International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138793 - 138793
Опубликована: Дек. 1, 2024
Язык: Английский
European Polymer Journal, Год журнала: 2024, Номер 209, С. 112924 - 112924
Опубликована: Март 11, 2024
Язык: Английский
Процитировано
4
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Янв. 29, 2025
Alzheimer’s disease (AD) is one of the most common diseases central nervous system in middle-aged and elderly population. It a neurodegenerative disorder, its main clinical symptoms include loss established memories, decline learning capacity, buildup β-amyloid peptides. The often accompanied by changes formation neurofibrillary tangles. However, number drugs available for treatment AD remains limited. Currently, existing medications are not effective completely curing or stopping progression. Due to their excellent biocompatibility biodegradability, polymers have been widely used as drug delivery carriers various fields including cancer therapy wound healing. use enables targeted prolonged release profiles. In recent years, researchers made significant progress utilizing such polyethylene glycol, poly (lactic-co-glycolic acid) (PLGA), chitosan (CS) deliver blood-brain barrier receptor ligands AD. Moreover, many with inherent therapeutic properties developed, already marketed GV-971 well experimental PLGA CS oligosaccharide. This review summarizes applications over past few years highlights current limitations help better understand advancements polymer development identify future research directions.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
European Polymer Journal, Год журнала: 2024, Номер 220, С. 113427 - 113427
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
3
Nano-Structures & Nano-Objects, Год журнала: 2024, Номер 40, С. 101378 - 101378
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
2
Regenerative Biomaterials, Год журнала: 2024, Номер 11
Опубликована: Янв. 1, 2024
Cartilage tissue engineering offers hope for tracheal cartilage defect repair. Establishing an anti-inflammatory microenvironment stands as a prerequisite successful restoration, especially in immunocompetent animals. Hence, scaffolds inducing response before chondrogenesis are crucial effectively addressing defects. Herein, we develop shell-core structured PLGA@ICA-GT@KGN nanofilm using poly(lactic-co-glycolic acid) (PLGA) and icariin (ICA, drug) the shell layer gelatin (GT) kartogenin (KGN, chondrogenic factor) core via coaxial electrospinning technology. The resultant exhibited characteristic fibrous structure demonstrated high biocompatibility. Notably, it showcased sustained release characteristics, releasing ICA within initial 0 to 15 days gradually KGN between 11 29 days. Subsequent vitro analysis revealed potent capabilities of released from layer, while induced differentiation bone marrow stem cells (BMSCs). Following this, synthesized nanofilms were loaded with BMSCs stacked by adhering 'sandwich model' form composite sandwich construct. This construct was then utilized repair circular defects rabbit model. sequential facilitated established initiating induction, leading effective restoration. study underscores significance temporally regulating anti-inflammation chondrogenesis. approach novel perspective defects, potentially revolutionizing their treatment methodologies.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138793 - 138793
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0