. 10, 2025

Skin disorders are the fourth most common cause of all diseases, which affect nearly one-third world’s population. Topical drug delivery can be effective in treating a range skin disorders, including microbial infections, cancer, dermatitis, burn injury, wounds, and psoriasis. Bioadhesive nanoparticles (BNPs) serve as an efficient topical system they dual purposes bioadhesives nanocarriers, mediate targeted delivery, prolong retention time, deepen penetration through layers. There is increasing demand for BNP-based applications medicine because their various advantages, biodegradability, flexibility, biocompatibility, enhanced adhesive strength. A number BNPs have already been developed evaluated potential systems. In addition, studies carried out to evaluate treatment atopic irritant contact psoriasis, severe injuries. This review article timely unique, it provides extensive unique summary recent advances wide-ranging disorders. Moreover, this also useful discussion on bioadhesion mechanism biopolymers that used prepare BNPs.

Язык: Английский

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CYP3A4 and CYP3A5: the crucial roles in clinical drug metabolism and the significant implications of genetic polymorphisms

PeerJ, Год журнала: 2024, Номер 12, С. e18636 - e18636

Опубликована: Дек. 5, 2024

CYP3A, a key member of the cytochrome P450 (CYP450) superfamily, is integral to drug metabolism, processing substantial portion medications. Their role in metabolism particularly prominent, as CYP3A4 and CYP3A5 metabolize approximately 30–50% known drugs. The genetic polymorphism CYP3A4/5 significant inter-individual variability enzymatic activity, which can result different pharmacokinetic profiles response same among individuals. These polymorphisms lead either increased toxicity or reduced therapeutic effects, requiring dosage adjustments based on profiles. Consequently, study activity gene variants great importance for formulation personalized treatment regimens. This article first reviews human body, including inhibitors inducers drug-drug interactions. In terms polymorphism, it discusses detection methods, kinetic characteristics, clinical guidelines CYP3A5. Finally, summarizes applications, therapy, management interactions, adjustment doses. review contributes understanding functions characteristics CYP3A4/5, allowing more effective outcomes through optimized therapy.

Язык: Английский

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Hybrid hydrogels based on agarose, halloysite nanotubes and polyvinyl alcohol: An excellent nanocarrier for controlled release of 5-fluorouracil

Hybrid Advances, Год журнала: 2024, Номер 5, С. 100139 - 100139

Опубликована: Янв. 1, 2024

Nanotechnology, rather than traditional medicinal procedures like chemotherapy, now helps to reduce adverse effects. There is a great demand for biocompatible nanocarrier with long half-life, high bioavailability, and capable of imaging cells targeting them selectively. A procedure known as water-in-oil-in-water (W/O/W) emulsification was employed produce hybrid nanohydrogels containing agarose, polyvinyl alcohol, halloysite nanotubes, 5-fluorouracil (AGA-PVA-HNT@5-Fu) which can be highly effective decreasing the particle size improving their uniformity. These hydrogels were produced specifically target administer 5-Fu anti-cancer drug treatment breast cancer. Following evaluation physicochemical characteristics, both substantial loading efficient trapping accomplished. The displayed zeta potential −38.4 mV indicative good stability due usage span 80. Based on release profile conducted in vitro, it observed that AGA-PVA-HNT@5-Fu released medication regulated way. By using MTT flow cytometry analysis, found could effectively eliminate tumor cells, while blank nanoparticles proved biocompatible. results indicate based utilized treating

Язык: Английский

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PLGA nanomedical consignation: A novel approach for the management of prostate cancer

International Journal of Pharmaceutics, Год журнала: 2024, Номер 652, С. 123808 - 123808

Опубликована: Янв. 14, 2024

Язык: Английский

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