Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches

Molecular Cancer, Год журнала: 2023, Номер 22(1)

Опубликована: Окт. 6, 2023

Abstract Skin cancer is a global threat to the healthcare system and estimated incline tremendously in next 20 years, if not diagnosed at an early stage. Even though it curable stage, novel drug identification, clinical success, resistance another major challenge. To bridge gap bring effective treatment, important understand etiology of skin carcinoma, mechanism cell proliferation, factors affecting growth, resistance. The current article focusses on understanding structural diversity cancers, treatments available till date including phytocompounds, chemotherapy, radiotherapy, photothermal therapy, surgery, combination molecular targets associated with growth metastasis, special emphasis nanotechnology-based approaches for downregulating deleterious disease. A detailed analysis respect types nanoparticles their scope overcoming multidrug as well trials has been discussed. Graphical

Язык: Английский

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Cellular senescence in lung cancer: Molecular mechanisms and therapeutic interventions

Ageing Research Reviews, Год журнала: 2024, Номер 97, С. 102315 - 102315

Опубликована: Апрель 26, 2024

Lung cancer stands as the primary contributor to cancer-related fatalities worldwide, affecting both genders. Two types exist where non-small cell lung (NSCLC), accounts for 80–85% and SCLC 10-15% of cases. NSCLC subtypes include adenocarcinoma, squamous carcinoma, large carcinoma. Smoking, second-hand smoke, radon gas, asbestos, other pollutants, genetic predisposition, COPD are risk factors. On hand, stresses such DNA damage, telomere shortening, oncogene activation cause a prolonged cycle halt, known senescence. Despite its initial role tumor-suppressing mechanism that slows growth, excessive or improper control this process can age-related diseases, including cancer. Cellular senescence has two purposes in Researchers report tumor growth by constraining multiplication impaired cells. However, senescent cells also demonstrate pro-inflammatory senescence-associated secretory phenotype (SASP), which is widely reported promote This review will look at cellular cancer, describe diagnostic markers, ask about current treatments it, case studies clinical trials show how senescence-targeting therapies be used talk problems currently being faced, possible solutions same future.

Язык: Английский

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Recent progress in zein nanoparticles: A promising approach for advancing cancer therapy

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 97, С. 105770 - 105770

Опубликована: Май 11, 2024

Язык: Английский

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Liposomal drug delivery strategies to eradicate bacterial biofilms: Challenges, recent advances, and future perspectives

International Journal of Pharmaceutics, Год журнала: 2024, Номер 655, С. 124046 - 124046

Опубликована: Март 29, 2024

Typical antibiotic treatments are often ineffectual against biofilm-related infections since bacteria residing within biofilms have developed various mechanisms to resist antibiotics. To overcome these limitations, antimicrobial-loaded liposomal nanoparticles a promising anti-biofilm strategy as they demonstrated improved delivery and eradication of in biofilms. Antibiotic-loaded revealed remarkably higher antibacterial activities than free drugs experimental settings. Moreover, can be used efficaciously for the combinational antibiotics other antimicrobial compounds/peptide which facilitate, instance, significant breakdown biofilm matrix, increased bacterial elimination from depletion metabolic activity pathogens. Drug-loaded liposomes mitigated recurrent considered tool address challenges associated resistance. Furthermore, it has been that surface charge polyethylene glycol modification notable impact on their activity. Future investigations should tackle persistent hurdles with development safe effective clinical application investigate novel treatments, including CRISPR-Cas gene editing, natural compounds, phages, nano-mediated approaches. Herein, we emphasize significance inhibition biofilms, challenges, recent advances, future perspectives.

Язык: Английский

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Folate-engineered chitosan nanoparticles: next-generation anticancer nanocarriers

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Окт. 31, 2024

Chitosan nanoparticles (NPs) are well-recognized as promising vehicles for delivering anticancer drugs due to their distinctive characteristics. They have the potential enclose hydrophobic molecules, thereby enhancing solubilities, permeabilities, and bioavailabilities; without use of surfactant, i.e., through surfactant-free solubilization. This allows higher drug concentrations at tumor sites, prevents excessive toxicity imparted by surfactants, could circumvent resistance. Moreover, biomedical engineers formulation scientists can also fabricate chitosan NPs slowly release agents. keeps site longer, makes therapy more effective, lowers frequency dosing. Notably, some types cancer cells (fallopian tube, epithelial tumors ovary, primary peritoneum; lung, kidney, ependymal brain, uterus, breast, colon, malignant pleural mesothelioma) overexpression folate receptors (FRs) on outer surface, which lets folate-drug conjugate–incorporated target kill them effectively. Strikingly, there is evidence suggesting that excessively produced FR&αgr (isoforms FR) stays consistent throughout treatment in ovarian endometrial cancer, indicating resistance conventional treatment; this regard, folate-anchored overcome it improve therapeutic outcomes. Interestingly, overly expressed FRs present only certain types, a biomarker predicting effectiveness FR-targeted therapy. On other hand, folate-modified enhance oral absorption medicines, especially drugs, pave way effective long-term low-dose metronomic scheduling poorly soluble permeable drugs. In review, we talked briefly about techniques used create, characterize, tailor chitosan-based NPs; delved deeper into applications folate-engineered treating various types. Schematic illustration ligand-drug incorporated its advantage cancer. Figure created with BioRender.Com.

Язык: Английский

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Exploring How Adipose Tissue, Obesity, and Gender Influence the Immune Response to Vaccines: A Comprehensive Narrative Review

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 862 - 862

Опубликована: Янв. 20, 2025

Vaccines represent an essential tool for the prevention of infectious diseases. Upon administration, a complex interaction occurs between vaccine formulation and recipient’s immune system, ultimately resulting in protection against disease. Significant variability exists individual population responses to vaccination, these differences remain focus ongoing research. Notably, well-documented factors, such as age, gender, genetic predisposition, influence responses. In contrast, effects overweight obesity have not been thoroughly investigated. The evidence indicates that high body mass index (BMI) constitutes significant risk factor infections general, with adipose tissue playing crucial role modulating response. Furthermore, suboptimal levels seroconversion observed among individuals obesity. This review provides plausible examination immunity conferred by various vaccines status, offering comprehensive analysis mechanisms enhance vaccination efficiency.

Язык: Английский

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Effectiveness of phytoconstituents and potential of phyto-nanomedicines combination to treat osteoarthritis

European Polymer Journal, Год журнала: 2024, Номер 215, С. 113243 - 113243

Опубликована: Июль 1, 2024

Osteoarthritis (OA) is a well-known degenerative joint disease recognized by the deterioration of cartilage in joints, leading to pain and reduced mobility. Traditional treatments for OA include management, physical therapy, severe cases, replacement surgery. In recent years, there has been growing interest exploring potential phytoconstituents nanomedicines combined treating OA. Furthermore, with increasing amount study this field, now opportune time widespread use plant-derived medications as complementary alternative medical therapies be acknowledged used more efficient treatment human ailments like Combining nanomedicine technology (phyto-nanomedicine) can potentially enhance their effectiveness The phyto-nanomedicines many advantages, including enhanced permeability, increased bioavailability, sustained/controlled drug release at site, decreased adverse effects, possible combination treatment. It's important note that while promising preclinical some clinical evidence regarding phyto-nanomedicine treatment, further research needed establish safety efficacy conclusively. review, treat combining phytomedicines nanoparticulate delivery former therapeutic discussed detail. we have also described briefly on application organ-on-chip and/or on-chip models accelerate identification novel evaluate potency

Язык: Английский

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Understanding the journey of biopolymeric nanoformulations for oral drug delivery: Conventional to advanced treatment approaches

European Polymer Journal, Год журнала: 2024, Номер 218, С. 113338 - 113338

Опубликована: Июль 26, 2024

Язык: Английский

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Antibiotic loaded inhalable liposomal nanoparticles against lower respiratory tract infections: Challenges, recent advances, and future perspectives

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 94, С. 105517 - 105517

Опубликована: Фев. 28, 2024

Lower respiratory tract infections (LRTIs) are inherited disorders which often causes chronic for patients repeatedly receive oral antibiotics, particularly during periods of worsened lung symptoms. However, the existing treatment modalities unable to completely clear responsible pathogens, contributes emergence antimicrobial resistance (AMR). To circumvent these issues, direct delivery antibiotics infected cells by inhalation is emerging as a preferred strategy. More importantly, antibiotic-loaded inhalable liposomal nanoparticles (ALILNPs) an attractive option efficient management LRTIs such cystic fibrosis (CF), obstructive pulmonary disease (COPD), and bronchiectasis. ALILNPs have demonstrated significantly higher antibacterial efficacy in both preclinical clinical settings. Furthermore, several studies reported that inhaled show sustained enhancements function amelioration forced expiratory volume 1 s (FEV1) depletion P. aeruginosa density. Liposome considered safe administering range improve remedial effectiveness incorporated agents diminish drug toxicity. Toxicity aspects liposomes are, however, still not abundantly reported. Thus, there exists compelling requirement development vitro or vivo models gain insights into safety within system. Although, impact on macrophages biofilms arising from well established, full potential formulations yet be realised. Herein, we discuss challenges, recent advances, future perspectives various pathogens associated with LRTIs.

Язык: Английский

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Classes/types of polymers used in oral delivery (natural, semisynthetic, synthetic), their chemical structure and general functionalities

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 263 - 333

Опубликована: Окт. 4, 2024

Язык: Английский

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